Archive

Evommune gives up hope for MRGPRX2 antagonist to treat itch after latest phase 2 fail

MRGPRX2 blockade fails again in itch—no new option for chronic pruritus patients; consider alternative pathways in refractory cases.

Medicine · Fierce Biotech · 9 Sept

Diagnostic Diplopia: Isolated Oculomotor Nerve Palsy With Normal Imaging

When imaging is normal in isolated oculomotor palsy, don't settle for microvascular cause—consider vasculitis, aneurysm, or infiltrative disease before discharging.

Neurology · Cureus · 9 Sept

ICMR-NIV study detects insecticide resistance in dengue vector mosquitoes in parts of Pune

If you manage dengue cases, expect control failures in Pune; consider alternative vector control and patient counselling on prevention.

General Medicine · ETHealthworld · 9 Sept

Solstice rises with $225M series A to advance next-gen CTLA-4 immunotherapy into phase 2

This funding accelerates a next-gen CTLA-4 inhibitor into phase 2, potentially offering better-tolerated checkpoint therapy for your cancer patients.

Oncology · Fierce Biotech · 9 Sept

Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival and event-free survival by pathological response in a global, randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

Overall survival significantly improved with durvalumab versus placebo (hazard ratio 0·78, 95% CI 0·63-0·96; p=0·021). Treatment-related deaths occurred in 6 (1%) versus 2 (<1%).

Oncology · Lancet · 9 Sept

Effect of exercise on bone health in middle aged and older adults: hierarchical network meta-analysis of randomised trials.

Lumbar spine BMD rose with brisk walking or jogging (0.013 g/cm2, 95% CrI 0.006 to 0.021) and combined aerobic-resistance exercise (0.013, 0.010 to 0.016). Mixed aerobic exercise reduced fractures (OR 0.29, 0.11 to 0.78).

Orthopaedics · BMJ · 9 Sept

Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial.

Mitiperstat (pooled doses) did not improve KCCQ-TSS (placebo-corrected difference -1.4 points, 95% CI -3.9 to 1.2; P=0.29) or 6MWD (3.8 m, 95% CI -3.1 to 10.8; P=0.28) or any secondary endpoint.

Cardiology · Nature Medicine · 9 Sept

Commensal Nakaseomyces glabratus migrates into prostate tumors to accelerate cancer progression.

N. glabratus was enriched in fecal, blood and tumour samples of castration-resistant prostate cancer patients and correlated with poor overall survival; in castrated mice it accelerated progression via PMN-MDSC infiltration.

Oncology · Nature cancer · 9 Sept

Inhaled siRNA therapy targeting RAGE for pulmonary inflammation: a first-in-human randomized trial.

ARO-RAGE was safe and well tolerated with no clinically relevant changes in chest x-ray, pulmonary function or systemic inflammation; prolonged dose-responsive decreases in serum and bronchoalveolar lavage sRAGE indicated target engagement.

Medicine · Nature Medicine · 9 Sept

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants: The AIROPLANE Cluster Randomized Crossover Trial.

Ongoing respiratory support when leaving the delivery room: 700 of 964 (72.6%) with Fio2 0.30 vs 626 of 854 (73.3%) with Fio2 0.21; risk difference -0.83 (95% CI, -4.33 to 2.67).

Paediatrics · JAMA · 9 Sept

Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

MWT sleep latency rose 14.3-19.8 minutes with oveporexton versus -0.4 to -0.8 with placebo; ESS fell 9.7-11.8 versus 1.5-1.7; cataplexy fell 79.0-88.8% versus 27.7-39.1% (all P<0.001).

Neurology · NEJM · 9 Sept

Nephrotic Syndrome During Ipilimumab Plus Nivolumab Therapy for Sarcomatoid Malignant Pleural Mesothelioma: A Case Report of Nivolumab Rechallenge Without Recurrence of Nephrotic Syndrome

Nephrotic syndrome emerged during ipilimumab plus nivolumab and resolved with drug cessation plus prednisolone. Nivolumab alone, given with a tapering prednisolone dose after tumour regrowth, did not reproduce nephrotic syndrome.

Medicine · Cureus · 9 Sept

Cytomegalovirus (CMV) Central Nervous System Infection and Recurrent Posterior Circulation Ischemic Strokes in an Immunocompetent Patient

CSF showed lymphocytic meningitis, elevated protein, normal glucose; CMV genome detected. Ganciclovir normalized CSF, but patient died of hemorrhagic complications.

Medicine · Cureus · 9 Sept

Spontaneous Tumor Lysis Syndrome in Refractory Metastatic Esophageal Adenocarcinoma Presenting With Septic Shock

Laboratory evaluation showed hyperuricemia (18.1 mg/dL), hyperkalemia (7.6 mmol/L), hyperphosphatemia (7.8 mg/dL), and acute kidney injury; findings met Cairo-Bishop thresholds for TLS.

Medicine · Cureus · 9 Sept

Chylous Ascites Following Thoracic Drainage in a Patient With Previously Undiagnosed Cirrhosis

Chylous ascites developed within days of Seldinger chest drain insertion; resolved with dietary fat restriction and supportive care.

Medicine · Cureus · 8 Sept

Repeated Thrombolysis Using Tenecteplase in a Patient With Early Recurrent Ischaemic Stroke

Patient received tenecteplase twice and had good outcome; no specific efficacy or safety numbers reported

Medicine · Cureus · 8 Sept

Outcomes of Open, Percutaneous, and Closed Treatment of Isolated Mandibular Condylar Fractures

Across severity strata, 30-day readmission rates ranged from 4.8% to 8.3%; open, percutaneous, and closed approaches did not differ significantly (all p ≥ 0.711).

Medicine · Cureus · 8 Sept

Longitudinal COVID-19 Vaccination Records and SARS-CoV-2 Infection Among Older Long-Term Care Facility Residents in Okinawa, Japan: A Retrospective Descriptive Study

Linked documented infection occurred in 89/232 residents (38.4%; 95% CI, 32.3%-44.8%). Recurrent infection occurred in 24/89 residents (27.0%; 95% CI, 18.8%-37.0%).

Medicine · Cureus · 8 Sept

Transcatheter Aortic Valve-in-Surgical Aortic Valve (TAV-in-SAV) for Structural Valve Degeneration of Post-Surgical Aortic Valve Replacement (SAVR) With the 3D-Nicks Procedure: A Case Report

Postoperative echocardiography showed mean PG 6 mmHg, EOAi 1.29 cm²/m², stable at three-year follow-up (EOAi 1.16 cm²/m²).

Medicine · Cureus · 8 Sept

Prenatal Diagnosis and Obstetrical Challenges of a Massive Fetal Ascites Affecting One Fetus in a Dichorionic Diamniotic Twin Pregnancy: A Case Report

At 24 weeks, massive fetal ascites with bilateral hydrocele was diagnosed in one male twin. Ultrasound estimated weight at approximately 3.3 kg, but actual birth weight was 2.2 kg; the infant died approximately one hour after birth.

Medicine · Cureus · 8 Sept

Forus secures $150M series C to grow AI-powered medication access platform

If adopted locally, this could streamline prior authorisations and medication access workflows across specialties, reducing delays for patients starting treatment.

General Medicine · Fierce Healthcare · 8 Sept

Hospitals need better SUD care. Team-based approaches are bringing results

Multidisciplinary consult teams improve substance use disorder care in hospitals, aligning with new ASAM guidelines—consider integrating such teams to enhance patient outcomes.

Psychiatry · Fierce Healthcare · 8 Sept

Quel Health launches telehealth platform for addiction treatment using GLP-1s

Offers a new GLP-1-based telehealth option for addiction, potentially expanding access to care.

Medicine · Fierce Healthcare · 8 Sept

AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

FDA priority review for itepekimab could give COPD patients a new biologic option beyond standard inhalers, potentially reducing exacerbations in this hard-to-treat population.

General Medicine · Fierce Biotech · 8 Sept

FDA approves AstraZeneca’s Etcamah, opening ctDNA-guided treatment paradigm in breast cancer

ctDNA-guided use of camizestrant could let you switch endocrine therapy earlier in ER-positive breast cancer when molecular relapse appears before radiologic progression.

Medicine · Fierce Biotech · 8 Sept

Spyre's 3-pronged IBD strategy on track as IL-23 antibody rounds off trio of phase 2 wins

Another anti-IL-23 antibody shows phase 2 efficacy in IBD, widening the biologic armamentarium for patients who fail existing therapies.

Gastroenterology · Fierce Biotech · 8 Sept

Bristol Myers’ pivotal CAR-T multiple myeloma trial hits primary endpoint

A GPRC5D-directed CAR-T reaching its primary endpoint could expand options for relapsed multiple myeloma beyond BCMA-targeted therapy.

Medicine · Fierce Biotech · 8 Sept

Frailty in Cardiorenal Care: A Geriatric Perspective on the 2026 European Society of Cardiology Guidelines

No clinical results reported. Authors propose considering frailty, sarcopenia, cognition, multimorbidity, and function to individualize organ-protective treatment in older adults.

Medicine · Cureus · 8 Sept

Parakeet Health lands major AI partnership with national dermatology group Qualderm

If adopted, agentic AI could help dermatology groups triage referrals and streamline access, potentially reducing wait times for patients needing specialist review.

Medicine · Fierce Healthcare · 8 Sept

SC flags attacks on doctors in Maharashtra

Violence against doctors affects emergency care delivery and staff safety; any court signal on stricter protection may influence hospital security and reporting practices.

Medicine · ETHealthworld · 8 Sept

Boston Scientific recalls spinal cord implant in wake of more than 1k serious injuries

Check patients with this implant for fracture risk; report adverse events promptly if you use this device.

Medicine · Fierce Biotech · 8 Sept

Fundly.ai Raises $4 Mn To Scale Pharma Payments, Commerce Infra

Speeds medicine procurement and payment for clinics; reduces cash-flow delays in pharma supply.

Medicine · Inc42 · 8 Sept

N-terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) Versus Artificial Intelligence-Enabled Electrocardiography for the Diagnosis of Acute Heart Failure in Emergency Departments: A Systematic Review

AI-ECG AUC 0.88-0.94, outperformed NT-proBNP in direct comparisons (0.89 vs 0.80; 0.91-0.92 vs 0.75). NT-proBNP sensitivity 96%-99%, specificity 54%-56% at 300 pg/mL.

Medicine · Cureus · 8 Sept

Sentinel Lymph Node Positivity by Tumour Grade in Older Women With Breast Cancer: A Cross-Verified Retrospective Cohort Study

SLNB positive in 3/39 (7.7%; 95% CI 2.7-20.3%). Grade 2: 19.8% (95% CI 13.9-27.5%), Grade 3: 13.7% (95% CI 6.8-25.7%). No axillary recurrences.

Medicine · Cureus · 8 Sept

AI in healthcare: Remote monitoring, ICU optimisation to be next growth frontiers

Expect AI tools to flag deteriorating patients earlier, potentially reducing ICU transfers and bedside workload.

Medicine · ETHealthworld · 8 Sept

Bruton Tyrosine Kinase Inhibitor-Based Therapy Versus Rituximab-Containing Regimens for Chronic Lymphocytic Leukemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

BTK inhibitor-based therapy significantly prolonged PFS in eight trials (pooled HR, 0.42; 95% CI: 0.24-0.73; P=0.002; I²=93%). ORR was nonsignificant: 440 of 543 (81.0%) versus 350 of 491 (71.3%) (RR: 1.18; 95% CI: 0.98-1.42; P=0.08; I²=86%). OS also remained nonsignificant (HR: 0.67; 95% CI: 0.40-1.11; P=0.12; I²=48%).

Medicine · Cureus · 8 Sept

B2B pharma distribution startup Fundly.ai raises $4 Mn led by Accel, Multiply

Fundly.ai raised $4 million led by Accel and Multiply Ventures, with around $0.9 million in venture debt. The company had earlier raised $3 million seed funding in 2023.

Medicine · Entrackr · 8 Sept

Spiked Helmet Sign Associated With Acute Gastric Distension and Hemodynamic Instability: A Case Report

Sinus tachycardia at 135 bpm with spike-helmet morphology in lead II; after decompression, heart rate 83 bpm and morphology disappeared

Medicine · Cureus · 8 Sept

Novartis’ centerpiece of $12B Avidity buyout flunks ‘crucial’ phase 3 test

Del-desiran missed its phase 3 primary endpoint, so it should not be assumed to improve outcomes for patients with Duchenne muscular dystrophy.

Medicine · Fierce Biotech · 8 Sept

Questions Ophthalmology Trainees Ask About Ocular Syphilis: A Question-Driven Narrative Review

The review consolidated 26 questions into 15 across seven domains. It concluded ocular syphilis is best managed with a neurosyphilis treatment regimen, diagnosed with combined treponemal and nontreponemal tests, and monitored with serial nontreponemal titers.

Medicine · Cureus · 8 Sept