Archive

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Genome Editing in Inherited Cardiovascular Diseases: Therapeutic Advances, Emerging Editing Platforms, and Translational Challenges

No trial results are reported. Preclinical work corrected MYBPC3 and MYH7 in HCM, targeted TTN, RBM20 and LMNA in DCM, restored ion channel function, and modulated PCSK9, LDLR and ANGPTL3.

Cardiology · Cureus · 12h

Polyvascular Atherosclerotic Disease: A Narrative Review of the Role of Systematic Bedside Vascular Examination

No original data or effect estimates are reported; the review argues that abnormal bedside findings should prompt selective ABI, duplex, CTA, MRA or cardiac testing rather than indiscriminate imaging.

Cardiology · Cureus · 18h

ARPA-H launches $63M effort to build FDA-authorized AI agents for heart failure care

Autonomous AI agents for heart failure could soon reach your clinic with FDA oversight, so watch how these tools are validated before adoption.

Cardiology · Fierce Healthcare · 21h

Tricuspid Stenosis Due to Cardiac Sarcoma

Echocardiography showed a large right atrial mass obstructing tricuspid inflow plus significant pericardial effusion; resection confirmed biphasic synovial sarcoma. Postoperatively he developed atrial flutter with left ventricular dysfunction needing cardioversion.

Cardiology · Cureus · 22h

STAT+: An AI tool aims to catch harder-to-detect heart attacks in EKGs

An AI ECG reader cleared to flag occult coronary occlusion could catch NSTEMI and posterior MI patterns that clinicians and standard algorithms miss.

Cardiology · STAT News — Health Tech · 24h

Right Coronary Artery Thrombosis Causing ST-Elevation Myocardial Infarction After a Coronary Artery Disease Reporting and Data System Score of 0, With Disseminated Intravascular Coagulation During Idiopathic Acute Pancreatitis: A Case Report

A 99% thrombotic subtotal occlusion of the mid-right coronary artery caused inferior STEMI; coronary CT angiography five months earlier had shown an Agatston score of 0 and CAD-RADS 0.

Cardiology · Cureus · 2d

Temporary Left Ventricular Unloading With Impella as a Bridge to Emergency Surgery for Acute Mitral Bioprosthetic Failure

Cardiac index and mixed venous oxygen saturation rose and oxygenation held on less inspired oxygen; mean pulmonary artery pressure stayed around 40 mmHg and did not keep climbing

Cardiology · Cureus · 2d

STAT+: ARPA-H to invest $62 million to develop FDA-authorized AI to help treat heart failure

AI-guided heart failure therapy could soon be FDA-authorized, potentially changing how you titrate medications and monitor patients.

Cardiology · STAT News — Health Tech · 3d

Abbott garners FDA nod for its TactiFlex catheter to treat AFib

A new ablation catheter option for AFib may improve procedural flexibility and outcomes in your electrophysiology cases.

Cardiology · Fierce Biotech · 3d

Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial.

Mitiperstat (pooled doses) did not improve KCCQ-TSS (placebo-corrected difference -1.4 points, 95% CI -3.9 to 1.2; P=0.29) or 6MWD (3.8 m, 95% CI -3.1 to 10.8; P=0.28) or any secondary endpoint.

Cardiology · Nature Medicine · 3d

Ranolazine in Chronic Stable Angina: A Systematic Review and Meta-Analysis

Exercise duration increased by 33.1 seconds (95% CI 27.3-38.9). MI risk reduced (RR 0.91; 95% CI 0.84-0.98), CABG (RR 0.55; 95% CI 0.35-0.86), any revascularization (RR 0.77; 95% CI 0.64-0.91). Adverse events more frequent (RR 1.45; 95% CI 1.27-1.66).

Cardiology · Cureus · 5d

Novartis Lp(a) drug fails to lower cardiovascular risk in closely watched ph. 3 trial

Despite lowering Lp(a), this drug did not cut heart attack or stroke risk—so don't start checking Lp(a) routinely yet.

Cardiology · Fierce Biotech · 7d

Dapagliflozin and Risk of Perioperative Acute Kidney Injury in Cardiac Surgery

Perioperative AKI after cardiac surgery is common; this trial tests whether continuing SGLT2 inhibitors changes that risk, informing your pre-op medication decisions.

Cardiology · JAMA · 11d

SGLT2 Inhibitors for Prevention of AKI

Starting dapagliflozin the day before elective cardiac surgery may cut postoperative AKI—consider timing and renal risk in your surgical patients.

Cardiology · JAMA · 11d

Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery Research Summary

If dapagliflozin cuts post-op AKI, you can start it pre-surgery to protect kidneys in high-risk cardiac patients.

Cardiology · JAMA · 11d

Boston Scientific halts sales of angiographic catheters amid 2 serious injuries

Check your stock of Imager II catheters; tip defect may cause serious injury—stop use and follow recall instructions.

Cardiology · Fierce Biotech · 11d

ESC: Alnylam's next-gen silencer sees silver linings after fallout of AZ, Ionis trial in ATTR-CM

For cardiologists managing ATTR-CM, this suggests RNAi may still benefit patients on tafamidis despite the Wainua failure—watch for confirmatory data.

Cardiology · Fierce Biotech · 12d

ESC26: AstraZeneca's heart failure drug shows promise in ph. 2 trial

Oral relaxin agonist improved cardiac function in chronic heart failure—watch for a potential new add-on beyond standard therapy.

Cardiology · Fierce Biotech · 12d

Targeted left ventricular lead placement in biventricular pacing for heart failure: a national, multicentre, double-blind, randomised controlled trial in Denmark.

Primary endpoint occurred in 139/499 (28%) intervention vs 128/501 (26%) control (HR 1.10, 95% CI 0.86-1.39; p=0.45). No benefit.

Cardiology · Lancet · 13d

Catheter-Directed Thrombolysis in Intermediate-High-Risk Pulmonary Embolism.

Primary composite event occurred in 2/280 (0.7%) thrombolysis vs 19/278 (6.8%) standard care (RR 0.10, 95% CI 0.02-0.44, P<0.001), driven by reduced cardiorespiratory decompensation. Major bleeding 1.4% vs 2.2% (P=0.54).

Cardiology · NEJM · 13d

Short-term effects of combinations of heart failure therapies on blood pressure, kidney function and serum potassium.

In HFrEF, ARNI+SGLT2i+sMRA reduced SBP by -9.2 (-10.6 to -7.8) mmHg, eGFR by -6.8 (-7.9 to -5.4) ml/min/m2, increased potassium by +0.30 (0.25-0.35) mmol/l. In HFmrEF/HFpEF, SGLT2i+sMRA reduced SBP -5.9 (-7.3 to -4.6) mmHg, eGFR -7.7 (-8.9 to -6.4), potassium +0.34 (0.29-0.38).

Cardiology · Nature Medicine · 13d

FDA Approves First Oral PCSK9 Inhibitor to Lower LDL Cholesterol in Adults with High Cholesterol

Offers an oral alternative to injectable PCSK9 inhibitors, potentially improving adherence for your high-cholesterol patients who avoid injections.

Cardiology · FDA — Press Announcements · 17 Jul

WatchMate Software — Anumana, Inc. (FDA K260300)

AI ECG analysis may flag cardiac risk earlier in routine radiology workflows, prompting timely cardiology referral.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 15 Jun

EchoNext — Pathwai, Inc. (FDA K260332)

AI-assisted echo analysis may speed up your workflow and flag subtle findings, but clinical validation is limited—use as an adjunct, not a replacement.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 8 Jun

ZEUS Platform (FG0501US) — iRhythm Technologies, Inc. (FDA K252859)

FDA-cleared AI platform for ECG analysis may streamline arrhythmia detection in your practice, potentially reducing manual review time.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 29 May

PCWP Analysis Software — Cardiosense, Inc. (FDA DEN250057)

This AI software estimates pulmonary capillary wedge pressure non-invasively, potentially reducing need for invasive catheterization in heart failure patients.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 22 May

OPTIS Mobile Next Imaging System (1014932); OPTIS Integrated Next Imaging System (1014933); Ultreon 3.0 Software Upgrade Kit (ULTR300001) — ABBOTT MEDICAL (FDA K253459)

For interventional cardiologists, this clearance expands AI-guided OCT imaging options, potentially improving stent placement accuracy and reducing procedural complications.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 24 Apr

Novasight Hybrid System — Conavi Medical, Inc. (FDA K252945)

Gives you a single catheter for combined IVUS and OCT, so you can size vessels and assess plaque without swapping devices during PCI.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 17 Apr

ECG-AI Cardiac Amyloidosis (CA) 12-Lead Algorithm (1040) — Anumana, Inc. (FDA K253801)

This AI ECG algorithm flags cardiac amyloidosis earlier from a routine 12-lead, enabling timely diagnosis and treatment in a condition often missed.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 7 Apr

ECG-AI Pulmonary Hypertension (PH) 12-Lead algorithm (1020) — Anumana, Inc. (FDA K252360)

This AI ECG algorithm may help screen for pulmonary hypertension from a routine 12-lead, enabling earlier referral and diagnosis in primary care.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 28 Mar

Automated Aortic Stenosis Software (AutoAS) — GE Medical Systems Ultrasound & Primary Care Diagnostics, LLC (FDA K254161)

AutoAS automates aortic stenosis grading on ultrasound, potentially reducing measurement variability and helping you triage valve disease faster in clinic.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 27 Mar

Tyto Stethoscope (G3) — Tyto Care , Ltd. (FDA K252089)

Lets you capture and share heart sounds remotely, supporting tele-consultations and follow-ups without an in-person visit.

Cardiology · FDA — AI/ML-Enabled Medical Devices · 12 Mar