Archive

Efficacy and safety of mitapivat in adults with transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE-T): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

Transfusion reduction response occurred in 52 (30%) of 171 on mitapivat versus 11 (13%) of 87 on placebo; adjusted difference 18 percentage points (95% CI 8-27; p=0·0003).

General Medicine · Lancet · 7h

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Genome Editing in Inherited Cardiovascular Diseases: Therapeutic Advances, Emerging Editing Platforms, and Translational Challenges

No trial results are reported. Preclinical work corrected MYBPC3 and MYH7 in HCM, targeted TTN, RBM20 and LMNA in DCM, restored ion channel function, and modulated PCSK9, LDLR and ANGPTL3.

Cardiology · Cureus · 11h

Systematic Review and Meta-Analysis on Central and/or Peripheral Nervous System Demyelination in Patients Treated With Tumor Necrosis Factor Alpha (TNF-α) Inhibitors

Pooled random-effects estimates: RR 1.46 (95% CI 1.09-1.95) for CNS demyelination and RR 2.00 (95% CI 1.19-3.38) for PNS demyelination.

Neurology · Cureus · 13h

Cardiac Metastasis From Lung Cancer: A Hidden Cardioembolic Source of Acute Ischemic Stroke

Brain MRI showed multiple acute ischemic infarcts in the left middle cerebral artery territory; cardiac imaging found a left ventricular mass suggestive of metastasis. She died one year later.

Neurology · Cureus · 13h

Benchmarking Drug Library Compliance and Alert Rates in Smart Infusion Pumps: A Multicenter Retrospective Study

Overall DL compliance was 95.9%, mean alert rate 33.3% (±12.20), override rate 96.4%, and one good catch per 34.5 DERS infusions. No significant differences between compliance groups.

Anaesthesiology · Cureus · 15h

Jugular Venous Compression via Soft Cervical Collar in Shunt-Refractory Low-Pressure Hydrocephalus: A Report of Two Cases

Third ventricular width decreased from 13 to 8 mm in case 1 and 13 to 4 mm in case 2; ventriculomegaly recurred on collar cessation and resolved on reapplication in case 1

Neurology · Cureus · 16h

Polyvascular Atherosclerotic Disease: A Narrative Review of the Role of Systematic Bedside Vascular Examination

No original data or effect estimates are reported; the review argues that abnormal bedside findings should prompt selective ABI, duplex, CTA, MRA or cardiac testing rather than indiscriminate imaging.

Cardiology · Cureus · 17h

ARPA-H launches $63M effort to build FDA-authorized AI agents for heart failure care

Autonomous AI agents for heart failure could soon reach your clinic with FDA oversight, so watch how these tools are validated before adoption.

Cardiology · Fierce Healthcare · 20h

The future of RAS inhibitors

RAS inhibitors are moving beyond one approved drug for pancreatic cancer, so expect more targeted options for KRAS-mutant tumours in coming years.

Oncology · Fierce Biotech · 21h

FDA delays approval decision for Exelixis' tyrosine kinase inhibitor in colorectal cancer

A potential oral option added to atezolizumab for metastatic colorectal cancer is pushed back, so keep current regimens unchanged for now.

Oncology · Fierce Biotech · 22h

Tricuspid Stenosis Due to Cardiac Sarcoma

Echocardiography showed a large right atrial mass obstructing tricuspid inflow plus significant pericardial effusion; resection confirmed biphasic synovial sarcoma. Postoperatively he developed atrial flutter with left ventricular dysfunction needing cardioversion.

Cardiology · Cureus · 22h

Variability of Nutritional Status During Hematopoietic Stem Cell Transplantation and Its Association With Clinical Outcomes: An Ambispective Observational Study From India

Mean weight fell from -1.80% at day 0 to -7.65% at day +30. At day +60, weight loss was greater with viral infections (-14.7% vs -5.4%; p=0.03) and stays >36 days (-14.6% vs -5.3%; p=0.025).

Oncology · Cureus · 22h

STAT+: An AI tool aims to catch harder-to-detect heart attacks in EKGs

An AI ECG reader cleared to flag occult coronary occlusion could catch NSTEMI and posterior MI patterns that clinicians and standard algorithms miss.

Cardiology · STAT News — Health Tech · 23h

Lower Extremity Salvage Through Dextranomer Debridement and Evolution Toward a Functional Pincer in a Diabetic Foot: Experience in Rural Surgery

Serial topical dextranomer microbeads controlled exudate and fibrin, halted necrotic progression, and produced a clean granulating wound bed; the patient avoided proximal amputation after an 18-day hospital stay.

General Surgery · Cureus · 23h

Evaluation of Tooth Shade Selection With Conventional Methods and Artificial Intelligence-Integrated Methods: A Comparative Study

Exact shade agreement 78.2% with AI versus 49.1% conventional; Cohen's kappa 0.75 vs 0.43; accuracy 87.3% vs 74.5%; mean CIEDE2000 1.42 vs 1.76.

Medicine · Cureus · 1d

Hyperglycemic Hyperosmolar State As the Initial Presentation of Type 1 Diabetes Mellitus in an Adolescent: A Case Report

Glucose exceeded 1,000 mg/dL with hyperosmolality, dehydration and only mild acidosis; treatment caused marked glucose swings needing repeated insulin and dextrose titration.

Paediatrics · Cureus · 1d

Effectiveness and Patient Compliance of a Needle-Free Injection System in Controlled Ovarian Stimulation in IVF Cycles: A Real-World, Investigator-Initiated, Retrospective, Multicenter, Observational Study

Mean oocytes retrieved 13.4 ± 6.2 (r-FSH) versus 6.1 ± 7.6 (r-FSH+hMG); metaphase II oocytes 11.0 ± 5.4 versus 4.8 ± 6.3. Pain score 1.2 ± 1.3 for r-FSH, 3.6 ± 2.2 for hMG.

Obstetrics & Gynaecology · Cureus · 1d

Safety and Recovery Profile of Propofol-Based Intravenous Sedation for Endoscopic Retrograde Cholangiopancreatography in Adults: A Prospective Single-Center Observational Study

No oxygen desaturation or intubation (0/100, 95% CI 0-3.6). Airway maneuvers and procedural interruption in 5/100 (5%), PONV in 4/100 (4%). Median recovery 5 minutes.

Anaesthesiology · Cureus · 1d

Neurosurgical Outcomes of Epilepsy Surgery Between 2017 and 2025: A Retrospective ESSQ-19 Study From a Tertiary Care Center

ESSQ-19 summary score was 84.1±21.7. Surgical complication domain scored 89.2±21.1 and seizure control 85.0±27.6, while psychosocial domain scored lower at 79.9±24.1.

Neurology · Cureus · 1d

Preservation of Non-nidal Medial Veins During Microsurgical Resection of Cerebral Arteriovenous Malformations: Technical Considerations and Early Clinical Outcomes

Complete angiographic nidus eradication in all 16 patients, no perioperative mortality, and mRS 0-2 in 14 patients (87.5%). No delayed venous infarction or haemorrhagic transformation occurred.

Neurology · Cureus · 1d

Early Prognostic Value of the Freiburg Index of Post-Transjugular Intrahepatic Portosystemic Shunt Survival in Patients With Hepatocellular Carcinoma Undergoing Liver Transplantation

Pre-transplant FIPS may flag HCC patients at higher risk of early post-transplant death, helping you refine waitlist and perioperative counselling.

Gastroenterology · Cureus · 1d

A Structured, Auditable Taxonomy for Pharmacist-Identifiable Medication-Related Risk Signals in Routine Admission Data: A Retrospective Medication Safety Audit in a High-Risk Inpatient Cohort

Poor adherence 10 of 17; residual medication discrepancy 5 of 17; self-discontinuation 3 of 17; insulin instruction mismatch 2 of 17; suboptimal blood pressure control 9 of 13; suboptimal glycaemic control 5 of 8.

General Medicine · Cureus · 1d

Reverse Total Shoulder Arthroplasty in a 25-Year-Old Woman With Seropositive Rheumatoid Arthritis After Prior Age-Based Surgical Deferral

At two years, ASES score 80/100 (pain 3/10, ADL 27/30) and SANE 95%, with no instability, infection, or mechanical failure.

Orthopaedics · Cureus · 1d

Pediatric Headache: A Practical Approach to Clinical Diagnosis and Management

No numerical results reported. Diagnosis rests on structured history, disability assessment and examination; red flags prompt risk stratification rather than reflexive neuroimaging

Paediatrics · Cureus · 1d

Mpox (Formerly Known as Monkeypox) in Dermatological Practice: Presentation of a Series of Four Clinical Cases at a Referral Hospital

Presentations ranged from disseminated vesiculopustular eruptions with systemic symptoms to strictly localised painful perianal lesions without prodrome; one case was initially misdiagnosed as herpes.

General Medicine · Cureus · 1d

Unusual Vascular Claudication in a Seronegative Patient: Raynaud's Phenomenon or Atypical Buerger Disease

Proximal vessels were patent with sluggish distal forearm flow and diminutive radial and ulnar arteries at the wrist; hypercoagulable and vasculitis workup was unrevealing and inflammatory markers stayed normal.

General Medicine · Cureus · 1d

Oral Health in Hospitalized Adults: Clinical Outcomes and the Role of Dental Expertise

Strongest evidence is for respiratory outcomes; recent randomised evidence gives preliminary support for structured multicomponent oral care reducing non-ventilator hospital-acquired pneumonia on general wards. Chlorhexidine evidence remains inconsistent.

General Medicine · Cureus · 1d

Disseminated Pulmonary Coccidioidomycosis Presenting as a Wedge-Shaped Necrotic Mass Mimicking Malignancy

CT showed a 7.3 × 5.4 cm wedge-shaped necrotic right middle lobe mass with bilateral nodules; biopsy showed granulomatous inflammation with fungal elements, confirmed by serology and BAL PCR

General Medicine · Cureus · 1d

Rapid Resolution of Apophenic Psychosis With Low-Dose Olanzapine in Very Late-Onset Schizophrenia-Like Psychosis

Limited response to quetiapine; rapid and sustained remission on low-dose olanzapine, with symptom recurrence after dose reduction supporting a primary psychotic process

Psychiatry · Cureus · 1d

Comparative Evaluation of Concurrent Carboplatin-Paclitaxel Versus Cisplatin-Etoposide Chemoradiotherapy in Unresectable Non-small Cell Lung Cancer: A Prospective Randomized Study

Tumour-response distribution favoured EP (p=0.029). 12-month PFS 40.0% EP versus 25.0% PC (p=0.206); 12-month OS 80.0% versus 56.3% (p=0.144). EP caused more severe anemia, thrombocytopenia and esophagitis.

Oncology · Cureus · 1d

Factors Influencing Adherence to Mammography Screening Guidelines Among Women From Diverse Cultural Backgrounds: A Systematic Review

Higher adherence was associated with higher educational level, health insurance coverage, older age, and advice by a healthcare professional. Barriers included screening costs, lack of insurance, communication difficulties, cultural and fatalistic beliefs, fear and embarrassment.

Obstetrics & Gynaecology · Cureus · 1d

Right Coronary Artery Thrombosis Causing ST-Elevation Myocardial Infarction After a Coronary Artery Disease Reporting and Data System Score of 0, With Disseminated Intravascular Coagulation During Idiopathic Acute Pancreatitis: A Case Report

A 99% thrombotic subtotal occlusion of the mid-right coronary artery caused inferior STEMI; coronary CT angiography five months earlier had shown an Agatston score of 0 and CAD-RADS 0.

Cardiology · Cureus · 2d

Mass Effect Score Associations in Comatose Trauma Patients With Intracranial Hemorrhage Requiring Mechanical Ventilation: A Retrospective Study

Mortality and adverse outcomes were associated with MES ≥2 (both p 0.05). Failure to follow commands at three months was also associated with MES ≥2 (p 0.05).

Neurology · Cureus · 2d

Weekly Rundown: Cleveland Clinic taps Luminai for AI automation; Quest brings lab testing to Apple Health

US health systems are embedding AI into scheduling and lab-result delivery; expect similar vendor pitches to reach Indian hospitals and clinics within months.

Medicine · Fierce Healthcare · 2d

When Speech Signals Wilson Disease: A Case Report

Kayser-Fleischer rings, reduced serum ceruloplasmin, elevated 24-hour urinary copper, decompensated liver disease, and MRI signal changes in basal ganglia, thalami, and periventricular white matter confirmed Wilson disease; D-penicillamine and zinc led to clinical improvement

Neurology · Cureus · 2d

STAT+: Can AI save rural health care?

Federal bets on AI for rural care may shape what tools reach your understaffed district hospital, though none are proven yet.

General Medicine · STAT News — Health Tech · 2d

Graph AI raises $13.3 Mn in Series A round led by Insight Partners

Company claims live deployments reduced adverse event case processing turnaround from more than three hours to under 10 minutes, a reduction of over 90%, and lowered operating costs by up to 66%

Medicine · Entrackr · 2d

Clinical and Radiographic Success of Pulpotomy in Permanent Teeth With Irreversible Pulpitis: A Systematic Review

Across 16 included studies, pulpotomy consistently gave favourable clinical and radiographic success in permanent teeth with irreversible pulpitis, especially with MTA, Biodentine, CEM and other bioceramics.

General Medicine · Cureus · 2d

Comparison of Fluoroscopy Use Between Two Radiographic Overlay Techniques for Limb Length and Femoral Offset Assessment During Direct Anterior Approach Total Hip Arthroplasty

Unadjusted fluoroscopy time was 60.4 ± 21.2 versus 55.9 ± 19.6 seconds (P = 0.17) and radiation 15.4 ± 13.3 versus 13.0 ± 9.0 mGy (P = 0.17). Time-adjusted ipsilateral use was lower (P = 0.0025).

Orthopaedics · Cureus · 2d

Improving Antibiotic Stewardship Through a Retrospective Study of the Diagnostic Value of Nasal Methicillin-Resistant Staphylococcus aureus Polymerase Chain Reaction for Pneumonia in Intensive Care Unit Settings

Nasal MRSA PCR sensitivity for MRSA in lower respiratory cultures was 90% (18/20); positive predictive value was only 60% (18/30).

General Medicine · Cureus · 2d