Archive

Red Cell Distribution Width-to-Platelet Count Ratio as an Early Marker of Severity in Acute Pancreatitis: A Diagnostic Accuracy Study at a Tertiary Care Center

A single admission CBC-derived ratio may flag severe acute pancreatitis before 48-hour scores are available, letting you escalate care earlier.

Gastroenterology · Cureus · 14 Sept

Emergency Department Management of Ankle Fractures: A Narrative Review

Half of ankle fractures follow simple falls and a quarter need surgery, so your ED workup and splinting decisions determine who gets timely orthopaedic referral.

Orthopaedics · Cureus · 14 Sept

States are betting millions on remote monitoring. Providers, tech groups say proposed Medicare policy could undercut it

If Medicare cuts remote monitoring reimbursement, the RPM programmes your rural patients depend on may lose funding, so check whether your service is exposed.

General Medicine · Fierce Healthcare · 14 Sept

The Impact of Assisted Reproduction Technology on Breast Cancer Risk for Women With Infertility: Current Insights and Future Perspectives

No consistent evidence links ovarian stimulation to breast cancer, so you can counsel infertility patients that ART has not been shown to raise their risk.

Obstetrics & Gynaecology · Cureus · 14 Sept

Prevalence and Pattern of Thyroid Dysfunction Among Women of Reproductive Age With Abnormal Uterine Bleeding: A Prospective Observational Study

Thyroid dysfunction in 45/150 (30.0%): overt hypothyroidism 19/45 (42.2%), subclinical hypothyroidism 16/45 (35.6%), overt hyperthyroidism 10/45 (22.2%). Mean TSH 6.20 ± 4.89 vs 2.54 ± 0.96 mIU/L (p < 0.001).

Obstetrics & Gynaecology · Cureus · 14 Sept

Axoltis misses the mark in phase 2 ALS study, but still strives to move towards the clinic

A negative phase 2 in ALS means no new option is imminent; continue standard multidisciplinary care and consider enrolling patients in other ongoing ALS trials.

Neurology · Fierce Biotech · 14 Sept

Knowtex launches frontier healthcare AI lab

A vendor already used across 200+ specialties is expanding its AI platform, so expect more ambient documentation and coding tools pitched to your hospital.

Medicine · Fierce Healthcare · 14 Sept

Extensor Mechanism Reconstruction Following Periprosthetic Joint Infection After Total Knee Arthroplasty: A Systematic Review

No formal comparison established superiority or equivalence of allograft versus synthetic mesh. Postoperative Knee Society Scores frequently exceeded 70 points, extensor lag improved to less than 10°, and flexion ranged from 95° to 110°.

Orthopaedics · Cureus · 14 Sept

Corbus posts phase 1 obesity data for drug mechanism that defeated Novo, Sanofi

A peripherally restricted CB1 inverse agonist may deliver weight loss without the neuropsychiatric toxicity that ended earlier CB1 obesity programmes; phase 2 will test that claim.

Endocrinology · Fierce Biotech · 14 Sept

AI, trauma, bionics: India’s top institutes join forces to develop medical care for soldiers

Trauma and bionics protocols developed for battlefield injuries will likely flow into civilian emergency and orthopaedic practice at these institutes.

General Surgery · ETHealthworld · 14 Sept

The Effect of Oral Isotretinoin on Quality of Life in Patients With Acne Vulgaris: A Systematic Review and Meta-Analysis of Patient-Reported Outcomes

Pooled DLQI fell significantly after isotretinoin: SMD −1.49 (95% CI −2.48 to −0.51). Heterogeneity was substantial (I² = 98.1%). Mixed-severity and severe or treatment-resistant subgroups both improved, with no significant difference between them.

Medicine · Cureus · 14 Sept

Persistent HyperCKemia Beyond Post-Viral Myositis: A Case of Anti-HMGCR Immune-Mediated Necrotizing Myopathy

CK fell to 376 U/L (N 30-200 U/L) four months after admission on high-dose corticosteroids then methotrexate, with complete recovery of muscle strength and swallowing.

Neurology · Cureus · 14 Sept

Disciform Keratitis That Improves With Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitor Treatment for Ovarian Cancer but Recurs Upon Discontinuation of Treatment

VZV DNA detected in aqueous humour by PCR. Keratitis resolved with oral valacyclovir and topical betamethasone, recurred one month after olaparib stopped, and resolved again with frequent topical betamethasone.

Ophthalmology · Cureus · 14 Sept

Rhabdomyolysis Following Rapid Correction of Acute Hyponatraemia in a Patient With Psychogenic Polydipsia

Serum sodium rose from 117 mmol/L to 131 mmol/L within six hours; CK was already elevated on admission and peaked at 60,672 U/L, with preserved renal function.

General Medicine · Cureus · 14 Sept

India may get own dengue vax by next year end: ICMR DG

A single-dose indigenous vaccine covering all four serotypes could reach Indian clinics by late 2026, but low case counts may delay trial unblinding.

General Medicine · ETHealthworld · 14 Sept

Roche, MediLink notch phase 3 lung cancer win but trail GSK on cross-trial survival

A new B7-H3 ADC option is coming for relapsed SCLC, but its median survival trails GSK's rival, so sequencing and cross-trial comparisons will matter.

Oncology · Fierce Biotech · 14 Sept

Renal Dysfunction and Cardiorenal Syndrome in Acute Heart Failure: A Systematic Review of Residual Congestion and Decongestion Response

Residual congestion was consistently associated with worse clinical outcomes, while worsening renal function during effective decongestion did not uniformly predict adverse renal or cardiovascular events.

Cardiology · Cureus · 14 Sept

Quantitative Neuromuscular Monitoring in General Anesthesia: A Systematic Review of Recovery and Safety Outcomes

TOF ratio of at least 0.90 was the common threshold for adequate recovery; residual blockade was associated with oxygen requirement, hypoxemia, critical respiratory events, and pulmonary complications.

Anaesthesiology · Cureus · 14 Sept

Late-Onset Neonatal Cyanosis Secondary to Methemoglobinemia in a Preterm, Small-for-Gestational-Age Infant: A Case Report

In a preterm neonate with unexplained desaturations unresponsive to oxygen, check methemoglobin — methylene blue and vitamin C correct it, and pulse oximetry alone will mislead you.

Paediatrics · Cureus · 14 Sept

Global nutrition experts back FSSAI warning labels, seek stricter rules

Stricter front-of-pack warnings on high sugar, salt and saturated fat could make packaged-food counselling easier for patients with diabetes, hypertension and obesity.

General Medicine · ETHealthworld · 14 Sept

Manipal Hospitals scouts for acquisitions in Andhra, Keralam, Delhi-NCR; bets on AI-led healthcare

Your hospital's competitor is scaling AI-assisted nursing and monitoring across 2,400 new beds, which will shift referral patterns and staffing expectations in these regions.

Medicine · ETHealthworld · 14 Sept

Managing Cardiac Amyloidosis in a Rural Cardiology Practice: Bridging Gaps in Specialized Evaluation and Disease-Modifying Treatment

All three patients were effectively evaluated using a streamlined diagnostic pathway and started on disease-modifying therapy promptly, despite limited access to advanced imaging, biopsy and genetic testing

Cardiology · Cureus · 14 Sept

Suspected Seronegative Spondyloarthropathy in a Young Woman With Ulcerative Colitis and Concurrent Bleeding Symptoms

In UC patients with new joint pain, consider HLA-B27-negative spondyloarthropathy even without sacroiliitis, and screen for concurrent bleeding before starting NSAIDs.

Gastroenterology · Cureus · 14 Sept

Anatomic Reconstruction of Acute Posterior Shoulder Instability With Reverse Hill-Sachs Lesions: A Report of Two Cases

At 24 months neither patient had recurrent instability or reoperation. Forward elevation 160° in both; ASES scores 90 and 88; SANE 95 and 93; pain 0 of 10 in both.

Orthopaedics · Cureus · 14 Sept

Pneumococcal population structure influences the effects of air pollution on invasive disease risk in South Africa.

Air pollution raises invasive pneumococcal disease risk unevenly across serotypes, so vaccinating high-risk patients matters more on bad-air days.

General Medicine · Nature microbiology · 14 Sept

Circulating tumor DNA-guided de-escalation or escalation of adjuvant therapy in high-risk stage II and stage III colon cancer: the phase 2 PEGASUS trial.

The 2-year relapse-free rate among ctDNA-negative patients was 88% (90% CI 81-93%), below the predefined 92% threshold; the primary endpoint was not met. ctDNA-positive patients had a 3-year disease-free survival of 58% versus 83% (HR 2.71; 95% CI 1.35-5.45; P=0.0036).

Oncology · Nature cancer · 14 Sept

Adoption of Adjunctive Azithromycin for Unscheduled Cesarean Delivery and Postpartum Infections.

Azithromycin use at cesarean rose from 2.2% to 39.6% (adjusted difference-in-differences 37.6 percentage points, 95% CI 33.1 to 42.2); postpartum infection fell 2.0 percentage points (95% CI -2.6 to -1.4).

Obstetrics & Gynaecology · JAMA · 14 Sept

Idiopathic Normal Pressure Hydrocephalus: A Review.

Gait disturbance occurs in 85%-95%, urinary dysfunction in 75%-90%, cognitive impairment in 60%-80%. After shunting, gait velocity improves in 75%-80%, cognition and urinary symptoms in 50%-70%.

Neurology · JAMA · 14 Sept

Surgical Technique – The “Derriere View” for Evaluation of Guidewire Position in Cephalomedullary Nailing of Intertrochanteric Femur Fractures

An added intraoperative fluoroscopic view may catch malpositioned guidewires before reaming, reducing cut-out in elderly IT fracture nailing.

Orthopaedics · Cureus · 14 Sept

Abridge expands into revenue cycle with AI-powered pre-bill claim review

If your hospital adopts this, AI will flag documentation gaps before claims go out, shifting CDI queries from coders to your notes.

Medicine · Fierce Healthcare · 14 Sept

Ischemic Stroke During Rivaroxaban Therapy: The Importance of Food-Dependent Absorption and Careful Assessment Before Antithrombotic Escalation

Before adding an antiplatelet after a stroke on rivaroxaban, check food-dependent absorption and timing — escalation may raise bleeding without fixing the cause.

Cardiology · Cureus · 14 Sept

Transient Post-infectious Multisystem Inflammatory Overlap Presentation in a Pediatric Patient With Neurological, Hepatic, Gastrointestinal, and Autoimmune Manifestations: A Rare Case From Azerbaijan

Transient autoantibody positivity and incidental neuroinflammatory imaging changes, hepatic steatosis and gastrointestinal inflammation appeared disproportionate to clinical status and resolved without immunosuppression or invasive intervention

Paediatrics · Cureus · 13 Sept

Transfascial Paraspinal Versus Conventional Open Posterior Pedicle Screw Fixation for Thoracolumbar Fractures: A Randomized Controlled Trial

Transfascial group had less blood loss (173.76±37.94 vs 294.00±89.35 mL, p<0.001), lower drain output (37.60±18.94 vs 93.20±43.48 mL, p<0.001), shorter stay (3.08±1.82 vs 5.48±4.30 days, p=0.012); Cobb correction similar (4.40±1.15° vs 4.60±1.19°, p=0.549).

Orthopaedics · Cureus · 13 Sept

When Fever Hides Fire: A Systematic Review of Clinical and Digital Approaches to Early Recognition of Pediatric Sepsis

Approaches performed well ruling out sepsis in low-risk children, but case detection and alert burden varied by thresholds, settings, and sepsis definitions; no approach was consistently superior

Paediatrics · Cureus · 13 Sept

Comparative Outcomes of Transoral Robotic Surgery Versus Open Surgery in Head and Neck Cancer: A Systematic Review and Meta-Analysis

TORS was associated with lower tracheostomy rates, shorter hospital stay, and reduced feeding tube dependence; recurrence and overall survival favoured TORS; complications and positive margins were comparable.

Oncology · Cureus · 13 Sept

Integrated Clinical, Biological, and Echocardiographic Factors Independently Associated With In-Hospital Mortality in Infective Endocarditis: A Single-Centre Cohort Study From Morocco

In-hospital mortality was 27.7% (72/260). Independent predictors: septic shock (aOR 28.45; 95% CI 3.42-106.80), vegetation >15 mm (aOR 2.50; 95% CI 1.00-6.20), male sex (aOR 2.68; 95% CI 1.12-6.42), anaemia and severe renal dysfunction.

Cardiology · Cureus · 13 Sept

Cytomegalovirus Retinitis Mimicking Acute Retinal Necrosis During Upadacitinib Therapy

Aqueous humor PCR detected CMV DNA at 6.85 × 10⁴ copies/mL; HSV and VZV were negative, HIV RNA undetectable, and peripheral-blood CMV antigenemia negative. Vision remained poor despite treatment.

Ophthalmology · Cureus · 13 Sept

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC.

An explainable AI tool trained on 2,396 real-world NSCLC cases may sharpen immunotherapy selection beyond PD-L1 alone, but awaits validation before replacing current scoring.

Oncology · Nature Medicine · 13 Sept

Most-favoured-nation pricing for prescription drugs in US Medicare: a cohort study.

US Medicare MFN rebates could reset global reference prices, indirectly squeezing Indian drug supply and pricing for the medicines you prescribe.

General Medicine · Lancet · 13 Sept

Alternative Medicine and Nutritional Therapy in Adult Inflammatory Bowel Disease in India: A Move Towards Holistic Practice

No primary outcome or effect size reported. Curcumin is described as a safe, feasible adjunct in ulcerative colitis; exclusive enteral nutrition shows promise in Crohn's disease but is not standard practice.

Gastroenterology · Cureus · 13 Sept