Archive

Efficacy and safety of mitapivat in adults with transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE-T): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

Transfusion reduction response occurred in 52 (30%) of 171 on mitapivat versus 11 (13%) of 87 on placebo; adjusted difference 18 percentage points (95% CI 8-27; p=0·0003).

General Medicine · Lancet · 8h

A Structured, Auditable Taxonomy for Pharmacist-Identifiable Medication-Related Risk Signals in Routine Admission Data: A Retrospective Medication Safety Audit in a High-Risk Inpatient Cohort

Poor adherence 10 of 17; residual medication discrepancy 5 of 17; self-discontinuation 3 of 17; insulin instruction mismatch 2 of 17; suboptimal blood pressure control 9 of 13; suboptimal glycaemic control 5 of 8.

General Medicine · Cureus · 1d

Mpox (Formerly Known as Monkeypox) in Dermatological Practice: Presentation of a Series of Four Clinical Cases at a Referral Hospital

Presentations ranged from disseminated vesiculopustular eruptions with systemic symptoms to strictly localised painful perianal lesions without prodrome; one case was initially misdiagnosed as herpes.

General Medicine · Cureus · 1d

Unusual Vascular Claudication in a Seronegative Patient: Raynaud's Phenomenon or Atypical Buerger Disease

Proximal vessels were patent with sluggish distal forearm flow and diminutive radial and ulnar arteries at the wrist; hypercoagulable and vasculitis workup was unrevealing and inflammatory markers stayed normal.

General Medicine · Cureus · 1d

Oral Health in Hospitalized Adults: Clinical Outcomes and the Role of Dental Expertise

Strongest evidence is for respiratory outcomes; recent randomised evidence gives preliminary support for structured multicomponent oral care reducing non-ventilator hospital-acquired pneumonia on general wards. Chlorhexidine evidence remains inconsistent.

General Medicine · Cureus · 1d

Disseminated Pulmonary Coccidioidomycosis Presenting as a Wedge-Shaped Necrotic Mass Mimicking Malignancy

CT showed a 7.3 × 5.4 cm wedge-shaped necrotic right middle lobe mass with bilateral nodules; biopsy showed granulomatous inflammation with fungal elements, confirmed by serology and BAL PCR

General Medicine · Cureus · 1d

STAT+: Can AI save rural health care?

Federal bets on AI for rural care may shape what tools reach your understaffed district hospital, though none are proven yet.

General Medicine · STAT News — Health Tech · 2d

Clinical and Radiographic Success of Pulpotomy in Permanent Teeth With Irreversible Pulpitis: A Systematic Review

Across 16 included studies, pulpotomy consistently gave favourable clinical and radiographic success in permanent teeth with irreversible pulpitis, especially with MTA, Biodentine, CEM and other bioceramics.

General Medicine · Cureus · 2d

Improving Antibiotic Stewardship Through a Retrospective Study of the Diagnostic Value of Nasal Methicillin-Resistant Staphylococcus aureus Polymerase Chain Reaction for Pneumonia in Intensive Care Unit Settings

Nasal MRSA PCR sensitivity for MRSA in lower respiratory cultures was 90% (18/20); positive predictive value was only 60% (18/30).

General Medicine · Cureus · 2d

At CTA event, federal officials outline AI ambitions as clinicians debate risks

US federal payment policy increasingly shapes which AI tools reach clinics, so adoption decisions may soon follow CMS priorities rather than local evidence alone.

General Medicine · Fierce Healthcare · 2d

Trump officials say AI will help save rural health care. Some leaders in the field don’t believe it

If you work in a low-resource setting, AI tools are being offered as cover for Medicaid cuts that will close rural hospitals and clinics.

General Medicine · STAT News — Health Tech · 2d

Severe Colchicine Toxicity After Ingestion of a Dose Below Traditionally Reported Lethal Levels: A Case Report

Ingestion of 20 mg (0.26 mg/kg) caused hyperthermia, electrolyte derangement, rhabdomyolysis, coagulopathy and bone marrow suppression; the patient recovered fully with supportive care, GCSF and platelet transfusion.

General Medicine · Cureus · 2d

Characterization and Antimicrobial Susceptibility Patterns of Clinically Significant Non-fermenting Gram-Negative Bacilli Isolated From Clinical Specimens

Pseudomonas aeruginosa 61 (48.03%), Acinetobacter baumannii 53 (41.73%), Stenotrophomonas maltophilia 13 (10.24%). A. baumannii and P. aeruginosa were highly carbapenem-resistant; S. maltophilia remained susceptible to antibiotics tested.

General Medicine · Cureus · 2d

Front-of-pack labels: Food Inc bats for per-serving benchmark in SC, not FSSAI’s ‘per 100 gm’ plan

Per-serving labels understate salt, sugar and fat in foods patients eat in larger amounts, so the benchmark chosen decides how useful your dietary counselling is.

General Medicine · ETHealthworld · 2d

Outbreak of Severe Methemoglobinemia during Maritime Migration.

Median methemoglobin 44.6% (IQR 32.0–55.7); 43% had levels ≥50%. Methylene blue used in 90%. Hemolytic anemia in 38 patients; 2 died. N-methylaniline or metabolites found in 37 of 39 tested patients (95%).

General Medicine · NEJM · 2d

Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health.

Self-reported depression and anxiety prevalence exceeded national estimates; concordance with UK Biobank was r=0.78 for disease prevalence and r=0.80 for clinical correlates. Lung cancer rates were lower than national data.

General Medicine · Nature Medicine · 2d

Rheumatoid Arthritis in Adults: A Review.

About 40% of newly diagnosed patients achieve CDAI remission within 6 months on first-line DMARDs; adding biological DMARDs or JAK inhibitors increases remission or low disease activity to approximately 80%.

General Medicine · JAMA · 2d

A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial.

No treatment-related serious adverse events, deaths, or grade ≥3 CRS/neurotoxicity; CRS mostly grade 1 (91.6%, 11/12). Exploratory: 80% (8/10) achieved LLDAS and 60% (6/10) DORIS at 12 months.

General Medicine · Nature Medicine · 2d

STAT+: Can AI fix the emergency room?

AI won't solve ER overcrowding or staffing shortages; focus on systemic fixes, not tech hype.

General Medicine · STAT News — Health Tech · 3d

Increases in healthcare spending the largest driver behind premium growth: Yale study

Understanding that spending—not insurer profit—drives premiums helps you advocate for cost-effective care and explain rising patient costs.

General Medicine · Fierce Healthcare · 3d

With elderly population set to double by 2050, govt looks to step up healthcare, caregiving services

Expect more geriatric-focused services and referrals; plan for rising multimorbidity and caregiver support in your practice.

General Medicine · ETHealthworld · 3d

Lenacapavir-Based Salvage Therapy in Heavily Treatment-Experienced Multidrug-Resistant HIV-1: A Case Report From the United Arab Emirates

After virologic rebound in 2023 and failure of salvage regimens, lenacapavir with BIC/FTC/TAF in 2024 produced a rapid undetectable viral load, with suppression maintained to date.

General Medicine · Cureus · 3d

Distribution of gyrA, rrs, and eis Gene Mutations Associated With Second-Line Drug Resistance Among Multidrug-Resistant Mycobacterium tuberculosis Isolates

FQ resistance in 30 (35.3%) isolates, SLID resistance in 7 (8.2%). Commonest FQ mutation gyrA D94G (53.3%), then A90V (20.0%), D94N/Y (16.7%). rrs A1401G in 28.6% and G1484T in 14.3% of SLID-resistant isolates; no eis mutations.

General Medicine · Cureus · 3d

Differences Between Oncological and Non-oncological Patients Referred to an In-Hospital Palliative Care Support Team: A Retrospective Cohort Study in Northern Portugal

In-hospital mortality was 48.9% (44/90) in non-oncological versus 19.8% (21/106) in oncological patients; transfer to a specialist palliative care unit was 16.7% (15/90) versus 42.5% (45/106).

General Medicine · Cureus · 3d

STAT+: Can AI fix health care? In the chaos of emergency rooms, the technology comes up short

AI tools underdeliver in real ED chaos; don't rely on them for critical triage decisions yet.

General Medicine · STAT News — Health Tech · 3d

Beeline flies into phase 3 as oral lupus drug soars past placebo

An oral option for lupus could reduce injection burden; watch for phase 3 efficacy and safety data before changing practice.

General Medicine · Fierce Biotech · 3d

ICMR-NIV study detects insecticide resistance in dengue vector mosquitoes in parts of Pune

If you manage dengue cases, expect control failures in Pune; consider alternative vector control and patient counselling on prevention.

General Medicine · ETHealthworld · 3d

Forus secures $150M series C to grow AI-powered medication access platform

If adopted locally, this could streamline prior authorisations and medication access workflows across specialties, reducing delays for patients starting treatment.

General Medicine · Fierce Healthcare · 4d

AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

FDA priority review for itepekimab could give COPD patients a new biologic option beyond standard inhalers, potentially reducing exacerbations in this hard-to-treat population.

General Medicine · Fierce Biotech · 4d

Wildfire smoke and health: current evidence, mechanisms, and future challenges.

No primary outcome or effect estimate reported. Authors state key gaps persist: long-term health effects, interactions with pre-existing conditions, and health disparities.

General Medicine · Lancet · 4d

Effect of Delayed Presentation on the Prognosis of Snakebite Victims at a Tertiary Care Hospital: The Golden Hour Matters

Mortality was 75% (3/4) in the 18-24-hour group versus 7.1% (1/14) in the zero-to-six-hour group. Recovery was highest in the zero-to-six-hour group at 71.4%.

General Medicine · Cureus · 5d

Imaging Pulmonary Embolism in the Era of Subsegmental Clots: What the Internist Needs to Know About Overdiagnosis, Anticoagulation, and Follow-Up

Short-term recurrence rates in SSPE are low and do not differ significantly from proximal PE. No randomized controlled trial data guide anticoagulation; selected low-risk patients may be safely observed.

General Medicine · Cureus · 5d

When an Extra X Means Extra Risk: Venous Thromboembolism in Klinefelter Syndrome

Massive bilateral pulmonary embolism with concurrent DVT occurred despite normal hematocrit (48.8% at admission, normal over 13 months), negative thrombophilia panel, implicating KS-intrinsic hypercoagulability.

General Medicine · Cureus · 5d

Acupuncture-Induced Pneumothorax Following Thoracic Acupuncture in a Patient With Ehlers-Danlos Syndrome: A Case Report

Left apical pneumothorax (2.8 cm) developed; aspiration removed 450 mL air, but repeat imaging showed minimal reduction; resolved spontaneously within 24 hours.

General Medicine · Cureus · 5d

IIT Madras patents polymer tech that disintegrates bacteria on surfaces without harming human cells

Offers a non-antibiotic surface coating to curb hospital-acquired infections and superbug spread, potentially reducing reliance on conventional antimicrobials.

General Medicine · ETHealthworld · 5d

FSSAI to tighten scrutiny, weighs central ban on non-dairy paneer

A central ban would curb adulterated analogue paneer in your patients' diets, reducing risks from undeclared fats and additives.

General Medicine · ETHealthworld · 6d

Delhi HC backs NMC: Fragmented foreign medical degrees not enough for FMGE eligibility

If you supervise or train FMGE aspirants, this ruling tightens verification—fragmented foreign training won't qualify, affecting recruitment and credential checks.

General Medicine · ETHealthworld · 7d

Medulance Raises ₹24 Cr To Expand Emergency Response Network

Expands ambulance availability and response times for your patients in emergencies, potentially improving critical care access across cities.

General Medicine · Inc42 · 8d

STAT+: OpenEvidence launches new family of AI models

If these models improve clinical evidence retrieval, you may get faster, more accurate answers at the point of care—worth trialing in your workflow.

General Medicine · STAT News — Health Tech · 9d

Leading medical groups release flu, COVID vaccine recommendations as CDC guidance lags

With CDC silent, these recommendations give you a clear vaccination schedule for flu and COVID to follow this season.

General Medicine · Fierce Healthcare · 10d