Archive

Tumor-Related Trigeminal Neuralgia: Clinical Features, Pathophysiology, and the Contemporary Role of Radiosurgery in Tumor Control and Pain Relief

Microsurgery gave a higher proportion of favourable pain outcomes and, in one meta-analysis, longer median time to pain recurrence, with equivalent tumor control, mainly in petroclival and petrous apex meningioma.

Neurology · Cureus · 2d

Peripartum Cardiomyopathy in the Obstetric Intensive Care Unit: Seasonal Associations and the Impact of Winter in the Kashmir Valley

166 of 1,899 admissions (8.74%) were new PPCM; 88 (53.01%) occurred in winter versus 78 (46.99%) across the other three seasons (OR 4.22, 95% CI 3.05-5.85; p < 0.001).

Obstetrics & Gynaecology · Cureus · 2d

At CTA event, federal officials outline AI ambitions as clinicians debate risks

US federal payment policy increasingly shapes which AI tools reach clinics, so adoption decisions may soon follow CMS priorities rather than local evidence alone.

General Medicine · Fierce Healthcare · 2d

Telomerase Reverse Transcriptase (TERT) Mutation at a Price: Telomere Biology Disorder Presenting With Pancytopenia and Cirrhosis Requiring Liver Transplantation

Markedly short telomeres and a heterozygous TERT variant were found. Danazol produced a clear haematologic response, but cirrhosis progressed to portal hypertension requiring orthotopic liver transplantation with sleeve gastrectomy.

Gastroenterology · Cureus · 2d

Temporary Left Ventricular Unloading With Impella as a Bridge to Emergency Surgery for Acute Mitral Bioprosthetic Failure

Cardiac index and mixed venous oxygen saturation rose and oxygenation held on less inspired oxygen; mean pulmonary artery pressure stayed around 40 mmHg and did not keep climbing

Cardiology · Cureus · 2d

Biohaven epilepsy drug suffers FDA hold days after attracting $350M deal

If you have patients on or awaiting BHV-7000 trials, recruitment is now paused pending rodent toxicity review, so discuss alternatives rather than enrolment timelines.

Neurology · Fierce Biotech · 2d

Pre-admission Nutritional Risk as an Independent Predictor of 28-Day Mortality After Hip Fracture: A Retrospective Cohort Study

28-day mortality 14.8% with nutritional risk versus 5.2% without; adjusted OR 3.24 (95% CI 1.65-6.35), barely changed from unadjusted OR 3.21.

Orthopaedics · Cureus · 2d

Cardiorenal Protection in Type 2 Diabetes: A Systematic Review Comparing Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors

SGLT2 inhibitors gave consistent heart failure and kidney benefit; GLP-1 receptor agonists gave strong atherosclerotic cardiovascular benefit and greater weight loss. Combination therapy looked complementary but was not proven superior to selected monotherapy.

Endocrinology · Cureus · 2d

Diaphragmatic Rapid Shallow Breathing Index Versus Diaphragmatic Thickness Fraction for Predicting Weaning Success in Mechanically Ventilated Patients

D-RSBI at 1.2 breaths/min/mm: sensitivity 94.44%, specificity 100%, AUC 0.99 (95% CI 0.97-1.00). DTF: sensitivity 61.11%, specificity 62.50%, AUC 0.65 (95% CI 0.42-0.88). DeLong p = 0.004.

Anaesthesiology · Cureus · 2d

Profile of Invasive Fungal Infections in a Paediatric Haemato-Oncology Unit: A Five-Year Retrospective Cohort Study From a Tertiary Care Centre in South India

33 IFI episodes in 23 patients; Candida and Aspergillus each 43.5%. All 20 Candida episodes were fungemia, 60.0% Candida tropicalis, 100% fluconazole-susceptible. Mortality 26.1% overall: 0 Candida, 30% aspergillosis, 100% mucormycosis.

Paediatrics · Cureus · 2d

Trump officials say AI will help save rural health care. Some leaders in the field don’t believe it

If you work in a low-resource setting, AI tools are being offered as cover for Medicaid cuts that will close rural hospitals and clinics.

General Medicine · STAT News — Health Tech · 2d

Lamotrigine-Associated Visual and Tactile Hallucinations in a Patient With Bipolar Disorder: A Case Report

Visual and tactile hallucinations emerged following lamotrigine dose escalation, an uncommon adverse drug reaction; the abstract reports no numerical data.

Psychiatry · Cureus · 2d

Severe Colchicine Toxicity After Ingestion of a Dose Below Traditionally Reported Lethal Levels: A Case Report

Ingestion of 20 mg (0.26 mg/kg) caused hyperthermia, electrolyte derangement, rhabdomyolysis, coagulopathy and bone marrow suppression; the patient recovered fully with supportive care, GCSF and platelet transfusion.

General Medicine · Cureus · 2d

Association Between Pre-pregnancy Obesity and Adverse Obstetric Outcomes: A Retrospective Cohort Study at a Secondary Care Center in Tbilisi, Georgia

Hypertensive disorders, cesarean delivery and macrosomia (23/145 vs 23/283; adjusted OR 2.02, 95% CI 1.07-3.82) were more frequent with obesity. PPH and preterm birth showed no significant association.

Obstetrics & Gynaecology · Cureus · 2d

Characterization and Antimicrobial Susceptibility Patterns of Clinically Significant Non-fermenting Gram-Negative Bacilli Isolated From Clinical Specimens

Pseudomonas aeruginosa 61 (48.03%), Acinetobacter baumannii 53 (41.73%), Stenotrophomonas maltophilia 13 (10.24%). A. baumannii and P. aeruginosa were highly carbapenem-resistant; S. maltophilia remained susceptible to antibiotics tested.

General Medicine · Cureus · 2d

Clinicopathological Machine Learning Models for Mortality Risk Prediction in Head and Neck Squamous Cell Carcinoma: A Retrospective Analysis of the The Cancer Genome Atlas Head-Neck Squamous Cell Carcinoma (TCGA-HNSC) Cohort

Clinicopathological-only AUCs ranged 0.666 to 0.698. Adding genomic features improved every classifier, best random forest AUC 0.708 to 0.727. Stage IV HR 4.07 (95% CI 1.50-11.03).

Oncology · Cureus · 2d

First Indian genome-wide study sheds light on genetic risk of endometriosis

Confirms Indian women share known endometriosis risk loci plus population-specific signals, supporting earlier genetic suspicion in unexplained pelvic pain and infertility.

Obstetrics & Gynaecology · ETHealthworld · 2d

Front-of-pack labels: Food Inc bats for per-serving benchmark in SC, not FSSAI’s ‘per 100 gm’ plan

Per-serving labels understate salt, sugar and fat in foods patients eat in larger amounts, so the benchmark chosen decides how useful your dietary counselling is.

General Medicine · ETHealthworld · 2d

Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.

At 90 days, 69.7% on loberamisal reached mRS 0-1 versus 56.3% on placebo (risk difference 13.28%, 95% CI 7.24%-19.32%)

Neurology · JAMA · 2d

Outbreak of Severe Methemoglobinemia during Maritime Migration.

Median methemoglobin 44.6% (IQR 32.0–55.7); 43% had levels ≥50%. Methylene blue used in 90%. Hemolytic anemia in 38 patients; 2 died. N-methylaniline or metabolites found in 37 of 39 tested patients (95%).

General Medicine · NEJM · 2d

Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health.

Self-reported depression and anxiety prevalence exceeded national estimates; concordance with UK Biobank was r=0.78 for disease prevalence and r=0.80 for clinical correlates. Lung cancer rates were lower than national data.

General Medicine · Nature Medicine · 2d

Rheumatoid Arthritis in Adults: A Review.

About 40% of newly diagnosed patients achieve CDAI remission within 6 months on first-line DMARDs; adding biological DMARDs or JAK inhibitors increases remission or low disease activity to approximately 80%.

General Medicine · JAMA · 2d

COVID-19 vaccination around immune checkpoint inhibitor start and survival in a nationwide cohort of patients with cancer.

Pre-ICI mRNA vaccination: HR 0.90 (95% CI 0.87-0.94) at 1-3 months, 0.96 (0.93-1.00) at 6 months, no association after 12 months. Post-ICI: HR 0.84 (0.80-0.88) at 3 months.

Oncology · Nature Medicine · 2d

Treatment Decisions in Multiple Myeloma.

Quadruplet induction is now standard in newly diagnosed myeloma and the role of autologous transplantation is being reevaluated; in relapse, BCMA-directed CAR T cells, bispecific antibodies and antibody-drug conjugates are sequenced by T-cell fitness and multiantigen targeting.

Oncology · NEJM · 2d

A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial.

No treatment-related serious adverse events, deaths, or grade ≥3 CRS/neurotoxicity; CRS mostly grade 1 (91.6%, 11/12). Exploratory: 80% (8/10) achieved LLDAS and 60% (6/10) DORIS at 12 months.

General Medicine · Nature Medicine · 2d

STAT+: U.K. unveils recommendations for regulating AI in medicine

Signals future approval and liability standards for AI tools you may adopt; watch for alignment with your local regulators.

Medicine · STAT News — Health Tech · 2d

Cardiovascular Comorbidities in Knee Osteoarthritis: Prevalence, Functional association, and Therapeutic Consequences

98 (62.0%) had at least one cardiovascular comorbidity. Those affected had worse Lequesne scores (12.4 ± 4.2 vs. 10.3 ± 4.6; p = 0.004) and lower systemic NSAID use (31.6% vs. 55.0%; p = 0.01).

Orthopaedics · Cureus · 2d

Surgical Deconstruction of Recurrent Basilar Apex Aneurysms Refractory to Endovascular Treatment

Both patients achieved safe, immediate and durable aneurysm disconnection; angiographic posterior communicating artery presence and an intraoperative perforator-free zone were key to the approach

Neurology · Cureus · 3d

STAT+: ARPA-H to invest $62 million to develop FDA-authorized AI to help treat heart failure

AI-guided heart failure therapy could soon be FDA-authorized, potentially changing how you titrate medications and monitor patients.

Cardiology · STAT News — Health Tech · 3d

STAT+: Can AI fix the emergency room?

AI won't solve ER overcrowding or staffing shortages; focus on systemic fixes, not tech hype.

General Medicine · STAT News — Health Tech · 3d

Analgesic Efficacy of Celecoxib Versus Ibuprofen After Third Molar Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

No significant difference at 4-8 or 12-16 hours. At 24 hours, celecoxib had lower VAS scores (SMD −0.35; 95% CI −0.61 to −0.08; p=0.01), but TOPAR/TOTPAR showed no difference (SMD 0.36; 95% CI −0.00 to 0.73; p=0.05).

General Surgery · Cureus · 3d

Interra Health now supports CMS’ GLP-1 Bridge Program

If you prescribe GLP-1s, this platform flags patients who may qualify for the CMS Bridge Program, easing access and cost barriers.

Endocrinology · Fierce Healthcare · 3d

nPhase launches AI clinical data management platform to soup up sponsor trial design

If your site runs sponsored trials, AI-driven data management may shorten query resolution and speed the path from enrolment to published result.

Medicine · Fierce Biotech · 3d

Increases in healthcare spending the largest driver behind premium growth: Yale study

Understanding that spending—not insurer profit—drives premiums helps you advocate for cost-effective care and explain rising patient costs.

General Medicine · Fierce Healthcare · 3d

Extended Thromboprophylaxis With Rivaroxaban, Aspirin, or No Prophylaxis After Reverse Total Shoulder Arthroplasty: Practice Patterns and 90-Day Complications in a Single-Center Retrospective Cohort Study

Symptomatic PE: 1/28 (3.6%) no prophylaxis, 1/17 (5.9%) aspirin, 0/23 (0%) rivaroxaban; p=0.717, no pairwise comparison significant. No deep vein thrombosis occurred.

Orthopaedics · Cureus · 3d

With elderly population set to double by 2050, govt looks to step up healthcare, caregiving services

Expect more geriatric-focused services and referrals; plan for rising multimorbidity and caregiver support in your practice.

General Medicine · ETHealthworld · 3d

Lenacapavir-Based Salvage Therapy in Heavily Treatment-Experienced Multidrug-Resistant HIV-1: A Case Report From the United Arab Emirates

After virologic rebound in 2023 and failure of salvage regimens, lenacapavir with BIC/FTC/TAF in 2024 produced a rapid undetectable viral load, with suppression maintained to date.

General Medicine · Cureus · 3d

Distribution of gyrA, rrs, and eis Gene Mutations Associated With Second-Line Drug Resistance Among Multidrug-Resistant Mycobacterium tuberculosis Isolates

FQ resistance in 30 (35.3%) isolates, SLID resistance in 7 (8.2%). Commonest FQ mutation gyrA D94G (53.3%), then A90V (20.0%), D94N/Y (16.7%). rrs A1401G in 28.6% and G1484T in 14.3% of SLID-resistant isolates; no eis mutations.

General Medicine · Cureus · 3d

Comparison of Sequential Organ Failure Assessment (SOFA), Quick Sequential Organ Failure Assessment (qSOFA), Obstetrically Modified SOFA, and Obstetrically Modified qSOFA Scores for Predicting Maternal Outcomes in High-Risk Obstetric Patients

15 maternal deaths. SOFA AUC 0.97 (95% CI 0.94-0.99) at cutoff ≥10; omSOFA 0.93 (0.89-0.97) at ≥9; qSOFA 0.76 (0.68-0.84); omqSOFA 0.79 (0.71-0.87).

Obstetrics & Gynaecology · Cureus · 3d

Intrawound Vancomycin Powder Reduces Deep Surgical Site Infection in Tibial Plateau and Pilon Fractures: A Systematic Review and Meta-Analysis

Deep SSI fell with vancomycin powder (OR 0.53; 95% CI 0.35-0.80; p = 0.002; I² = 0%), infection rate 4.9% versus 9.7%. Gram-positive deep infections fell (OR 0.32; 95% CI 0.14-0.73; p = 0.007). Superficial SSI unchanged (OR 1.17; p = 0.66).

Orthopaedics · Cureus · 3d