Archive

First Indian genome-wide study sheds light on genetic risk of endometriosis

Confirms Indian women share known endometriosis risk loci plus population-specific signals, supporting earlier genetic suspicion in unexplained pelvic pain and infertility.

Obstetrics & Gynaecology · ETHealthworld · 10 Sept

Front-of-pack labels: Food Inc bats for per-serving benchmark in SC, not FSSAI’s ‘per 100 gm’ plan

Per-serving labels understate salt, sugar and fat in foods patients eat in larger amounts, so the benchmark chosen decides how useful your dietary counselling is.

General Medicine · ETHealthworld · 10 Sept

Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.

At 90 days, 69.7% on loberamisal reached mRS 0-1 versus 56.3% on placebo (risk difference 13.28%, 95% CI 7.24%-19.32%)

Neurology · JAMA · 10 Sept

Outbreak of Severe Methemoglobinemia during Maritime Migration.

Median methemoglobin 44.6% (IQR 32.0–55.7); 43% had levels ≥50%. Methylene blue used in 90%. Hemolytic anemia in 38 patients; 2 died. N-methylaniline or metabolites found in 37 of 39 tested patients (95%).

General Medicine · NEJM · 10 Sept

Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health.

Self-reported depression and anxiety prevalence exceeded national estimates; concordance with UK Biobank was r=0.78 for disease prevalence and r=0.80 for clinical correlates. Lung cancer rates were lower than national data.

General Medicine · Nature Medicine · 10 Sept

Rheumatoid Arthritis in Adults: A Review.

About 40% of newly diagnosed patients achieve CDAI remission within 6 months on first-line DMARDs; adding biological DMARDs or JAK inhibitors increases remission or low disease activity to approximately 80%.

General Medicine · JAMA · 10 Sept

COVID-19 vaccination around immune checkpoint inhibitor start and survival in a nationwide cohort of patients with cancer.

Pre-ICI mRNA vaccination: HR 0.90 (95% CI 0.87-0.94) at 1-3 months, 0.96 (0.93-1.00) at 6 months, no association after 12 months. Post-ICI: HR 0.84 (0.80-0.88) at 3 months.

Oncology · Nature Medicine · 10 Sept

Advances in the diagnosis and management of skin and soft tissue infections.

No primary outcome data. Non-purulent SSTI is typically streptococcal; purulent SSTI is typically Staphylococcus aureus. Laboratory testing is of limited use in most patients.

General Medicine · BMJ · 10 Sept

Computable longitudinal patient journeys from structured and unstructured EHR data.

Physician adjudication confirmed high accuracy against a blinded expert reference standard, with high expert physician inter-reviewer agreement. The framework identified large numbers of patients initiating GLP-1 RAs and modelled longitudinal changes in weight and HbA1c.

General Medicine · Nature Medicine · 10 Sept

A clinically-oriented foundation model for intraoperative pathology.

In over 3,000 prospective patients, CRISP informed surgical decisions in 92.6% of cases; human-AI collaboration cut diagnostic workload by 35%, avoided 105 ancillary tests, and detected micrometastases with 87.5% accuracy.

General Surgery · Nature Medicine · 10 Sept

Exploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study.

24 cascades (37%) met all three criteria. Highest incidence: iron supplement to laxative 11.9% (95% CI 11.7% to 12.1%), statin to pain reliever 10.9% (10.7% to 11%).

General Medicine · BMJ · 10 Sept

Treatment Decisions in Multiple Myeloma.

Quadruplet induction is now standard in newly diagnosed myeloma and the role of autologous transplantation is being reevaluated; in relapse, BCMA-directed CAR T cells, bispecific antibodies and antibody-drug conjugates are sequenced by T-cell fitness and multiantigen targeting.

Oncology · NEJM · 10 Sept

A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial.

No treatment-related serious adverse events, deaths, or grade ≥3 CRS/neurotoxicity; CRS mostly grade 1 (91.6%, 11/12). Exploratory: 80% (8/10) achieved LLDAS and 60% (6/10) DORIS at 12 months.

General Medicine · Nature Medicine · 10 Sept

Prevalence of and factors associated with gestational diabetes mellitus and diabetes in pregnancy in Bangladesh: a facility-based cross-sectional study (2019-2020).

GDM prevalence was 19.4% and diabetes in pregnancy 8.1%. Urban versus rural: GDM 24.4% vs 12.6%, DIP 11.0% vs 4.1%. GCT discrimination was good (AUC 0.83 for GDM, 0.89 for DIP).

Obstetrics & Gynaecology · Lancet regional health. Southeast Asia · 10 Sept

STAT+: U.K. unveils recommendations for regulating AI in medicine

Signals future approval and liability standards for AI tools you may adopt; watch for alignment with your local regulators.

Medicine · STAT News — Health Tech · 10 Sept

Cardiovascular Comorbidities in Knee Osteoarthritis: Prevalence, Functional association, and Therapeutic Consequences

98 (62.0%) had at least one cardiovascular comorbidity. Those affected had worse Lequesne scores (12.4 ± 4.2 vs. 10.3 ± 4.6; p = 0.004) and lower systemic NSAID use (31.6% vs. 55.0%; p = 0.01).

Orthopaedics · Cureus · 10 Sept

Surgical Deconstruction of Recurrent Basilar Apex Aneurysms Refractory to Endovascular Treatment

Both patients achieved safe, immediate and durable aneurysm disconnection; angiographic posterior communicating artery presence and an intraoperative perforator-free zone were key to the approach

Neurology · Cureus · 9 Sept

STAT+: ARPA-H to invest $62 million to develop FDA-authorized AI to help treat heart failure

AI-guided heart failure therapy could soon be FDA-authorized, potentially changing how you titrate medications and monitor patients.

Cardiology · STAT News — Health Tech · 9 Sept

STAT+: Can AI fix the emergency room?

AI won't solve ER overcrowding or staffing shortages; focus on systemic fixes, not tech hype.

General Medicine · STAT News — Health Tech · 9 Sept

Analgesic Efficacy of Celecoxib Versus Ibuprofen After Third Molar Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

No significant difference at 4-8 or 12-16 hours. At 24 hours, celecoxib had lower VAS scores (SMD −0.35; 95% CI −0.61 to −0.08; p=0.01), but TOPAR/TOTPAR showed no difference (SMD 0.36; 95% CI −0.00 to 0.73; p=0.05).

General Surgery · Cureus · 9 Sept

Interra Health now supports CMS’ GLP-1 Bridge Program

If you prescribe GLP-1s, this platform flags patients who may qualify for the CMS Bridge Program, easing access and cost barriers.

Endocrinology · Fierce Healthcare · 9 Sept

nPhase launches AI clinical data management platform to soup up sponsor trial design

If your site runs sponsored trials, AI-driven data management may shorten query resolution and speed the path from enrolment to published result.

Medicine · Fierce Biotech · 9 Sept

Increases in healthcare spending the largest driver behind premium growth: Yale study

Understanding that spending—not insurer profit—drives premiums helps you advocate for cost-effective care and explain rising patient costs.

General Medicine · Fierce Healthcare · 9 Sept

Extended Thromboprophylaxis With Rivaroxaban, Aspirin, or No Prophylaxis After Reverse Total Shoulder Arthroplasty: Practice Patterns and 90-Day Complications in a Single-Center Retrospective Cohort Study

Symptomatic PE: 1/28 (3.6%) no prophylaxis, 1/17 (5.9%) aspirin, 0/23 (0%) rivaroxaban; p=0.717, no pairwise comparison significant. No deep vein thrombosis occurred.

Orthopaedics · Cureus · 9 Sept

With elderly population set to double by 2050, govt looks to step up healthcare, caregiving services

Expect more geriatric-focused services and referrals; plan for rising multimorbidity and caregiver support in your practice.

General Medicine · ETHealthworld · 9 Sept

Lenacapavir-Based Salvage Therapy in Heavily Treatment-Experienced Multidrug-Resistant HIV-1: A Case Report From the United Arab Emirates

After virologic rebound in 2023 and failure of salvage regimens, lenacapavir with BIC/FTC/TAF in 2024 produced a rapid undetectable viral load, with suppression maintained to date.

General Medicine · Cureus · 9 Sept

Distribution of gyrA, rrs, and eis Gene Mutations Associated With Second-Line Drug Resistance Among Multidrug-Resistant Mycobacterium tuberculosis Isolates

FQ resistance in 30 (35.3%) isolates, SLID resistance in 7 (8.2%). Commonest FQ mutation gyrA D94G (53.3%), then A90V (20.0%), D94N/Y (16.7%). rrs A1401G in 28.6% and G1484T in 14.3% of SLID-resistant isolates; no eis mutations.

General Medicine · Cureus · 9 Sept

Comparison of Sequential Organ Failure Assessment (SOFA), Quick Sequential Organ Failure Assessment (qSOFA), Obstetrically Modified SOFA, and Obstetrically Modified qSOFA Scores for Predicting Maternal Outcomes in High-Risk Obstetric Patients

15 maternal deaths. SOFA AUC 0.97 (95% CI 0.94-0.99) at cutoff ≥10; omSOFA 0.93 (0.89-0.97) at ≥9; qSOFA 0.76 (0.68-0.84); omqSOFA 0.79 (0.71-0.87).

Obstetrics & Gynaecology · Cureus · 9 Sept

Intrawound Vancomycin Powder Reduces Deep Surgical Site Infection in Tibial Plateau and Pilon Fractures: A Systematic Review and Meta-Analysis

Deep SSI fell with vancomycin powder (OR 0.53; 95% CI 0.35-0.80; p = 0.002; I² = 0%), infection rate 4.9% versus 9.7%. Gram-positive deep infections fell (OR 0.32; 95% CI 0.14-0.73; p = 0.007). Superficial SSI unchanged (OR 1.17; p = 0.66).

Orthopaedics · Cureus · 9 Sept

Tyra rolls toward pivotal bladder cancer study even as midphase data deflates stock

Dabogratinib's complete response rate missed analyst targets, so watch for confirmatory data before considering it for FGFR-altered bladder cancer patients.

Oncology · Fierce Biotech · 9 Sept

Differences Between Oncological and Non-oncological Patients Referred to an In-Hospital Palliative Care Support Team: A Retrospective Cohort Study in Northern Portugal

In-hospital mortality was 48.9% (44/90) in non-oncological versus 19.8% (21/106) in oncological patients; transfer to a specialist palliative care unit was 16.7% (15/90) versus 42.5% (45/106).

General Medicine · Cureus · 9 Sept

Kura creates Lilly-backed spinout armed with $50M to advance next-gen diabetes therapy

A new Lilly-backed spinout with $50M may bring a next-gen diabetes option—watch for efficacy or safety gains over current therapies.

Endocrinology · Fierce Biotech · 9 Sept

Opinion: Autonomous AI will beat AI-assisted physicians at some medical tasks by 2030

Anticipate AI outperforming you in diagnosis and planning by 2030; prepare to shift your role toward oversight and complex cases.

Medicine · STAT News — Health Tech · 9 Sept

Opinion: AMA CEO: AI won’t replace doctors — it will work alongside them

AMA’s stance signals AI as a clinical ally, not replacement—shaping how Indian regulators and hospitals may adopt AI tools.

Medicine · STAT News — Health Tech · 9 Sept

STAT+: Can AI fix health care? In the chaos of emergency rooms, the technology comes up short

AI tools underdeliver in real ED chaos; don't rely on them for critical triage decisions yet.

General Medicine · STAT News — Health Tech · 9 Sept

Abbott garners FDA nod for its TactiFlex catheter to treat AFib

A new ablation catheter option for AFib may improve procedural flexibility and outcomes in your electrophysiology cases.

Cardiology · Fierce Biotech · 9 Sept

Characterization of Delirium in an Intensive Care Unit: Real-World Data Based on the Application of the Confusion Assessment Method

66 of 788 admissions (8.4%) had a positive CAM-ICU. Delirium patients were older (median 71 vs 68 years), had longer ICU stay (median 8 vs 3 days), and higher invasive ventilation rate (62.5% vs 40.3%).

Anaesthesiology · Cureus · 9 Sept

Vicarious Contrast Medium Excretion Mimicking Acute Hemorrhage: Don't Call the Interventional Radiologist!

Repeat CT showed hyperdense material in gallbladder and small bowel suggesting recurrent bleeding; unenhanced images showed the material preceded the second contrast dose and was unchanged after it, confirming benign vicarious excretion.

Radiology · Cureus · 9 Sept

A Rare Event Causing Blindness in an Unrecognised Pregnancy: A Case Report

Visual acuity was 2/60 right and 3/60 left at presentation, with optic disc swelling, macular star, Purtscher flecken and serous macular detachment; acuity remained poor at two months despite high-dose IV methylprednisolone and oral prednisolone taper.

Medicine · Cureus · 9 Sept

Beeline flies into phase 3 as oral lupus drug soars past placebo

An oral option for lupus could reduce injection burden; watch for phase 3 efficacy and safety data before changing practice.

General Medicine · Fierce Biotech · 9 Sept