Archive

Tyra rolls toward pivotal bladder cancer study even as midphase data deflates stock

Dabogratinib's complete response rate missed analyst targets, so watch for confirmatory data before considering it for FGFR-altered bladder cancer patients.

Oncology · Fierce Biotech · 3d

Differences Between Oncological and Non-oncological Patients Referred to an In-Hospital Palliative Care Support Team: A Retrospective Cohort Study in Northern Portugal

In-hospital mortality was 48.9% (44/90) in non-oncological versus 19.8% (21/106) in oncological patients; transfer to a specialist palliative care unit was 16.7% (15/90) versus 42.5% (45/106).

General Medicine · Cureus · 3d

Kura creates Lilly-backed spinout armed with $50M to advance next-gen diabetes therapy

A new Lilly-backed spinout with $50M may bring a next-gen diabetes option—watch for efficacy or safety gains over current therapies.

Endocrinology · Fierce Biotech · 3d

Opinion: Autonomous AI will beat AI-assisted physicians at some medical tasks by 2030

Anticipate AI outperforming you in diagnosis and planning by 2030; prepare to shift your role toward oversight and complex cases.

Medicine · STAT News — Health Tech · 3d

Opinion: AMA CEO: AI won’t replace doctors — it will work alongside them

AMA’s stance signals AI as a clinical ally, not replacement—shaping how Indian regulators and hospitals may adopt AI tools.

Medicine · STAT News — Health Tech · 3d

STAT+: Can AI fix health care? In the chaos of emergency rooms, the technology comes up short

AI tools underdeliver in real ED chaos; don't rely on them for critical triage decisions yet.

General Medicine · STAT News — Health Tech · 3d

Abbott garners FDA nod for its TactiFlex catheter to treat AFib

A new ablation catheter option for AFib may improve procedural flexibility and outcomes in your electrophysiology cases.

Cardiology · Fierce Biotech · 3d

Characterization of Delirium in an Intensive Care Unit: Real-World Data Based on the Application of the Confusion Assessment Method

66 of 788 admissions (8.4%) had a positive CAM-ICU. Delirium patients were older (median 71 vs 68 years), had longer ICU stay (median 8 vs 3 days), and higher invasive ventilation rate (62.5% vs 40.3%).

Anaesthesiology · Cureus · 3d

Vicarious Contrast Medium Excretion Mimicking Acute Hemorrhage: Don't Call the Interventional Radiologist!

Repeat CT showed hyperdense material in gallbladder and small bowel suggesting recurrent bleeding; unenhanced images showed the material preceded the second contrast dose and was unchanged after it, confirming benign vicarious excretion.

Radiology · Cureus · 3d

A Rare Event Causing Blindness in an Unrecognised Pregnancy: A Case Report

Visual acuity was 2/60 right and 3/60 left at presentation, with optic disc swelling, macular star, Purtscher flecken and serous macular detachment; acuity remained poor at two months despite high-dose IV methylprednisolone and oral prednisolone taper.

Medicine · Cureus · 3d

Beeline flies into phase 3 as oral lupus drug soars past placebo

An oral option for lupus could reduce injection burden; watch for phase 3 efficacy and safety data before changing practice.

General Medicine · Fierce Biotech · 3d

Evommune gives up hope for MRGPRX2 antagonist to treat itch after latest phase 2 fail

MRGPRX2 blockade fails again in itch—no new option for chronic pruritus patients; consider alternative pathways in refractory cases.

Medicine · Fierce Biotech · 3d

Diagnostic Diplopia: Isolated Oculomotor Nerve Palsy With Normal Imaging

When imaging is normal in isolated oculomotor palsy, don't settle for microvascular cause—consider vasculitis, aneurysm, or infiltrative disease before discharging.

Neurology · Cureus · 3d

ICMR-NIV study detects insecticide resistance in dengue vector mosquitoes in parts of Pune

If you manage dengue cases, expect control failures in Pune; consider alternative vector control and patient counselling on prevention.

General Medicine · ETHealthworld · 3d

Solstice rises with $225M series A to advance next-gen CTLA-4 immunotherapy into phase 2

This funding accelerates a next-gen CTLA-4 inhibitor into phase 2, potentially offering better-tolerated checkpoint therapy for your cancer patients.

Oncology · Fierce Biotech · 3d

Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival and event-free survival by pathological response in a global, randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

Overall survival significantly improved with durvalumab versus placebo (hazard ratio 0·78, 95% CI 0·63-0·96; p=0·021). Treatment-related deaths occurred in 6 (1%) versus 2 (<1%).

Oncology · Lancet · 3d

Effect of exercise on bone health in middle aged and older adults: hierarchical network meta-analysis of randomised trials.

Lumbar spine BMD rose with brisk walking or jogging (0.013 g/cm2, 95% CrI 0.006 to 0.021) and combined aerobic-resistance exercise (0.013, 0.010 to 0.016). Mixed aerobic exercise reduced fractures (OR 0.29, 0.11 to 0.78).

Orthopaedics · BMJ · 3d

Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial.

Mitiperstat (pooled doses) did not improve KCCQ-TSS (placebo-corrected difference -1.4 points, 95% CI -3.9 to 1.2; P=0.29) or 6MWD (3.8 m, 95% CI -3.1 to 10.8; P=0.28) or any secondary endpoint.

Cardiology · Nature Medicine · 3d

Commensal Nakaseomyces glabratus migrates into prostate tumors to accelerate cancer progression.

N. glabratus was enriched in fecal, blood and tumour samples of castration-resistant prostate cancer patients and correlated with poor overall survival; in castrated mice it accelerated progression via PMN-MDSC infiltration.

Oncology · Nature cancer · 3d

Inhaled siRNA therapy targeting RAGE for pulmonary inflammation: a first-in-human randomized trial.

ARO-RAGE was safe and well tolerated with no clinically relevant changes in chest x-ray, pulmonary function or systemic inflammation; prolonged dose-responsive decreases in serum and bronchoalveolar lavage sRAGE indicated target engagement.

Medicine · Nature Medicine · 3d

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants: The AIROPLANE Cluster Randomized Crossover Trial.

Ongoing respiratory support when leaving the delivery room: 700 of 964 (72.6%) with Fio2 0.30 vs 626 of 854 (73.3%) with Fio2 0.21; risk difference -0.83 (95% CI, -4.33 to 2.67).

Paediatrics · JAMA · 3d

Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

MWT sleep latency rose 14.3-19.8 minutes with oveporexton versus -0.4 to -0.8 with placebo; ESS fell 9.7-11.8 versus 1.5-1.7; cataplexy fell 79.0-88.8% versus 27.7-39.1% (all P<0.001).

Neurology · NEJM · 3d

Nephrotic Syndrome During Ipilimumab Plus Nivolumab Therapy for Sarcomatoid Malignant Pleural Mesothelioma: A Case Report of Nivolumab Rechallenge Without Recurrence of Nephrotic Syndrome

Nephrotic syndrome emerged during ipilimumab plus nivolumab and resolved with drug cessation plus prednisolone. Nivolumab alone, given with a tapering prednisolone dose after tumour regrowth, did not reproduce nephrotic syndrome.

Medicine · Cureus · 3d

Cytomegalovirus (CMV) Central Nervous System Infection and Recurrent Posterior Circulation Ischemic Strokes in an Immunocompetent Patient

CSF showed lymphocytic meningitis, elevated protein, normal glucose; CMV genome detected. Ganciclovir normalized CSF, but patient died of hemorrhagic complications.

Medicine · Cureus · 4d

Spontaneous Tumor Lysis Syndrome in Refractory Metastatic Esophageal Adenocarcinoma Presenting With Septic Shock

Laboratory evaluation showed hyperuricemia (18.1 mg/dL), hyperkalemia (7.6 mmol/L), hyperphosphatemia (7.8 mg/dL), and acute kidney injury; findings met Cairo-Bishop thresholds for TLS.

Medicine · Cureus · 4d

Chylous Ascites Following Thoracic Drainage in a Patient With Previously Undiagnosed Cirrhosis

Chylous ascites developed within days of Seldinger chest drain insertion; resolved with dietary fat restriction and supportive care.

Medicine · Cureus · 4d

Repeated Thrombolysis Using Tenecteplase in a Patient With Early Recurrent Ischaemic Stroke

Patient received tenecteplase twice and had good outcome; no specific efficacy or safety numbers reported

Medicine · Cureus · 4d

Outcomes of Open, Percutaneous, and Closed Treatment of Isolated Mandibular Condylar Fractures

Across severity strata, 30-day readmission rates ranged from 4.8% to 8.3%; open, percutaneous, and closed approaches did not differ significantly (all p ≥ 0.711).

Medicine · Cureus · 4d

Longitudinal COVID-19 Vaccination Records and SARS-CoV-2 Infection Among Older Long-Term Care Facility Residents in Okinawa, Japan: A Retrospective Descriptive Study

Linked documented infection occurred in 89/232 residents (38.4%; 95% CI, 32.3%-44.8%). Recurrent infection occurred in 24/89 residents (27.0%; 95% CI, 18.8%-37.0%).

Medicine · Cureus · 4d

Transcatheter Aortic Valve-in-Surgical Aortic Valve (TAV-in-SAV) for Structural Valve Degeneration of Post-Surgical Aortic Valve Replacement (SAVR) With the 3D-Nicks Procedure: A Case Report

Postoperative echocardiography showed mean PG 6 mmHg, EOAi 1.29 cm²/m², stable at three-year follow-up (EOAi 1.16 cm²/m²).

Medicine · Cureus · 4d

Prenatal Diagnosis and Obstetrical Challenges of a Massive Fetal Ascites Affecting One Fetus in a Dichorionic Diamniotic Twin Pregnancy: A Case Report

At 24 weeks, massive fetal ascites with bilateral hydrocele was diagnosed in one male twin. Ultrasound estimated weight at approximately 3.3 kg, but actual birth weight was 2.2 kg; the infant died approximately one hour after birth.

Medicine · Cureus · 4d

Forus secures $150M series C to grow AI-powered medication access platform

If adopted locally, this could streamline prior authorisations and medication access workflows across specialties, reducing delays for patients starting treatment.

General Medicine · Fierce Healthcare · 4d

Hospitals need better SUD care. Team-based approaches are bringing results

Multidisciplinary consult teams improve substance use disorder care in hospitals, aligning with new ASAM guidelines—consider integrating such teams to enhance patient outcomes.

Psychiatry · Fierce Healthcare · 4d

Quel Health launches telehealth platform for addiction treatment using GLP-1s

Offers a new GLP-1-based telehealth option for addiction, potentially expanding access to care.

Medicine · Fierce Healthcare · 4d

AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

FDA priority review for itepekimab could give COPD patients a new biologic option beyond standard inhalers, potentially reducing exacerbations in this hard-to-treat population.

General Medicine · Fierce Biotech · 4d

FDA approves AstraZeneca’s Etcamah, opening ctDNA-guided treatment paradigm in breast cancer

ctDNA-guided use of camizestrant could let you switch endocrine therapy earlier in ER-positive breast cancer when molecular relapse appears before radiologic progression.

Medicine · Fierce Biotech · 4d

Spyre's 3-pronged IBD strategy on track as IL-23 antibody rounds off trio of phase 2 wins

Another anti-IL-23 antibody shows phase 2 efficacy in IBD, widening the biologic armamentarium for patients who fail existing therapies.

Gastroenterology · Fierce Biotech · 4d

Bristol Myers’ pivotal CAR-T multiple myeloma trial hits primary endpoint

A GPRC5D-directed CAR-T reaching its primary endpoint could expand options for relapsed multiple myeloma beyond BCMA-targeted therapy.

Medicine · Fierce Biotech · 4d

Frailty in Cardiorenal Care: A Geriatric Perspective on the 2026 European Society of Cardiology Guidelines

No clinical results reported. Authors propose considering frailty, sarcopenia, cognition, multimorbidity, and function to individualize organ-protective treatment in older adults.

Medicine · Cureus · 4d

Parakeet Health lands major AI partnership with national dermatology group Qualderm

If adopted, agentic AI could help dermatology groups triage referrals and streamline access, potentially reducing wait times for patients needing specialist review.

Medicine · Fierce Healthcare · 4d