Archive

Clarithromycin-Associated Carbamazepine Toxicity Presenting as a Posterior Circulation Stroke Mimic

Serum carbamazepine was 18.6 mg/L and sodium 122 mmol/L, down from a baseline of approximately 130 mmol/L. Symptoms resolved within 48 hours of withholding carbamazepine and correcting hypovolaemia.

Neurology · Cureus · 2d

Stratified Outpatient Management and Radiological Follow-Up After Endovascular Treatment for Unruptured Intracranial Aneurysms

A risk-stratified follow-up schedule after unruptured aneurysm coiling could cut routine imaging visits for stable patients while keeping closer watch on higher-risk anatomy.

Neurology · Cureus · 3d

Age- and Sex-Specific Distribution of Vascular and Behavioural Risk Factors Among Patients With Acute Ischaemic Stroke: A Hospital-Based Study From North India

Dyslipidaemia 56.2%, hypertension 55.4%, diabetes 55.1%. Hypertension and dyslipidaemia rose with age (both p<0.001). RHD was more common in females (15.0% vs 6.1%, p=0.010); combined CAD/RHD 50.3% vs 38.9% (p=0.044).

Neurology · Cureus · 3d

Cerebral Infarction As the Presenting Feature of Janus Kinase 2 (JAK2) V617F-Positive Polycythemia Vera: A Case Report

In young stroke patients without usual risk factors, check a haemoglobin and JAK2 — undiagnosed polycythemia vera is a treatable cause of arterial infarction.

Neurology · Cureus · 4d

Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke.

If late-window thrombectomy still improves outcomes in selected patients with salvageable tissue, your 24-hour treatment cutoff for transfer and imaging decisions needs revisiting.

Neurology · NEJM · 5d

Remibrutinib versus teriflunomide in relapsing multiple sclerosis (REMODEL-1 and REMODEL-2): two randomised, phase 3 trials.

An oral, CNS-penetrant BTK inhibitor with an active comparator against teriflunomide could give your relapsing MS patients a new oral option if the event-driven results hold.

Neurology · Lancet · 5d

Trial of Endovascular Therapy for Mild Stroke with Large-Vessel Occlusion.

Excellent 90-day outcome (mRS 0-1) in 69.4% with endovascular therapy versus 50.0% with medical management alone (odds ratio 2.32; 95% CI 1.41 to 3.81; P<0.001). Symptomatic intracranial haemorrhage occurred in 3 patients per group.

Neurology · NEJM · 5d

Saved by Bell's Palsy: Recurrent Facial Weakness in a Patient With a Cerebellopontine Angle Mass

Recurrent facial palsy with headache or vertigo warrants imaging — a cerebellopontine angle mass can mimic Bell's, and steroids alone would delay its diagnosis.

Neurology · Cureus · 5d

Association of the 2HELPS2B Score With Impaired Recovery of Consciousness and In-Hospital Mortality in Critically Ill Patients: A Multicenter Retrospective Study

A routine EEG risk score may flag sedated ICU patients unlikely to regain consciousness, helping you time neuroprognostication and family discussions earlier.

Neurology · Cureus · 5d

Prognostic Value of High-Sensitivity C-reactive Protein, Interleukin-6, and Lipoprotein(a) in Acute Ischemic Stroke and Recurrent Cerebrovascular Events: A Systematic Review and Meta-Analysis

Elevated biomarkers were associated with poor functional outcome (pooled OR 2.28, 95% CI 1.77-2.80), with substantial heterogeneity (I² = 90.38%). hs-CRP was most consistent (OR 2.29, 95% CI 1.96-2.61); IL-6 did not reach significance (OR 2.30, 95% CI 0.21-4.40).

Neurology · Cureus · 5d

FDA Launches New Program to Advance Neuroscience Medical Product Development

A faster FDA pathway for neuro drugs could shorten the wait before your patients with Parkinson's, epilepsy or Alzheimer's get new options.

Neurology · FDA — Press Announcements · 5d

Assessment of Compliance With the National Institute for Health and Care Excellence Guidance in the Management of Patients Referred Following a First Suspected Seizure: A Retrospective Clinical Audit

Specialist assessment within two weeks in 5 of 53 (9.4%). ECG, recurrence-risk assessment and safety/driving advice documented in 100%. Of 17 needing EEG, 1 (5.9%) had it within 72 hours; mean time to EEG about 12.5 weeks.

Neurology · Cureus · 6d

Bulbar-Predominant Myasthenia Gravis Associated With Muscle-Specific Tyrosine Kinase Antibodies: A Diagnostic Challenge

MuSK antibodies were markedly elevated at 1934 U/mL, confirming MuSK-positive myasthenia gravis with predominant bulbar involvement after AChR antibodies were negative.

Neurology · Cureus · 6d

Vitamin B6 Doses on United States Dietary Supplement Labels Relative to the Tolerable Upper Intake Level: A Census of the National Institutes of Health Dietary Supplement Label Database

Ask patients on high-dose B6 about tingling or numbness — supplement labels often exceed the 100 mg/day UL that causes peripheral neuropathy.

Neurology · Cureus · 7d

Vestibular Epilepsy Presenting With Isolated Recurrent Vertigo and Postictal Headache: A Case Report

Before labelling brief recurrent vertigo as vestibular migraine or BPPV, consider vestibular epilepsy — postictal headache and one-to-two-minute attacks are the clues, and no diagnostic criteria exist yet.

Neurology · Cureus · 7d

Effect of Vestibular Stimulation Exercises on the Level of Consciousness in Patients With Intracerebral Hemorrhage: A Systematic Review

Graded vestibular exercises may be a cheap bedside adjunct to multisensory stimulation for ICH survivors with low consciousness, but this review's evidence is early and needs confirmation before routine use.

Neurology · Cureus · 7d

Fingolimod-Associated Primary Cutaneous Cryptococcosis: A Case Report and Scoping Review With a Focus on Immune Monitoring

On fingolimod, lymphopenia can seed skin cryptococcosis; check absolute lymphocyte counts and biopsy atypical skin lesions rather than assuming benign dermatosis.

Neurology · Cureus · 9d

First Reported Coexistence of Acetylcholine Receptor-Positive Myasthenia Gravis and Genetically Confirmed Spinocerebellar Ataxia Type 6

New weakness or fatigability in a patient with known ataxia may be treatable myasthenia gravis, not progression — consider AChR antibody testing before attributing it to the underlying disease.

Neurology · Cureus · 9d

Early-onset Alzheimer's disease looks very different to late-onset version: Study

In younger patients with depression, dizziness or head injury, keep early-onset Alzheimer's on the differential — the comorbidity pattern differs from late-onset disease.

Neurology · ETHealthworld · 14d

Human-artificial intelligence collaboration for comanaging epilepsy in real time.

Seizure detectors improved precision from patient feedback alone, without expert intervention, in a pseudoprospective simulation; the platform processed sleep, medication, cognition and seizure probability biomarkers.

Neurology · Nature Medicine · 13 Oct

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial.

If this NAD-precursor trial is negative, you can stop fielding patient questions about nicotinamide riboside supplements for early Parkinson disease.

Neurology · JAMA · 8 Oct

Migraine.

Understanding migraine as a multi-system neurovascular disorder supports earlier recognition and use of targeted acute and preventive therapies in your patients.

Neurology · Lancet · 7 Oct

Manganese Deposition Encephalopathy Associated With Prolonged Total Parenteral Nutrition: A Case Report

In patients on prolonged TPN with cholestasis, unexplained parkinsonism or MRI basal ganglia changes should prompt consideration of manganese toxicity from parenteral nutrition.

Neurology · Cureus · 1 Oct

Blueberry Muffin Sign: A Diagnostic Histochemical Clue in Mitochondrial Myopathy

In unexplained bilateral ptosis with ophthalmoplegia, requesting the blueberry muffin histochemical stain on muscle biopsy can confirm mitochondrial myopathy and end a decades-long diagnostic odyssey.

Neurology · Cureus · 30 Sept

Standalone Middle Meningeal Artery Embolization Versus Surgical Evacuation for Nontraumatic Subdural Hematoma: A Propensity-Matched Multicenter Real-World Study

Propensity-matched real-world data suggest standalone MMA embolization may rival surgical evacuation in nontraumatic subdural hematoma, supporting a less invasive option in frail or recurrent cases.

Neurology · Cureus · 30 Sept

CSIR-CCMB study describes how viral infection may pave way for Parkinson's disease

Adds viral infection to the differential for Parkinson's risk, suggesting post-encephalitic patients may warrant closer neurological follow-up.

Neurology · ETHealthworld · 30 Sept

Mechanistic Differences in Adult-Onset and Juvenile-Onset Huntington’s Disease and the Potential Role of Neurodevelopment

Juvenile-onset Huntington's may reflect disrupted circuit maturation rather than pure degeneration, which could mean different timing and targets for intervention in younger patients.

Neurology · Cureus · 30 Sept

Predictors of Postoperative Neurological Outcome After Surgical Evacuation of Traumatic Acute Subdural Hematoma: A Retrospective Cohort Study

Unfavorable outcome occurred in 74 (61.7%) and mortality was 21.7% (26/120). Independent predictors included GCS ≤8 (aOR 4.86), bilateral non-reactive pupils (aOR 4.10), and hypotension (aOR 2.79).

Neurology · Cureus · 30 Sept

A Care-Level-Stratified Algorithm for Neuromodulation in Persistent Spinal Pain Syndrome Type 2: Critical Appraisal of Contemporary Evidence Adapted to Latin American Health Systems

Offers a tiered pathway for post-laminectomy pain, helping you decide when to escalate from medical therapy to spinal cord stimulation in resource-limited settings.

Neurology · Cureus · 29 Sept

Subependymal Giant Cell Astrocytoma Mimicking Recurrent Ependymoma: Imaging Clues to the Diagnosis of Tuberous Sclerosis Complex

In a child with prior ependymoma, a new intraventricular mass may be TSC-related SEGA, not recurrence; imaging clues can spare unnecessary reoperation.

Neurology · Cureus · 29 Sept

Atypical Presentation of a Meningioma Masquerading as Trigeminal Neuralgia: A Diagnostic Challenge in the Emergency Department

Atypical features (prolonged sensory loss, proptosis, diplopia) prompted imaging; CT showed a sclerotic sphenoid lesion, MRI revealed a large en plaque meningioma with orbital extension and optic nerve compression, plus a separate right cerebellopontine angle meningioma.

Neurology · Cureus · 28 Sept

Temporal Trends and Demographic Contributions to Stroke Burden in India, 1990–2023: An Analysis of Global Burden of Disease 2023 Estimates Using Shapley Decomposition and Joinpoint Regression

Incident cases rose from 0.73 million to 1.87 million (155.1%), deaths from 0.42 million to 1.03 million (148.2%), DALYs from 12.41 million to 25.99 million (109.4%). Age-standardised incidence stable; mortality and DALY rates declined.

Neurology · Cureus · 28 Sept

Factors Associated With Recurrence in Patients With Benign Paroxysmal Positional Vertigo Following Canal Repositioning Therapy

Recurrence after repositioning is common, so identifying which BPPV patients need closer follow-up and explicit counselling about relapse risk can reduce repeat ED visits.

Neurology · Cureus · 28 Sept

Atomoxetine for Orthostatic Hypotension in Traumatic and Non-traumatic Spinal Cord Injury: A Case Series From a Neuro-Rehabilitation Setting

When midodrine and fludrocortisone fail in spinal cord injury, atomoxetine may restore blood pressure enough for patients to tolerate rehabilitation sessions.

Neurology · Cureus · 27 Sept

Recurrent Pneumococcal Meningitis Without Cerebrospinal Fluid Pleocytosis and With Fulminant Septic Shock: A Case Report

CSF showed no findings strongly suggestive of meningitis; cultures from blood, urine and CSF grew Streptococcus pneumoniae only the day after death, which occurred on the day of admission

Neurology · Cureus · 26 Sept

Sudden Onset Occipital Headache as a Presenting Feature of Ischaemic Stroke

MRI showed a 3.5 cm acute right occipital infarct; CT was normal. Formal perimetry revealed a left superior homonymous quadrantanopia missed on bedside confrontation.

Neurology · Cureus · 25 Sept

Stroke Mimics in a Tertiary Comprehensive Stroke Center: Implications for Healthcare Provider Education

True strokes were 35.1% (221/630); mimics 64.9% (409/630). Leading mimics: sepsis 5.7%, migraine 4.6%, seizure 3.3%, subdural hematoma 3.3%, hypertensive emergency 3.3%.

Neurology · Cureus · 25 Sept

Why Seizures Break Through: Distinguishing Background Susceptibility From Proximal Precipitants in Patients With Epilepsy

Distinguishing a patient's baseline seizure susceptibility from an immediate trigger like missed doses or sleep loss changes whether you reassure, adjust ASM, or investigate.

Neurology · Cureus · 25 Sept

Radiotherapy versus observation following surgical resection of WHO grade 2 atypical meningioma (ROAM/EORTC-1308): an international, multicentre, open-label, phase 3, randomised controlled trial.

After complete resection of grade 2 meningioma, adjuvant radiotherapy delays recurrence but does not improve overall survival, so timing and patient selection matter more than routine referral.

Neurology · Lancet · 25 Sept

Automated Tractography of Corticospinal and Corticoreticular Projections Originating From Brodmann Area 44 in Patients With Mild Stroke

FA was lower in the lesioned hemisphere for both BA44-origin corticospinal projections (0.484 vs 0.508, P = 0.011) and corticoreticular projections (0.442 vs 0.463, P = 0.049).

Neurology · Cureus · 25 Sept