Archive

Ianalumab for the Treatment of Patients with Sjögren's Disease.

Sjögren's has no approved targeted therapy; a B-cell depleting BAFF-receptor antibody could finally give you a disease-modifying option beyond symptomatic care.

General Medicine · NEJM · 6d

Helicobacter pylori Infection - Advances, Challenges, and the Road Ahead.

Eradicating H. pylori remains the main lever against gastric cancer, yet no vaccine exists and resistance is eroding standard regimens — test-and-treat strategy still needs refining.

Gastroenterology · NEJM · 6d

Pregnancy Outcomes After Living Kidney Donation.

Gestational hypertension, preeclampsia or eclampsia occurred in 11.9% of donor pregnancies versus 8.3% in nondonors (risk ratio 1.51; 95% CI 1.10-2.08). Small for gestational age: 13.8% versus 7.9% (risk ratio 1.86; 95% CI 1.37-2.52).

Obstetrics & Gynaecology · JAMA · 6d

Ischemic Stroke in Children With Sickle Cell Disease: A Report of Three Cases and a Review of the Literature

All three presented with acute focal deficits (hemiparesis, facial paralysis); imaging confirmed cerebral ischemia, with Moyamoya syndrome on MRI in one. One had recurrent strokes and one died of acute chest syndrome in hospital.

Paediatrics · Cureus · 6d

Pathogenic Synergy in Intestinal Obstruction: Incomplete Malrotation, Cholecystoduodenal Fistula, and Gallstone Ileus

Laparotomy confirmed incomplete malrotation with an incomplete obstructive Ladd's band and a cholecystoduodenal fistula causing gallstone ileus. Ladd's band section, enterolithotomy and appendectomy were done; bowel transit recovered on day 3.

General Surgery · Cureus · 6d

Assessment of Compliance With the National Institute for Health and Care Excellence Guidance in the Management of Patients Referred Following a First Suspected Seizure: A Retrospective Clinical Audit

Specialist assessment within two weeks in 5 of 53 (9.4%). ECG, recurrence-risk assessment and safety/driving advice documented in 100%. Of 17 needing EEG, 1 (5.9%) had it within 72 hours; mean time to EEG about 12.5 weeks.

Neurology · Cureus · 6d

Asymmetric Outcomes in Bilateral Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis: A Case Report

Bilateral MOG-ON can recover asymmetrically despite steroids, so counsel patients cautiously and consider MOG antibody testing early in severe bilateral optic neuritis.

Ophthalmology · Cureus · 6d

An Unusual Thoracic Presentation of Multiple Myeloma: Rib-Based Paraskeletal Plasmacytoma Mimicking a Lung Mass

Biopsy showed CD38-positive kappa-restricted plasma cells; marrow had 30% clonal plasma cells on trephine immunohistochemistry (15.9% by flow cytometry), with severe anemia and multifocal lytic disease. He died 67 days after admission.

Oncology · Cureus · 6d

STAT+: What’s the deal with Isomorphic Labs?

Isomorphic's valuation signals investor bets on AI-designed drugs; watch whether its pipeline delivers candidates that reach trials you might prescribe.

Medicine · STAT News — Health Tech · 6d

Doximity adds UpToDate to Ask in push to become doctors’ go-to AI platform

If your hospital or app stack uses Doximity Ask, answers will now be grounded in UpToDate content rather than generic model output — worth knowing before you trust it at the bedside.

General Medicine · Fierce Healthcare · 6d

Bulbar-Predominant Myasthenia Gravis Associated With Muscle-Specific Tyrosine Kinase Antibodies: A Diagnostic Challenge

MuSK antibodies were markedly elevated at 1934 U/mL, confirming MuSK-positive myasthenia gravis with predominant bulbar involvement after AChR antibodies were negative.

Neurology · Cureus · 6d

Energy and Protein Intake Deficits in the Immediate Postpartum Period: A Prospective Observational Study

Your postpartum patients are likely leaving hospital in significant calorie and protein deficit — quantify intake and address cultural food restrictions before discharge, not at the six-week visit.

Obstetrics & Gynaecology · Cureus · 6d

Laparoscopic Endometriosis Phenotypes and Preoperative Non-suspicion of Endometriosis in Women With Superficial Disease: A Retrospective Study in Kinshasa

Among 135 women with superficial peritoneal endometriosis, 83 (61.5%; 95% CI, 53.1%-69.3%) had no documented preoperative suspicion of endometriosis; in isolated superficial disease this was 46/56 (82.1%).

Obstetrics & Gynaecology · Cureus · 6d

Vogt-Koyanagi-Harada Syndrome Masquerading as Isolated Headache Despite a Reassuring Workup: A Case Report

Bilateral multifocal exudative retinal detachments, choroidal folds and disc edema with active choroidal inflammation on angiography; high-dose corticosteroids gave only transient improvement with recurrence on taper; adalimumab helped but was stopped for insurance reasons; mycophenolate maintained improvement through six months

Ophthalmology · Cureus · 6d

Navigating Outcomes and Tailored Treatment Choices in a Cesarean Scar Ectopic Pregnancy: Insights From Five Cases in a Resource-Limited Facility

CSP is rising with cesarean rates; five cases show how to individualise methotrexate, surgery or expectant care when you have limited resources and no protocol.

Obstetrics & Gynaecology · Cureus · 6d

Initial Outcomes of GammaTile Brachytherapy From a Single Institution: A Case Series

Implanted at resection, it delivers most radiation before adjuvant therapy would normally start — relevant if you refer brain tumour patients for post-op radiotherapy.

Oncology · Cureus · 6d

Time From Injury to First Antibiotic Administration and Deep Infection Risk in Open Fractures: A Systematic Review and Meta-Analysis

The one-hour antibiotic rule for open fractures rests on weaker evidence than you may assume; this meta-analysis separates the timing effect from confounders like injury severity.

Orthopaedics · Cureus · 6d

Persistent Sleepiness After Effective Positive Airway Pressure Therapy Deserves Independent Clinical Evaluation

When a patient on PAP still reports daytime sleepiness despite good adherence and control, work it up separately rather than escalating pressure or dismissing it as treated OSA.

General Medicine · Cureus · 6d

Subclinical Hypothyroidism: Who Should Be Treated and Who Can Be Observed?

Most SCH is transient and TSH under 10 rarely needs levothyroxine; repeat TSH in 6-8 weeks before prescribing, and treat if pregnant, symptomatic or TSH rising.

Endocrinology · Cureus · 6d

Technique of Intravenous Regional Block for Complex Regional Pain Syndrome Using Methylprednisolone, Lidocaine, and Labetalol

Gives you a reproducible Bier-block protocol for CRPS when you want a low-risk option before escalating to sympathetic blocks or neuromodulation.

Anaesthesiology · Cureus · 6d

HHS launches national kidney care plan focused on disease prevention, dialysis care and reforming the transplant system

A US policy blueprint, not Indian guidance — but its prevention-first framing and transplant reform signal where nephrology capacity debates are heading.

General Medicine · Fierce Healthcare · 6d

Researchers identify subtype of depression linked to body's internal clock

A circadian-linked depression subtype in 10,000+ patients suggests sleep and clock-based symptoms could guide stratification and treatment choice in your depressed patients.

Psychiatry · ETHealthworld · 6d

Tailoring the Extent of Therapeutic Lateral Neck Dissection in Papillary Thyroid Carcinoma With Lateral Cervical Lymph Node Metastases: A Systematic Review

Level-specific metastasis rates and morbidity data can help you spare levels IIb, Va and Vb in selected PTC patients without sacrificing oncological control.

General Surgery · Cureus · 6d

Baba nabs $40M series A, backed by FirstMark Capital and CVS Health Ventures, for AI-powered Medicare patient navigation

If your Medicare patients get AI navigation support through their plan, expect fewer missed referrals and more care-coordination queries landing in your clinic.

General Medicine · Fierce Healthcare · 6d

Efficacy and Safety of Automated Insulin Delivery Systems in Children and Adolescents With Type 1 Diabetes: A Systematic Review of Randomized Controlled Trials

Time in range improved by roughly 7 to 12 percentage points across trials; one showed 11 points (95% CI 7-14) and another 8.7 points (95% CI 7.4-9.9) with a 0.4-point HbA1c fall. Hypoglycaemia did not consistently increase.

Endocrinology · Cureus · 6d

Building Demand for Human Papillomavirus (HPV) Vaccination in India: A Review of the Behavioural and Social Drivers of Parental and Community Acceptance

With only 80 lakh of 1.2 crore eligible girls vaccinated, your counselling of parents on HPV vaccine safety and cancer prevention is the main lever on uptake.

Obstetrics & Gynaecology · Cureus · 6d

Fallopian Tube Entrapment as a Cause of Catheter Dysfunction in Peritoneal Dialysis: An Unusual Case

When a PD catheter fails in a young woman, remember pelvic structures can entrap it — laparoscopy, not just flushing, may be needed.

Obstetrics & Gynaecology · Cureus · 6d

As weight-loss drug users turn to dietary supplements, doctors, regulators raise flags

Ask GLP-1 patients about supplement use — unregulated products marketed for weight loss carry interaction and contamination risks your prescription review won't catch.

Endocrinology · ETHealthworld · 6d

A Case of Legionella Disease Mimicking Dermatomyositis

Legionella can present with rash and myalgia that mimic dermatomyositis, so consider it in severe pneumonia with skin findings before starting steroids.

General Medicine · Cureus · 6d

Evaluation of Catheter-Associated Urinary Tract Infection Rates in Surgical and Medical Intensive Care Units at a Tertiary Care Center: A Surveillance Study From North India

Local CAUTI rates give you a benchmark to audit your own ICU catheter days and justify early removal protocols.

General Medicine · Cureus · 6d

A Case Report of Lichen Amyloidosis

Lichen amyloidosis mimics common chronic dermatoses; keep it in the differential for persistent pruritic papules so diagnosis isn't delayed by years of eczema treatment.

General Medicine · Cureus · 6d

Efficacy and Safety of Once-Weekly Subcutaneous Semaglutide in Adolescents With Obesity: A Retrospective Study

Mean reductions at 32 weeks: body weight -15.20 kg (17.2%), BMI -6.70 kg/m² (19.4%), BMI-SDS -1.08, waist circumference -10.71 cm, systolic BP -8.30 mmHg; glycaemic and lipid parameters also improved (all p < 0.001). No adverse events documented.

Endocrinology · Cureus · 6d

Strategic Optimization of Nurse-Patient Ratios Across Units and Shifts in a Teaching Hospital

Fixed ward-wide staffing ratios ignore shift and acuity swings; unit- and shift-specific ratios may cut the understaffed shifts where your patients come to harm.

General Medicine · Cureus · 6d

Paraneoplastic Hypertrophic Osteoarthropathy in the Setting of Dual Primary Malignancies: Follicular Thyroid Carcinoma and Metastatic Colon Adenocarcinoma

Clubbing and painful periostitis can be the presenting sign of an occult second malignancy; consider paraneoplastic HOA when joint pain accompanies cancer.

Oncology · Cureus · 7d

Impact of Stone Size on the Technical Success of Endoscopic Retrograde Cholangiopancreatography for Common Bile Duct Stone Extraction in Older Adults: A Single-Center Retrospective Study at a Secondary Care Hospital in Mexico

Technical success was 78.0% overall (32 of 41). Success was 89.7% with stones under 15 mm versus 50.0% with stones 15 mm or larger (p = 0.011); odds of failure OR 8.67 (95% CI 1.67-44.94).

Gastroenterology · Cureus · 7d

Early vs. Interval Cholecystectomy for Acute Calculous Cholecystitis: A Prospective Observational Study in an Indian Adult Population

Conversion to open surgery occurred in 20/38 (52.6%) early versus 14/62 (22.6%) interval cases (OR 3.81, 95% CI 1.59-9.11; p=0.002). Bile duct injury was 13.2% versus 6.5%, not significant. Median total stay was six versus seven days.

General Surgery · Cureus · 7d

Awareness and Utilization of AI-Powered Smile Design Software Among Dental Students: A Pilot Study

Indian dental students report low awareness and use of AI smile-design tools, so expect new graduates to need training before these planners enter routine aesthetic practice.

Medicine · Cureus · 7d

Histopathological Spectrum of Malignancies in the Female Genital Tract in a Tertiary Care Hospital in Central India

Local histopathology data on genital tract cancers helps you anticipate which tumour types and ages dominate your referrals where registry coverage is thin.

Obstetrics & Gynaecology · Cureus · 7d

The Integrated Operation Theatre Spine Suite in the Robotic Era: From a Collection of Technologies to a Surgical Ecosystem

Proposes a plan-visualize-navigate-execute-monitor-verify sequence for complex spine cases, so you can judge whether your OT's imaging and robotics actually work as one workflow.

Orthopaedics · Cureus · 7d

Inequality is major factor in impact of non-communicable diseases: WHO

Your NCD patients' outcomes depend as much on their income and locality as on the drug you prescribe, so screening and follow-up need to target the most disadvantaged groups.

General Medicine · ETHealthworld · 7d