Archive

FibriLysins disrupt Staphylococcus aureus biofilms and abscess communities.

If engineered staphylokinase-endolysin enzymes clear fibrin-encased MRSA abscesses in vivo, this offers a non-antibiotic adjunct for the recurrent skin and soft-tissue infections you already struggle to cure.

General Medicine · Nature microbiology · 5d

Bispecific dual T cell agonist invikafusp alfa in solid tumors: the phase 1/2 START-001 trial.

A first-in-class T cell agonist that targets Vβ6/Vβ10 subsets rather than checkpoint pathways offers a new mechanism for patients whose tumours have already progressed on immunotherapy.

Oncology · Nature Medicine · 5d

Interim Analysis of a Phase 3 Trial of Povetacicept in IgA Nephropathy.

Dual BAFF/APRIL blockade targets the B-cell drivers of IgA nephropathy; if proteinuria falls durably, it becomes a disease-modifying option beyond renin-angiotensin blockade.

General Medicine · NEJM · 5d

Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic cancer: the randomized phase 2 AMPLIFY-7P trial.

Primary DFS endpoint not met: median 23.8 versus 21.2 months (HR 0.85, P = 0.5329). Grade ≥3 adverse events 10.4% versus 14.6%; serious AEs 6.3% versus 8.3%.

Oncology · Nature Medicine · 5d

Trial of Endovascular Therapy for Mild Stroke with Large-Vessel Occlusion.

Excellent 90-day outcome (mRS 0-1) in 69.4% with endovascular therapy versus 50.0% with medical management alone (odds ratio 2.32; 95% CI 1.41 to 3.81; P<0.001). Symptomatic intracranial haemorrhage occurred in 3 patients per group.

Neurology · NEJM · 5d

Determinants of response to CAR T cell therapy in a multicenter, multi-trial cohort analysis of patients with lymphoma.

High versus low naive-like (CCR7+CD45RA+) T cells in the product gave prolonged PFS: hazard ratio 0.46 (95% CI 0.31-0.68), with no impact on safety.

Oncology · Nature Medicine · 5d

Functional Versus Mechanical Alignment in Robotic-Assisted Primary Total Knee Arthroplasty: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

If functional alignment's PROM advantage over mechanical alignment holds across RCTs, it supports adopting robotic workflows that individualize component positioning rather than targeting a fixed mechanical axis.

Orthopaedics · Cureus · 5d

Saved by Bell's Palsy: Recurrent Facial Weakness in a Patient With a Cerebellopontine Angle Mass

Recurrent facial palsy with headache or vertigo warrants imaging — a cerebellopontine angle mass can mimic Bell's, and steroids alone would delay its diagnosis.

Neurology · Cureus · 5d

Routes to Diagnosis and Stage at Diagnosis of Colorectal Cancer in Patients Aged ≥ 50 Years: A Multicentre Retrospective Cohort Study From North Wales, UK

Which referral route a patient takes still predicts their CRC stage, so how you triage rectal bleeding and FIT results directly shapes whether they present operable.

Oncology · Cureus · 5d

Cancer and Advanced Adenoma Detection After Acute Diverticulitis: A Retrospective Cohort Study

Informs whether to still refer diverticulitis patients for follow-up colonoscopy, especially after complicated episodes, now that high-resolution CT is widely used.

Gastroenterology · Cureus · 5d

Association of the 2HELPS2B Score With Impaired Recovery of Consciousness and In-Hospital Mortality in Critically Ill Patients: A Multicenter Retrospective Study

A routine EEG risk score may flag sedated ICU patients unlikely to regain consciousness, helping you time neuroprognostication and family discussions earlier.

Neurology · Cureus · 5d

MRI Accuracy for Detecting Deep Myometrial Invasion in Low-Grade Endometrial Cancer: Insights From a Seven-Year UK Experience

MRI staging of myometrial depth guides whether low-grade endometrial cancer needs lymphadenectomy or radical surgery, so its real-world accuracy directly shapes your operative plan.

Obstetrics & Gynaecology · Cureus · 5d

Prognostic Value of High-Sensitivity C-reactive Protein, Interleukin-6, and Lipoprotein(a) in Acute Ischemic Stroke and Recurrent Cerebrovascular Events: A Systematic Review and Meta-Analysis

Elevated biomarkers were associated with poor functional outcome (pooled OR 2.28, 95% CI 1.77-2.80), with substantial heterogeneity (I² = 90.38%). hs-CRP was most consistent (OR 2.29, 95% CI 1.96-2.61); IL-6 did not reach significance (OR 2.30, 95% CI 0.21-4.40).

Neurology · Cureus · 5d

FDA Launches New Program to Advance Neuroscience Medical Product Development

A faster FDA pathway for neuro drugs could shorten the wait before your patients with Parkinson's, epilepsy or Alzheimer's get new options.

Neurology · FDA — Press Announcements · 5d

Extragenital Lichen Sclerosus and Granulomatous Dermatitis in a Patient Treated With Nivolumab and Ipilimumab for Malignant Melanoma: A Case Report

IrAEs can present sequentially over months on dual checkpoint blockade; biopsy unusual rashes rather than assuming a single drug reaction, since management may differ.

Oncology · Cureus · 5d

Dexmedetomidine as an Adjuvant to Local Anesthetics for Postoperative Analgesia in Breast Cancer Surgery

Most studies report longer analgesia and lower postoperative analgesic consumption with dexmedetomidine added to local anaesthetic; doses of 0.5-1 μg/kg were most commonly investigated. Bradycardia and hypotension remain relevant safety concerns

Anaesthesiology · Cureus · 5d

Extending the Lower Limits of Body Weight for Bi-directional Glenn Shunt in Developing Countries: Is it Feasible?

Suggests a 2.7 kg infant can undergo BDG shunting in resource-limited settings, supporting earlier palliation rather than waiting for weight gain that may never come.

Cardiology · Cureus · 5d

Intradetrusor Botulinum Toxin A at Doses of 100 and 200 Units for Urinary Incontinence in Women: A Single-Center Retrospective Study From Saudi Arabia

Both 100 and 200 unit intradetrusor BoNT-A doses improved refractory urgency incontinence in women here; dose choice can follow response and cost rather than habit.

Urology · Cureus · 5d

Diagnostic Tools Used for Tuberculous Pleural Effusion and Their Association With Treatment Outcomes

In paucibacillary TPE, your choice of pleural fluid biomarker, molecular assay or biopsy — not just availability — tracks with treatment outcome, so escalate diagnostics early.

General Medicine · Cureus · 5d

Pathogens and the Bladder: Decoding the Infective Footprints in Bladder Carcinoma

Chronic urinary infection and repeated catheterisation may add to bladder cancer risk, so treat recurrent UTIs and catheter use as potentially carcinogenic exposures worth documenting and following up.

Urology · Cureus · 5d

Navigating Services for Adults With Intellectual and Developmental Disabilities in Florida: A Five-Question Guide for Clinicians

Gives you five concrete questions to route adults with IDD to waiver-funded mobility equipment, sedation dentistry and behaviour support you were never trained to find.

Psychiatry · Cureus · 5d

Sentara Health deploys new AI case management tool co-developed with Regard

An AI tool claiming 90,000 staff hours saved in acute care signals where hospital case management is heading — worth watching if your ward's discharge and follow-up load is the bottleneck.

General Medicine · Fierce Healthcare · 5d

STAT+: FDA has finalized its guidance on apps related to drugs

If you prescribe apps or device-linked software with a drug, the FDA's final rule now fixes who regulates it and what claims you can rely on.

General Medicine · STAT News — Health Tech · 5d

Declining Leprosy-Related Hospitalization Rates and Increasing In-Hospital Case Fatality in Brazil: A Nationwide Ecological Time-Series Study, 2008-2023

Fewer leprosy admissions but higher in-hospital death signals delayed presentation; watch for late-stage disease in your own referrals.

General Medicine · Cureus · 5d

TN conducting India's first dengue vaccine pilot study, says Minister Arunraj

If the Brazilian-schedule vaccine proves feasible here, dengue hospitalisations in your paediatric and adult practice could fall; watch for pilot safety data before advising families.

General Medicine · ETHealthworld · 5d

Effectiveness of Epidural Steroid Injections in Lumbar Radiculopathy: A Systematic Review of Randomized Controlled Trials

Before referring for epidural steroids, know the RCT evidence supports only short-term relief in true radicular pain, not lasting benefit in radiculitis.

Anaesthesiology · Cureus · 5d

STAT+: Telehealth leapfrogs FDA approval with off-label GLP-1 prescriptions for addiction

Patients will ask you for GLP-1s for alcohol or opioid use disorder; there is no approval or safety data, and telehealth is already prescribing it without your oversight.

Psychiatry · STAT News — Health Tech · 5d

Clear Skin, Vanishing Brows: Trichoscopy-Confirmed Eyebrow Alopecia Areata Associated With Secukinumab

PASI fell from 36.9 to 15.6 at week 8 and 0 at week 16. Bilateral eyebrow thinning appeared at week 16; trichoscopy showed black dots, circle hairs and short vellus hairs. Regrowth complete three months after stopping.

Oncology · Cureus · 5d

Clinical Evaluation of the Efficacy and Safety of Ondansetron in Pediatric Acute Gastroenteritis: A Systematic Review of Clinical Profiles, Healthcare Utilization, and Hospital Outcomes

RCTs: fewer vomiting episodes at 48 hours (adjusted rate ratio 0.76; 95% CI 0.67-0.87); less moderate-to-severe disease (5.1% vs 12.5%; adjusted OR 0.50); IV fluids 14% vs 31% (RR 0.46). Adverse events similar (7.0% vs 7.1%).

Paediatrics · Cureus · 5d

Stricter diagnostic lab rules for CGHS fuel double standards charge

If you refer CGHS patients, tighter lab categorisation may change which tests are covered where, so check empanelment before sending samples.

General Medicine · ETHealthworld · 5d

Case Mix and Protocol Constraints in Diagnostic Language Model Conversations: A Secondary Analysis of Released MedR-Bench Outputs

Benchmark scores for diagnostic AI partly reflect the test protocol and simulator, not clinical reasoning — so don't read a leaderboard as readiness for your ward.

General Medicine · Cureus · 5d

Contralateral and Ipsilateral Second Injuries of the Anterior Cruciate Ligament After Primary Reconstruction in Sport-Active Patients: A Retrospective Cohort Study

Twelve patients (21.4%; 95% CI 11.6-34.4) had a second ACL injury: seven contralateral ruptures (12.5%; 95% CI 5.2-24.1) versus five ipsilateral re-ruptures (8.9%; 95% CI 3.0-19.6), p = 0.77.

Orthopaedics · Cureus · 5d

Cognitive Task Substitution, Cognitive Offloading, and Behavioral Dependency on Artificial Intelligence-Assisted Technologies: A Scoping Review

ChatGPT users scored 57.5% on 45-day retention versus 68.5% for traditional learners (p = 0.002); 89% of educators reported perceived skill atrophy; AI use and human interaction correlated negatively (r = -0.443)

Medicine · Cureus · 6d

Researchers find a possible trigger of some preterm births

If antiphospholipid-type antibodies precede preterm delivery, early antibody screening in pregnancy could flag women for closer surveillance and possible prophylaxis.

Obstetrics & Gynaecology · ETHealthworld · 6d

FSSAI issues notices to Nestle, Zydus over 'misleading' claims

When parents ask whether HMO-fortified formula boosts immunity, the regulator's stance is that such claims overstate benefit in a specific physiological condition.

Paediatrics · ETHealthworld · 6d

CureBay Bags ₹100 Cr To Scale Rural Clinics Network, Enhance AI Screening Offerings

If you refer patients in underserved districts, this funds more rural clinics with AI-assisted screening — worth knowing where your patients can get checked closer to home.

General Medicine · Inc42 · 6d

Sibeprenlimab in IgA Nephropathy - Final Phase 3 Trial Analysis.

Final phase 3 data on APRIL inhibition give nephrologists a clearer picture of proteinuria and eGFR benefit before deciding where sibeprenlimab fits alongside standard IgA nephropathy care.

General Medicine · NEJM · 6d

Rituximab vs Azathioprine for Eosinophilic Granulomatosis With Polyangiitis Maintenance Therapy: A Randomized Clinical Trial.

Direct head-to-head data on which maintenance agent keeps EGPA patients in remission longer, where guidelines currently offer only weak recommendations.

General Medicine · JAMA · 6d

Atacicept in IgA Nephropathy - Phase 3 Trial Final Efficacy Analysis.

Final ORIGIN 3 results confirm atacicept's proteinuria reduction in biopsy-proven IgA nephropathy, giving nephrology a targeted option beyond supportive care for patients at risk of progression.

General Medicine · NEJM · 6d

BCG at 100: The Paradox of an Indispensable Vaccine.

Reinforces that BCG at birth protects infants from disseminated TB but not adult pulmonary disease, so adolescent and adult TB control still depends on case-finding and treatment.

General Medicine · Indian pediatrics · 6d