Archive

SC flags attacks on doctors in Maharashtra

Violence against doctors affects emergency care delivery and staff safety; any court signal on stricter protection may influence hospital security and reporting practices.

Medicine · ETHealthworld · 4d

Boston Scientific recalls spinal cord implant in wake of more than 1k serious injuries

Check patients with this implant for fracture risk; report adverse events promptly if you use this device.

Medicine · Fierce Biotech · 4d

Fundly.ai Raises $4 Mn To Scale Pharma Payments, Commerce Infra

Speeds medicine procurement and payment for clinics; reduces cash-flow delays in pharma supply.

Medicine · Inc42 · 4d

N-terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) Versus Artificial Intelligence-Enabled Electrocardiography for the Diagnosis of Acute Heart Failure in Emergency Departments: A Systematic Review

AI-ECG AUC 0.88-0.94, outperformed NT-proBNP in direct comparisons (0.89 vs 0.80; 0.91-0.92 vs 0.75). NT-proBNP sensitivity 96%-99%, specificity 54%-56% at 300 pg/mL.

Medicine · Cureus · 4d

Sentinel Lymph Node Positivity by Tumour Grade in Older Women With Breast Cancer: A Cross-Verified Retrospective Cohort Study

SLNB positive in 3/39 (7.7%; 95% CI 2.7-20.3%). Grade 2: 19.8% (95% CI 13.9-27.5%), Grade 3: 13.7% (95% CI 6.8-25.7%). No axillary recurrences.

Medicine · Cureus · 4d

AI in healthcare: Remote monitoring, ICU optimisation to be next growth frontiers

Expect AI tools to flag deteriorating patients earlier, potentially reducing ICU transfers and bedside workload.

Medicine · ETHealthworld · 4d

Bruton Tyrosine Kinase Inhibitor-Based Therapy Versus Rituximab-Containing Regimens for Chronic Lymphocytic Leukemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

BTK inhibitor-based therapy significantly prolonged PFS in eight trials (pooled HR, 0.42; 95% CI: 0.24-0.73; P=0.002; I²=93%). ORR was nonsignificant: 440 of 543 (81.0%) versus 350 of 491 (71.3%) (RR: 1.18; 95% CI: 0.98-1.42; P=0.08; I²=86%). OS also remained nonsignificant (HR: 0.67; 95% CI: 0.40-1.11; P=0.12; I²=48%).

Medicine · Cureus · 4d

B2B pharma distribution startup Fundly.ai raises $4 Mn led by Accel, Multiply

Fundly.ai raised $4 million led by Accel and Multiply Ventures, with around $0.9 million in venture debt. The company had earlier raised $3 million seed funding in 2023.

Medicine · Entrackr · 4d

Spiked Helmet Sign Associated With Acute Gastric Distension and Hemodynamic Instability: A Case Report

Sinus tachycardia at 135 bpm with spike-helmet morphology in lead II; after decompression, heart rate 83 bpm and morphology disappeared

Medicine · Cureus · 4d

Novartis’ centerpiece of $12B Avidity buyout flunks ‘crucial’ phase 3 test

Del-desiran missed its phase 3 primary endpoint, so it should not be assumed to improve outcomes for patients with Duchenne muscular dystrophy.

Medicine · Fierce Biotech · 4d

Questions Ophthalmology Trainees Ask About Ocular Syphilis: A Question-Driven Narrative Review

The review consolidated 26 questions into 15 across seven domains. It concluded ocular syphilis is best managed with a neurosyphilis treatment regimen, diagnosed with combined treponemal and nontreponemal tests, and monitored with serial nontreponemal titers.

Medicine · Cureus · 4d

Interventions to Improve Outpatient Follow-up for Hospitalized Patients With Alcohol Use Disorder : A Systematic Review.

Eight interventions (38%) reported improved linkage to outpatient follow-up. Across RCTs, effect sizes ranged from an 8% absolute decrease to a 30% absolute increase in outpatient follow-up.

Medicine · Annals · 4d

Association Between Blood Hemoglobin Concentration and Mortality by Age and Sex : A Prospective Cohort Study.

All-cause mortality was U-shaped. Compared with the reference group, 10-year SCI was 4.5% versus 12.5% when hemoglobin was more than 2 g/dL below threshold (ARD +8.1 percentage points; 95% CI 6.7 to 9.4; HR 2.87, CI 2.54 to 3.25).

Medicine · Annals · 4d

Tuberculosis.

Prompt diagnosis, isolation, and treatment improve patient outcomes and reduce transmission. Treatment requires multiple antibiotics for 4 to 9 months, guided by drug sensitivity testing.

Medicine · Annals · 4d

Tozorakimab to Prevent COPD Exacerbations.

In former smokers, annualized moderate or severe exacerbations were 1.34 vs 1.90 in OBERON (rate ratio, 0.71; 95% CI, 0.57 to 0.88; P = 0.002) and 1.37 vs 2.07 in TITANIA (rate ratio, 0.66; 95% CI, 0.55 to 0.80; P<0.001). In the overall population, rates were 1.41 vs 2.00 and 1.44 vs 2.03, respectively.

Medicine · NEJM · 4d

Wildfire smoke and health: current evidence, mechanisms, and future challenges.

No primary outcome or effect estimate reported. Authors state key gaps persist: long-term health effects, interactions with pre-existing conditions, and health disparities.

General Medicine · Lancet · 4d

Effect of Delayed Presentation on the Prognosis of Snakebite Victims at a Tertiary Care Hospital: The Golden Hour Matters

Mortality was 75% (3/4) in the 18-24-hour group versus 7.1% (1/14) in the zero-to-six-hour group. Recovery was highest in the zero-to-six-hour group at 71.4%.

General Medicine · Cureus · 5d

Prenatal Use of Sirolimus in Fetal Therapy: Current Evidence, Clinical Applications, and Future Directions

Case reports describe regression of symptomatic cardiac rhabdomyomas and improvement in outflow obstruction, arrhythmia, hydrops, or impending fetal compromise. No controlled data.

Obstetrics & Gynaecology · Cureus · 5d

Perioperative Systemic Analgesia in Patients With Inflammatory Skin Disease: A Matched Cohort Study

30-day opioid use lower in inflammatory cohort: 3.2% vs 7.0% (RD -3.8 percentage points, 95% CI -4.2 to -3.4; RR 0.46, 95% CI 0.42-0.50). Pain similar at 30 days, higher later.

Anaesthesiology · Cureus · 5d

Adverse and Positive Childhood Experiences and Suicidal Ideation in US Children and Adolescents: A Systematic Review and Meta-Analysis

Highest ACE category vs none: pooled relative estimate 7.19 (95% CI 5.66-9.14). Each additional ACE: odds ratio 1.60 (95% CI 1.52-1.69).

Psychiatry · Cureus · 5d

BrainChild Bio masterminds $116M series A for CAR-T's pivotal push in pediatric brain cancer

This could accelerate CAR-T development for pediatric brain tumors, a setting where current options are limited and trial access may expand for children with refractory disease.

Medicine · Fierce Biotech · 5d

Deep Learning Algorithms for the Diagnosis and Staging of Retinopathy of Prematurity: A Systematic Review and Meta-Analysis

Pooled sensitivity 95% (95% CI 91.5%-97.1%), specificity 97.4% (95% CI 95.3%-98.6%) for ROP identification; heterogeneity I²=0.75.

Medicine · Cureus · 5d

Yield and Predictors of Histologically Confirmed Colorectal Polyps in Adults Younger Than 45 Years Undergoing Non-screening Colonoscopy: A Retrospective Cohort Study

Polyps in 217/727 (29.8%; 95% CI, 26.6%-33.3%); neoplastic lesions in 139/727 (19.1%); advanced neoplasia in 33/727 (4.5%), including 4 invasive cancers. Age 40-43 odds ratio 3.84 (95% CI, 2.31-6.38).

Gastroenterology · Cureus · 5d

Deepinder Goyal’s Temple Takes First Step Towards Validating Its Wearable

If validated, this wearable could offer non-invasive brain flow monitoring in clinics, aiding early detection of neurological conditions.

Neurology · Inc42 · 5d

Imaging Pulmonary Embolism in the Era of Subsegmental Clots: What the Internist Needs to Know About Overdiagnosis, Anticoagulation, and Follow-Up

Short-term recurrence rates in SSPE are low and do not differ significantly from proximal PE. No randomized controlled trial data guide anticoagulation; selected low-risk patients may be safely observed.

General Medicine · Cureus · 5d

Novo’s blockbuster hopes for CKD program dwindle after more phase 3 trials scrapped

If you manage CKD patients, this anti-inflammatory agent's failure removes a potential option to slow progression; reconsider trial enrollment.

Medicine · Fierce Biotech · 5d

When an Extra X Means Extra Risk: Venous Thromboembolism in Klinefelter Syndrome

Massive bilateral pulmonary embolism with concurrent DVT occurred despite normal hematocrit (48.8% at admission, normal over 13 months), negative thrombophilia panel, implicating KS-intrinsic hypercoagulability.

General Medicine · Cureus · 5d

Acupuncture-Induced Pneumothorax Following Thoracic Acupuncture in a Patient With Ehlers-Danlos Syndrome: A Case Report

Left apical pneumothorax (2.8 cm) developed; aspiration removed 450 mL air, but repeat imaging showed minimal reduction; resolved spontaneously within 24 hours.

General Medicine · Cureus · 5d

Ranolazine in Chronic Stable Angina: A Systematic Review and Meta-Analysis

Exercise duration increased by 33.1 seconds (95% CI 27.3-38.9). MI risk reduced (RR 0.91; 95% CI 0.84-0.98), CABG (RR 0.55; 95% CI 0.35-0.86), any revascularization (RR 0.77; 95% CI 0.64-0.91). Adverse events more frequent (RR 1.45; 95% CI 1.27-1.66).

Cardiology · Cureus · 5d

Global lung cancer screening lessons offer roadmap for India: AIIMS expert

Prioritise high-risk groups and integrate screening with existing systems to make lung cancer detection feasible in India.

Oncology · ETHealthworld · 5d

Real-Time Intelligent Coaching Versus Human Expert Instruction in Surgical Skills Training: A Systematic Review and Meta-Analysis

No significant difference in technical performance (ICEMS and OSATS scores). ICEMS analysis had very high heterogeneity (I²=99%). Coaching reduced overall cognitive load; positive deactivating emotions modestly higher.

General Surgery · Cureus · 5d

Jada System Versus Bakri Balloon for Postpartum Hemorrhage: A Retrospective Cohort Study

No statistically significant differences in blood loss, transfusion, escalation to surgery, or ICU admission between devices.

Obstetrics & Gynaecology · Cureus · 5d

Guardant wins FDA nod for diagnostic guiding use of AstraZeneca’s Etcamah

This lets you identify patients eligible for Etcamah using Guardant’s companion test, so treatment selection can be aligned with the approved biomarker strategy.

Medicine · Fierce Biotech · 5d

IIT Madras patents polymer tech that disintegrates bacteria on surfaces without harming human cells

Offers a non-antibiotic surface coating to curb hospital-acquired infections and superbug spread, potentially reducing reliance on conventional antimicrobials.

General Medicine · ETHealthworld · 5d

PIL challenges Centre’s HPV vaccination drive, seeks Supreme Court intervention over consent, safety and accountability

School-based HPV vaccination may pause; verify consent protocols and legal status before counselling parents or administering doses.

Paediatrics · ETHealthworld · 5d

Use of the bacterial lysate OM-85 for the primary prevention of wheezing lower respiratory illness in preschool children: a randomised, placebo-controlled trial.

No significant difference in time to first wheezing lower respiratory tract illness: 71 (21%) of 342 with OM-85 versus 61 (18%) of 339 with placebo; hazard ratio 1·16 [95% CI 0·82-1·64], p value 0·35.

Medicine · Lancet · 5d

Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody-autoantigen pair in atherosclerosis.

Antibody A6 binds histone H2B with high affinity; vaccination with H2B and adoptive transfer of A6 accelerate atherosclerosis. Anti-H2B titers correlate with aortic calcification in humans.

Medicine · Nature cardiovascular research · 6d

Spatially guided in vivo single-cell functional genomics of postnatal heart.

Identified 21 previously uncharacterized regulators of cardiomyocyte maturation, including genes essential for sarcomere assembly, metabolic reprogramming and electrophysiological transitions.

Medicine · Nature cardiovascular research · 6d

AbbVie-backed ADARx plans IPO to bankroll array of clinical-stage siRNA therapies

IPO funds will advance siRNA drugs targeting multiple diseases; watch for efficacy data that could expand your therapeutic options.

Medicine · Fierce Biotech · 6d

FSSAI to tighten scrutiny, weighs central ban on non-dairy paneer

A central ban would curb adulterated analogue paneer in your patients' diets, reducing risks from undeclared fats and additives.

General Medicine · ETHealthworld · 6d