Archive

A Structured, Auditable Taxonomy for Pharmacist-Identifiable Medication-Related Risk Signals in Routine Admission Data: A Retrospective Medication Safety Audit in a High-Risk Inpatient Cohort

Poor adherence 10 of 17; residual medication discrepancy 5 of 17; self-discontinuation 3 of 17; insulin instruction mismatch 2 of 17; suboptimal blood pressure control 9 of 13; suboptimal glycaemic control 5 of 8.

General Medicine · Cureus · 11 Sept

Reverse Total Shoulder Arthroplasty in a 25-Year-Old Woman With Seropositive Rheumatoid Arthritis After Prior Age-Based Surgical Deferral

At two years, ASES score 80/100 (pain 3/10, ADL 27/30) and SANE 95%, with no instability, infection, or mechanical failure.

Orthopaedics · Cureus · 11 Sept

Pediatric Headache: A Practical Approach to Clinical Diagnosis and Management

No numerical results reported. Diagnosis rests on structured history, disability assessment and examination; red flags prompt risk stratification rather than reflexive neuroimaging

Paediatrics · Cureus · 11 Sept

Mpox (Formerly Known as Monkeypox) in Dermatological Practice: Presentation of a Series of Four Clinical Cases at a Referral Hospital

Presentations ranged from disseminated vesiculopustular eruptions with systemic symptoms to strictly localised painful perianal lesions without prodrome; one case was initially misdiagnosed as herpes.

General Medicine · Cureus · 11 Sept

Unusual Vascular Claudication in a Seronegative Patient: Raynaud's Phenomenon or Atypical Buerger Disease

Proximal vessels were patent with sluggish distal forearm flow and diminutive radial and ulnar arteries at the wrist; hypercoagulable and vasculitis workup was unrevealing and inflammatory markers stayed normal.

General Medicine · Cureus · 11 Sept

Simultaneous derivation, validation, and comparison of predictor hazard ratios for cardiovascular risk prediction equations in patients with diabetes from high versus non-high income countries: cohort study.

Age hazard ratio per 10 years in women was 1.61 (1.51 to 1.71) in New Zealand versus 2.51 (2.32 to 2.72) in China. Recalibration alone left expected-to-observed ratios of 0.938 in men and 0.809 in women.

Cardiology · BMJ · 11 Sept

Joint impact of pathological burden and cognitive resilience on Alzheimer's disease risk.

Incident AD dementia: pathology hazard ratio 2.50 per s.d. (95% CI 2.30-2.72); resilience hazard ratio 0.51 per s.d. (95% CI 0.48-0.55). The two interacted multiplicatively.

Neurology · Nature Medicine · 11 Sept

Immunogenicity of fractional one-fifth and one-half doses of 17DD yellow fever vaccine compared with full dose in children aged 9-23 months in Uganda: a phase 4, single-blind, randomised clinical trial.

Both fractional doses met non-inferiority (5 percentage-point margin) for seroconversion at 4 weeks; one-half versus full dose difference was -0.17 (95% CI -0.52 to 0.17), with no difference between one-fifth and full doses.

Paediatrics · Lancet · 11 Sept

Teclistamab versus lenalidomide-dexamethasone in high-risk smoldering multiple myeloma: a randomized phase 2 trial.

Complete response 77.8% with teclistamab versus 0% with Rd; MRD negativity 82.2%. At median follow-up 24.5 months, 2-year progression-free survival 92% versus 49%.

Oncology · Nature Medicine · 11 Sept

MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.

Hypoxia-induced MMSDH lactylation at K113 promotes ACSL4 degradation via chaperone-mediated autophagy; MMSDH-mediated ACSL4 propionylation correlated with low ACSL4 and poor NAC response in recipients.

Oncology · Nature cancer · 11 Sept

Oral Health in Hospitalized Adults: Clinical Outcomes and the Role of Dental Expertise

Strongest evidence is for respiratory outcomes; recent randomised evidence gives preliminary support for structured multicomponent oral care reducing non-ventilator hospital-acquired pneumonia on general wards. Chlorhexidine evidence remains inconsistent.

General Medicine · Cureus · 11 Sept

Disseminated Pulmonary Coccidioidomycosis Presenting as a Wedge-Shaped Necrotic Mass Mimicking Malignancy

CT showed a 7.3 × 5.4 cm wedge-shaped necrotic right middle lobe mass with bilateral nodules; biopsy showed granulomatous inflammation with fungal elements, confirmed by serology and BAL PCR

General Medicine · Cureus · 11 Sept

Rapid Resolution of Apophenic Psychosis With Low-Dose Olanzapine in Very Late-Onset Schizophrenia-Like Psychosis

Limited response to quetiapine; rapid and sustained remission on low-dose olanzapine, with symptom recurrence after dose reduction supporting a primary psychotic process

Psychiatry · Cureus · 11 Sept

Comparative Evaluation of Concurrent Carboplatin-Paclitaxel Versus Cisplatin-Etoposide Chemoradiotherapy in Unresectable Non-small Cell Lung Cancer: A Prospective Randomized Study

Tumour-response distribution favoured EP (p=0.029). 12-month PFS 40.0% EP versus 25.0% PC (p=0.206); 12-month OS 80.0% versus 56.3% (p=0.144). EP caused more severe anemia, thrombocytopenia and esophagitis.

Oncology · Cureus · 11 Sept

Factors Influencing Adherence to Mammography Screening Guidelines Among Women From Diverse Cultural Backgrounds: A Systematic Review

Higher adherence was associated with higher educational level, health insurance coverage, older age, and advice by a healthcare professional. Barriers included screening costs, lack of insurance, communication difficulties, cultural and fatalistic beliefs, fear and embarrassment.

Obstetrics & Gynaecology · Cureus · 11 Sept

Right Coronary Artery Thrombosis Causing ST-Elevation Myocardial Infarction After a Coronary Artery Disease Reporting and Data System Score of 0, With Disseminated Intravascular Coagulation During Idiopathic Acute Pancreatitis: A Case Report

A 99% thrombotic subtotal occlusion of the mid-right coronary artery caused inferior STEMI; coronary CT angiography five months earlier had shown an Agatston score of 0 and CAD-RADS 0.

Cardiology · Cureus · 10 Sept

Mass Effect Score Associations in Comatose Trauma Patients With Intracranial Hemorrhage Requiring Mechanical Ventilation: A Retrospective Study

Mortality and adverse outcomes were associated with MES ≥2 (both p 0.05). Failure to follow commands at three months was also associated with MES ≥2 (p 0.05).

Neurology · Cureus · 10 Sept

Weekly Rundown: Cleveland Clinic taps Luminai for AI automation; Quest brings lab testing to Apple Health

US health systems are embedding AI into scheduling and lab-result delivery; expect similar vendor pitches to reach Indian hospitals and clinics within months.

Medicine · Fierce Healthcare · 10 Sept

When Speech Signals Wilson Disease: A Case Report

Kayser-Fleischer rings, reduced serum ceruloplasmin, elevated 24-hour urinary copper, decompensated liver disease, and MRI signal changes in basal ganglia, thalami, and periventricular white matter confirmed Wilson disease; D-penicillamine and zinc led to clinical improvement

Neurology · Cureus · 10 Sept

STAT+: Can AI save rural health care?

Federal bets on AI for rural care may shape what tools reach your understaffed district hospital, though none are proven yet.

General Medicine · STAT News — Health Tech · 10 Sept

Graph AI raises $13.3 Mn in Series A round led by Insight Partners

Company claims live deployments reduced adverse event case processing turnaround from more than three hours to under 10 minutes, a reduction of over 90%, and lowered operating costs by up to 66%

Medicine · Entrackr · 10 Sept

Clinical and Radiographic Success of Pulpotomy in Permanent Teeth With Irreversible Pulpitis: A Systematic Review

Across 16 included studies, pulpotomy consistently gave favourable clinical and radiographic success in permanent teeth with irreversible pulpitis, especially with MTA, Biodentine, CEM and other bioceramics.

General Medicine · Cureus · 10 Sept

Comparison of Fluoroscopy Use Between Two Radiographic Overlay Techniques for Limb Length and Femoral Offset Assessment During Direct Anterior Approach Total Hip Arthroplasty

Unadjusted fluoroscopy time was 60.4 ± 21.2 versus 55.9 ± 19.6 seconds (P = 0.17) and radiation 15.4 ± 13.3 versus 13.0 ± 9.0 mGy (P = 0.17). Time-adjusted ipsilateral use was lower (P = 0.0025).

Orthopaedics · Cureus · 10 Sept

Improving Antibiotic Stewardship Through a Retrospective Study of the Diagnostic Value of Nasal Methicillin-Resistant Staphylococcus aureus Polymerase Chain Reaction for Pneumonia in Intensive Care Unit Settings

Nasal MRSA PCR sensitivity for MRSA in lower respiratory cultures was 90% (18/20); positive predictive value was only 60% (18/30).

General Medicine · Cureus · 10 Sept

Tumor-Related Trigeminal Neuralgia: Clinical Features, Pathophysiology, and the Contemporary Role of Radiosurgery in Tumor Control and Pain Relief

Microsurgery gave a higher proportion of favourable pain outcomes and, in one meta-analysis, longer median time to pain recurrence, with equivalent tumor control, mainly in petroclival and petrous apex meningioma.

Neurology · Cureus · 10 Sept

Peripartum Cardiomyopathy in the Obstetric Intensive Care Unit: Seasonal Associations and the Impact of Winter in the Kashmir Valley

166 of 1,899 admissions (8.74%) were new PPCM; 88 (53.01%) occurred in winter versus 78 (46.99%) across the other three seasons (OR 4.22, 95% CI 3.05-5.85; p < 0.001).

Obstetrics & Gynaecology · Cureus · 10 Sept

At CTA event, federal officials outline AI ambitions as clinicians debate risks

US federal payment policy increasingly shapes which AI tools reach clinics, so adoption decisions may soon follow CMS priorities rather than local evidence alone.

General Medicine · Fierce Healthcare · 10 Sept

Telomerase Reverse Transcriptase (TERT) Mutation at a Price: Telomere Biology Disorder Presenting With Pancytopenia and Cirrhosis Requiring Liver Transplantation

Markedly short telomeres and a heterozygous TERT variant were found. Danazol produced a clear haematologic response, but cirrhosis progressed to portal hypertension requiring orthotopic liver transplantation with sleeve gastrectomy.

Gastroenterology · Cureus · 10 Sept

Temporary Left Ventricular Unloading With Impella as a Bridge to Emergency Surgery for Acute Mitral Bioprosthetic Failure

Cardiac index and mixed venous oxygen saturation rose and oxygenation held on less inspired oxygen; mean pulmonary artery pressure stayed around 40 mmHg and did not keep climbing

Cardiology · Cureus · 10 Sept

Biohaven epilepsy drug suffers FDA hold days after attracting $350M deal

If you have patients on or awaiting BHV-7000 trials, recruitment is now paused pending rodent toxicity review, so discuss alternatives rather than enrolment timelines.

Neurology · Fierce Biotech · 10 Sept

Pre-admission Nutritional Risk as an Independent Predictor of 28-Day Mortality After Hip Fracture: A Retrospective Cohort Study

28-day mortality 14.8% with nutritional risk versus 5.2% without; adjusted OR 3.24 (95% CI 1.65-6.35), barely changed from unadjusted OR 3.21.

Orthopaedics · Cureus · 10 Sept

Cardiorenal Protection in Type 2 Diabetes: A Systematic Review Comparing Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors

SGLT2 inhibitors gave consistent heart failure and kidney benefit; GLP-1 receptor agonists gave strong atherosclerotic cardiovascular benefit and greater weight loss. Combination therapy looked complementary but was not proven superior to selected monotherapy.

Endocrinology · Cureus · 10 Sept

Diaphragmatic Rapid Shallow Breathing Index Versus Diaphragmatic Thickness Fraction for Predicting Weaning Success in Mechanically Ventilated Patients

D-RSBI at 1.2 breaths/min/mm: sensitivity 94.44%, specificity 100%, AUC 0.99 (95% CI 0.97-1.00). DTF: sensitivity 61.11%, specificity 62.50%, AUC 0.65 (95% CI 0.42-0.88). DeLong p = 0.004.

Anaesthesiology · Cureus · 10 Sept

Profile of Invasive Fungal Infections in a Paediatric Haemato-Oncology Unit: A Five-Year Retrospective Cohort Study From a Tertiary Care Centre in South India

33 IFI episodes in 23 patients; Candida and Aspergillus each 43.5%. All 20 Candida episodes were fungemia, 60.0% Candida tropicalis, 100% fluconazole-susceptible. Mortality 26.1% overall: 0 Candida, 30% aspergillosis, 100% mucormycosis.

Paediatrics · Cureus · 10 Sept

Trump officials say AI will help save rural health care. Some leaders in the field don’t believe it

If you work in a low-resource setting, AI tools are being offered as cover for Medicaid cuts that will close rural hospitals and clinics.

General Medicine · STAT News — Health Tech · 10 Sept

Lamotrigine-Associated Visual and Tactile Hallucinations in a Patient With Bipolar Disorder: A Case Report

Visual and tactile hallucinations emerged following lamotrigine dose escalation, an uncommon adverse drug reaction; the abstract reports no numerical data.

Psychiatry · Cureus · 10 Sept

Severe Colchicine Toxicity After Ingestion of a Dose Below Traditionally Reported Lethal Levels: A Case Report

Ingestion of 20 mg (0.26 mg/kg) caused hyperthermia, electrolyte derangement, rhabdomyolysis, coagulopathy and bone marrow suppression; the patient recovered fully with supportive care, GCSF and platelet transfusion.

General Medicine · Cureus · 10 Sept

Association Between Pre-pregnancy Obesity and Adverse Obstetric Outcomes: A Retrospective Cohort Study at a Secondary Care Center in Tbilisi, Georgia

Hypertensive disorders, cesarean delivery and macrosomia (23/145 vs 23/283; adjusted OR 2.02, 95% CI 1.07-3.82) were more frequent with obesity. PPH and preterm birth showed no significant association.

Obstetrics & Gynaecology · Cureus · 10 Sept

Characterization and Antimicrobial Susceptibility Patterns of Clinically Significant Non-fermenting Gram-Negative Bacilli Isolated From Clinical Specimens

Pseudomonas aeruginosa 61 (48.03%), Acinetobacter baumannii 53 (41.73%), Stenotrophomonas maltophilia 13 (10.24%). A. baumannii and P. aeruginosa were highly carbapenem-resistant; S. maltophilia remained susceptible to antibiotics tested.

General Medicine · Cureus · 10 Sept

Clinicopathological Machine Learning Models for Mortality Risk Prediction in Head and Neck Squamous Cell Carcinoma: A Retrospective Analysis of the The Cancer Genome Atlas Head-Neck Squamous Cell Carcinoma (TCGA-HNSC) Cohort

Clinicopathological-only AUCs ranged 0.666 to 0.698. Adding genomic features improved every classifier, best random forest AUC 0.708 to 0.727. Stage IV HR 4.07 (95% CI 1.50-11.03).

Oncology · Cureus · 10 Sept