Archive

Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.

An oral pyruvate kinase activator that raises haemoglobin and cuts haemolysis could give sickle cell patients a disease-modifying pill instead of transfusions and hydroxyurea alone.

General Medicine · Lancet · 4d

Tarlatamab-Durvalumab Maintenance for Extensive-Stage Small-Cell Lung Cancer.

Median overall survival 21.1 months with tarlatamab-durvalumab versus 12.7 months with durvalumab (HR 0.42; 95% CI 0.32 to 0.54; P<0.001). Median progression-free survival 7.4 versus 1.9 months (HR 0.34; 95% CI 0.28 to 0.42).

Oncology · NEJM · 4d

Prenatal Opioid Exposure and Subsequent Risk of Fractures in Children: An Emulated Target Trial Using a Nationwide Birth Cohort.

If prenatal opioid exposure raises childhood fracture risk, exposed infants warrant closer growth and injury surveillance — though this Korean cohort needs replication before changing Indian practice.

Paediatrics · Indian pediatrics · 4d

Nirsevimab Implementation and Primary Management of Lower Respiratory Tract Infections in Infants in Spain: A Quasi-Experimental Study.

Spanish primary-care data on how infant RSV LRTI visits and management shifted after nirsevimab rollout — useful when counselling Indian parents on monoclonal antibody prophylaxis.

Paediatrics · Indian pediatrics · 4d

Comparative Interpretation of Pediatric Electrocardiograms by Large Language Models and a Pediatrician.

Before you let an AI read a child's ECG, know that general-purpose chatbots misread paediatric tracings in characteristic ways a paediatrician does not.

Paediatrics · Indian pediatrics · 4d

Transparent Film Dressing Versus Microporous Paper Tape for Temperature Probe Fixation in Preterm Neonates: A Randomized Controlled Trial.

Any skin damage was comparable: 41/64 (64.1%) with paper tape versus 38/64 (59.4%) with film dressing, P=0.585. Dryness was more frequent with paper tape (54.7% vs 31.3%, P=0.007); erythema and breakdown did not differ.

Paediatrics · Indian pediatrics · 4d

Anthropometric and Metabolic Changes and Comorbidity Remission Rates After Predominantly Sleeve Gastrectomy at a Referral Center in Southwestern Colombia: A Retrospective Cohort Study, 2022-2023

Real-world Latin American data on sleeve gastrectomy remission rates helps you set realistic expectations for diabetes and hypertension improvement when counselling bariatric referrals.

General Surgery · Cureus · 4d

Clinical Survival and Failure Patterns of Stainless Steel Crowns Under General Anesthesia in Pediatric Dentistry: A Systematic Review

Knowing SSC failure rates after GA placement helps you decide which primary molars need crowns versus fillings, and when repeat anaesthesia is likely.

Paediatrics · Cureus · 4d

Diagnostic Accuracy of Computed Tomography for Radiographically Occult Scaphoid Fractures and Concordance With Magnetic Resonance Imaging: A Systematic Review

Pooled CT sensitivity 79% (95% CI 61.5-89.8%) and specificity 94.4% (95% CI 82.1-98.4%); second-reader sensitivity analysis gave 69.2% (95% CI 48.0-84.6%) with specificity 94.4%.

Orthopaedics · Cureus · 4d

Very Early-Onset Prosthetic Valve Endocarditis Following Transcatheter Aortic Valve Implantation Complicated by an Aorto-Left Atrial Fistula and Aortic Root Pseudoaneurysm

Endocarditis within 48 hours of TAVI can present with fistula and pseudoaneurysm, so keep it on the differential when a post-TAVI patient deteriorates early.

Cardiology · Cureus · 4d

Psychiatric Adverse Events Associated With Bimekizumab: A Disproportionality Analysis of the FDA Adverse Event Reporting System

If you prescribe bimekizumab for psoriasis, this FAERS analysis tells you whether real-world depression and suicidality reports match the label warning, and what to monitor.

Psychiatry · Cureus · 4d

Remote Endocrinology Support for Primary Care Clinicians Managing Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials

Evidence on remote specialist support for primary-care diabetes care is still uncertain, so don't assume e-consult or tele-endocrinology models improve HbA1c until trials show it.

Endocrinology · Cureus · 4d

Cerebral Infarction As the Presenting Feature of Janus Kinase 2 (JAK2) V617F-Positive Polycythemia Vera: A Case Report

In young stroke patients without usual risk factors, check a haemoglobin and JAK2 — undiagnosed polycythemia vera is a treatable cause of arterial infarction.

Neurology · Cureus · 4d

Primary Total Knee Arthroplasty Using Revision-Type Stems for Distal Femoral Bone Compromise Following Previous Fracture Fixation: A Report of Two Cases and Narrative Review

At six months both knees were stable and well-aligned; KOOS-12 scores were 54 and 58, SANE scores 60% and 80%. Primary polyethylene insert was retained without increasing prosthetic constraint.

Orthopaedics · Cureus · 4d

Asphyxiating Floor-of-Mouth Hematoma Secondary to Rivaroxaban

Nasofibroscopy showed critical supraglottic narrowing with failed orotracheal intubation; emergency tracheostomy secured the airway. Without andexanet alfa or prothrombin complex concentrate, the hematoma regressed over 48 hours and she was decannulated on day seven.

Anaesthesiology · Cureus · 4d

Robotic-Assisted Versus Open Transversus Abdominis Release (TAR) for Complex Ventral Hernia Repair: A Systematic Review and Meta-Analysis

Robotic TAR reduced overall complications (OR 0.48; 95% CI 0.34-0.68), surgical site occurrences (OR 0.43; 95% CI 0.25-0.75), SSIs (OR 0.45; 95% CI 0.21-0.96) and length of stay (MD -3.76 days; 95% CI -4.68 to -2.84), with longer operative times (MD +53.62 min).

General Surgery · Cureus · 4d

Effects of Intracanal Medicaments on Postoperative Pain: A Comparative Study of Calcium Hydroxide, Triple Antibiotic Paste, and Chlorhexidine

Choice of intracanal medicament between visits may affect how much pain your endodontic patients report; this head-to-head comparison of four regimens gives you comparative data.

Medicine · Cureus · 4d

Postoperative Complications After the Surgical Management of Panfacial Fractures: A Retrospective Cohort Study

Quantifies complication patterns after panfacial fracture repair, helping you counsel patients on infection and revision risk and plan closer postoperative follow-up.

General Surgery · Cureus · 4d

STAT+: AI drug firm Pathos raises $237 million, pushing valuation to $3 billion

If AI-guided discovery using large tumour datasets yields candidates faster, oncology trial options for your patients could widen within a few years.

Oncology · STAT News — Health Tech · 4d

Emerging Physiotherapy and Rehabilitation Strategies for Patellofemoral Pain Syndrome: A Systematic Review

Beneficial effects were reported for pain, muscle strength, functional performance, balance, neuromuscular control and lower-limb biomechanics, but effects varied by intervention, comparator, outcome and assessment time point; no pooled estimate was reported.

Orthopaedics · Cureus · 4d

Perioperative Management of Decompensated Peripartum Cardiomyopathy With Severe Left Ventricular Dysfunction: A Case Report

Dyspnea at 34 weeks is usually dismissed as pregnancy; this case shows how to anaesthetise and deliver a woman with an EF near 20% without decompensating her.

Anaesthesiology · Cureus · 4d

Artificial Intelligence for Automated Continuous Quantification of Left Ventricular Ejection Fraction From Standard Adult Transthoracic Echocardiography: A Systematic Review

Before trusting an automated EF, know that agreement with reference varies across AI tools — verify against your own lab's values rather than adopting a single vendor number.

Cardiology · Cureus · 4d

When Artificial Intelligence Becomes Irreplaceable: A Proposed Framework for AI Attachment Dysregulation

Patients increasingly form intense bonds with AI companions; this framework helps you distinguish normal distress after loss of an AI relationship from actual psychopathology.

Psychiatry · Cureus · 4d

Coblation, Cold Steel, and Diathermy Tonsillectomy: A Comparative Review of Surgical Outcomes

Technique choice changes post-tonsillectomy pain and secondary haemorrhage rates; this review compares coblation, cold steel and diathermy so you can counsel patients and pick your method.

General Surgery · Cureus · 4d

Clinical Outcomes and Safety of Spatially Fractionated Radiotherapy for Malignant Tumors: A Systematic Review and Evidence Map

SFRT delivers ablative central doses with sparing of surrounding tissue; this map shows where comparative evidence is still missing before you adopt it for bulky or radioresistant tumors.

Oncology · Cureus · 4d

Centre directs states to enforce ban on reuse of single-use medical devices

Hospitals you work in or refer to may be reprocessing single-use catheters and devices; check your institution's practice before the next DGHS inspection.

General Surgery · ETHealthworld · 4d

Intramuscular Vitamin D2 in Patients With Systemic Sclerosis Not Responding to Oral Supplementation: A Retrospective Observational Case Series

If your scleroderma patient stays below 30 ng/mL on oral cholecalciferol, gut malabsorption may be the cause; IM ergocalciferol is a practical alternative worth trying.

General Medicine · Cureus · 4d

Restrictive Potassium Supplementation Strategy in a General Intensive Care Unit: A Before-and-After Quality Improvement Audit in a Mixed Critical Care Population

Raising your potassium replacement threshold in mixed ICU patients may cut unnecessary supplementation without harm, extending TIGHT K's cardiac-surgery findings to general critical care.

Anaesthesiology · Cureus · 4d

Incidental Metastatic High-Grade Neuroendocrine Carcinoma Diagnosed by Liver Biopsy During Cholecystectomy: A Case Report

A reminder that benign-looking gallbladder symptoms can mask metastatic NEC; consider intraoperative liver findings and biopsy before closing.

General Surgery · Cureus · 4d

Spontaneous Isolated Superior Mesenteric Artery Dissection Presenting as Paralytic Ileus: A Case Report

SISMAD can present as ileus without classic pain out of proportion, so consider mesenteric CTA before labelling unexplained distension as simple obstruction.

General Surgery · Cureus · 4d

A Systematic Review With Narrative Synthesis of Antibiotic Prophylaxis in Orthopaedic Surgery: Clinical, Microbiological, Histopathological, and Antimicrobial Resistance Outcomes

Wide variation persists in agent, dose, timing and duration of surgical prophylaxis — this synthesis maps the evidence so you can standardise your implant and arthroplasty protocols.

Orthopaedics · Cureus · 4d

An Uncommon Communication: Hepatogastric Fistula in a Young Male Patient With a Pyogenic Liver Abscess

A left-lobe pyogenic abscess that fails to settle on antibiotics should raise fistula suspicion; erosion into the stomach changes drainage strategy and needs imaging, not more conservative waiting.

Gastroenterology · Cureus · 4d

Efficacy and Safety of Revefenacin Versus Glycopyrronium in Indian Chronic Obstructive Pulmonary Disease (COPD) Patients: A Randomized, Active-Controlled, Phase III Trial

A once-daily nebulized LAMA now has Indian efficacy and safety data, giving an option for COPD patients who cannot use handheld inhalers reliably.

General Medicine · Cureus · 4d

Central Nervous System Progression During Longitudinal Treatment of Anaplastic Lymphoma Kinase-Positive Non-small Cell Lung Cancer: A Real-World Cohort Study

CNS progression still occurs on CNS-active ALK-TKIs; track cumulative drug exposure across lines, not just first-line choice, when timing MRI surveillance.

Oncology · Cureus · 4d

Centre flags data gap, regulatory hurdles in curbing hospital mark-ups

Consumable mark-ups of 100-1,000% hit your patients' bills directly, but no national margin data exists yet to justify price caps you may be asked about.

General Medicine · ETHealthworld · 5d

Microsoft develops AI tool that can diagnose 'sequentially' like a doctor

A simulated panel of specialists that sequences history, tests and orders could change how undifferentiated cases are worked up — but it is unvalidated in real clinics.

General Medicine · ETHealthworld · 5d

Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke.

If late-window thrombectomy still improves outcomes in selected patients with salvageable tissue, your 24-hour treatment cutoff for transfer and imaging decisions needs revisiting.

Neurology · NEJM · 5d

Ravulizumab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial.

Terminal complement blockade may slow proteinuria and nephron loss in IgA nephropathy, offering a targeted alternative to renin-angiotensin blockade alone.

General Medicine · NEJM · 5d

Trastuzumab Rezetecan in ERBB2-Low Advanced Breast Cancer: The HORIZON-Breast06 Randomized Clinical Trial.

If the ADC beats physician's-choice chemo in ERBB2-low disease, it opens a targeted option for the large HER2-low group currently offered conventional chemotherapy.

Oncology · JAMA · 5d

Remibrutinib versus teriflunomide in relapsing multiple sclerosis (REMODEL-1 and REMODEL-2): two randomised, phase 3 trials.

An oral, CNS-penetrant BTK inhibitor with an active comparator against teriflunomide could give your relapsing MS patients a new oral option if the event-driven results hold.

Neurology · Lancet · 5d