Archive

Izalontamab brengitecan versus platinum-based chemotherapy in EGFR-mutated advanced non-squamous non-small-cell lung cancer after progression on third-generation EGFR tyrosine kinase inhibitors (PANKU-Lung01): a multicentre, randomised, open-label, phase 3 trial in China.

A bispecific EGFR-HER3 ADC beat platinum chemotherapy after third-generation TKI failure in EGFR-mutated NSCLC, offering a targeted option where chemotherapy is the current default.

Oncology · Lancet · 2d

First-line pembrolizumab versus carboplatin plus paclitaxel in participants with mismatch repair-deficient advanced or recurrent endometrial cancer (KEYNOTE-C93/GOG-3064/ENGOT-en15): interim analysis of a multicentre, open-label, randomised, active-comparator controlled, phase 3 trial.

If pembrolizumab beats carboplatin-paclitaxel on PFS in dMMR disease, your first-line choice for these patients shifts from chemo to checkpoint monotherapy.

Oncology · Lancet · 2d

Reversible Stress Cardiomyopathy and Suspected Neuroleptic Malignant Syndrome Following Clozapine Withdrawal: A Case Report

Severe left ventricular systolic impairment with apical akinesis and basal hypercontractility, elevated troponin, rising creatine kinase and new rigidity; all resolved with supportive care alone, without specific NMS treatment

Psychiatry · Cureus · 2d

First Description of Intermediate Component Separation: A Novel Compartment-Preserving Technique for Medium and Large Incisional Hernia Repair

A compartment-preserving mesh technique for medium-to-large incisional hernias may reduce dissection-related morbidity, but this is a first description without outcome data to guide adoption yet.

General Surgery · Cureus · 2d

Spontaneous Tumor Lysis Syndrome in a Critically Ill Patient With Cytology Favoring Small Cell Carcinoma: A Case Report

Uric acid rose to a documented peak of 12 mg/dL and LDH reached 3,608 U/L, with progressive hyperkalemia, hyperphosphatemia, hypocalcemia, acidosis and anuria; she died of refractory shock and multiorgan failure

Oncology · Cureus · 2d

Contemporary Management of Colorectal Liver Metastases

Resectability is no longer the sole gate: molecular profile and functional liver reserve now decide whether your CRLM patient goes straight to surgery or to conversion therapy first.

Oncology · Cureus · 2d

Concurrent Heparin-Induced and Valproate-Induced Thrombocytopenia Following Transcatheter Aortic Valve Replacement: A Diagnostic Challenge

After TAVR, a falling platelet count has two plausible culprits—heparin and valproate; confirm with serotonin release assay before assuming one, since dual DITP changes anticoagulation and sedation choices.

Cardiology · Cureus · 2d

One in four tribal adults in Odisha has impaired kidney function: ICMR study

A quarter of 19,703 tribal adults screened had impaired kidney function, so consider eGFR testing in Adivasi patients from these 14 districts rather than waiting for symptoms.

General Medicine · ETHealthworld · 2d

Artificial Intelligence-Supported Learning and Its Effect on Knowledge Acquisition and Practical Performance Among Nursing Students: A Systematic Review and Meta-Analysis

Knowledge findings were too inconsistent to pool: one study showed a very large benefit for a purpose-built chatbot, another showed no clear difference. No study assessed observed clinical performance; one general-purpose language model produced poorer rubric-scored work than textbook learning.

Medicine · Cureus · 2d

Non-prescription Antibiotic Dispensing in Community Pharmacies of Islamabad Capital Territory, Pakistan: A Simulated Client Study

Simulated clients were readily sold antibiotics without prescriptions in Islamabad, so assume patients arrive already partially treated and counsel on completing prescribed courses.

General Medicine · Cureus · 2d

When a Contaminant Is Not a Contaminant: A Case Report of Micrococcus luteus Causing Septic Shock in the Absence of Traditional Risk Factors

Multiple blood cultures grew M. luteus, confirming true bacteremia rather than contamination; she required fluid resuscitation, vasopressors and intravenous antibiotics, then improved with clearance of bacteremia.

General Medicine · Cureus · 2d

Patient- and Operator-Related Factors Associated With Difficult Lumbar Epidural Catheter Placement: A Retrospective Observational Study

Knowing which patient and operator factors predict needing two or more skin punctures lets you anticipate a difficult lumbar epidural and plan analgesia accordingly.

Anaesthesiology · Cureus · 2d

When a Burn Scar Invades the Brain: A Case Report of Advanced Marjolin Ulcer of the Scalp

Any non-healing ulcer on an old burn scar warrants biopsy, not dressing — this one eroded through scalp into brain 33 years after a childhood injury.

General Surgery · Cureus · 2d

Small Bowel Perforation and Subsequent Pleural Effusion Following Operative Hysteroscopy: A Case Report

Persistent abdominal pain and peritonism after hysteroscopy can signal bowel injury, not just uterine perforation — CT early, since stable vitals do not exclude it.

Obstetrics & Gynaecology · Cureus · 2d

Sex-Based Differences in Outcomes of Cardiac Resynchronization Therapy in Patients With Left Bundle Branch Block: A Systematic Review and Meta-Analysis

In LBBB-confined cohorts, women appear to gain more from CRT than men — worth weighing when you refer female HFrEF patients for device therapy.

Cardiology · Cureus · 2d

Clarithromycin-Associated Carbamazepine Toxicity Presenting as a Posterior Circulation Stroke Mimic

Serum carbamazepine was 18.6 mg/L and sodium 122 mmol/L, down from a baseline of approximately 130 mmol/L. Symptoms resolved within 48 hours of withholding carbamazepine and correcting hypovolaemia.

Neurology · Cureus · 2d

Troponin Elevation in Type 2 Myocardial Infarction: A Systematic Review on Who May Benefit From Coronary Evaluation

A raised troponin in T2MI does not tell you who needs angiography; this review frames which supply-demand patients may actually benefit from coronary evaluation.

Cardiology · Cureus · 2d

Reconstructive Strategies in Acute Nasal Soft-Tissue Trauma: A Narrative Review and Subunit-Based Algorithm

Gives you a subunit-based framework for timing and salvage decisions in acute nasal trauma, where contamination and tissue viability make oncologic algorithms unreliable.

General Surgery · Cureus · 2d

Invasive Infection Associated With Probiotics in Adults: Does the Pathogen Originate From the Product or the Host Intestine?

Before prescribing probiotics to ICU or immunocompromised patients, note that strain-level typing is needed to tell product-derived bacteremia from the patient's own flora.

General Medicine · Cureus · 2d

Pulmonary Embolism With Pulmonary Infarction Despite Low-Risk Prediction Scores: Atypical Pleuritic, Abdominal, and Shoulder Pain

PERC, Wells and Geneva scores all indicated low pretest probability despite CT angiography confirming subsegmental PE with pulmonary infarction; D-dimer was near-threshold

General Medicine · Cureus · 3d

Divarasib as Compared with Sotorasib or Adagrasib in KRAS G12C-Mutated NSCLC.

A next-generation KRAS G12C inhibitor beat sotorasib/adagrasib head-to-head in previously treated NSCLC — expect divarasib to enter your second-line sequencing decisions.

Oncology · NEJM · 3d

Sacituzumab Tirumotecan plus Pembrolizumab in PD-L1-Negative Advanced NSCLC.

If the combination beats pembrolizumab-chemotherapy in PD-L1-negative NSCLC, it offers a chemotherapy-sparing first-line option for a group with few good choices.

Oncology · NEJM · 3d

Osimertinib-Savolitinib in Advanced NSCLC after Progression during EGFR-TKI Therapy.

For EGFR-mutant NSCLC progressing on osimertinib, adding a MET inhibitor targets the commonest resistance mechanism — but requires confirming MET amplification or overexpression first.

Oncology · NEJM · 3d

Stratified Outpatient Management and Radiological Follow-Up After Endovascular Treatment for Unruptured Intracranial Aneurysms

A risk-stratified follow-up schedule after unruptured aneurysm coiling could cut routine imaging visits for stable patients while keeping closer watch on higher-risk anatomy.

Neurology · Cureus · 3d

Artificial Intelligence for the Verification of Nasogastric Tube Position in Chest Radiographs: A Systematic Review

If validated, AI triage of NGT position on chest films could cut the delay and missed malposition that make this a recurring patient-safety failure on wards.

Radiology · Cureus · 3d

Comparison of Acute Hematological Toxicities Between Three-Dimensional Conformal Radiotherapy (3DCRT) and Intensity-Modulated Radiotherapy (IMRT) in Locally Advanced Cervical Cancer

During EBRT, overall haematological toxicity was 97.14% with 3DCRT versus 77.14% with IMRT (p = 0.012); leukopenia 65% versus 34% (p = 0.05). After ICRT, overall toxicity 97.14% versus 71.43% (p = 0.006) and anaemia 85.7% versus 51.4% (p = 0.002).

Oncology · Cureus · 3d

Age- and Sex-Specific Distribution of Vascular and Behavioural Risk Factors Among Patients With Acute Ischaemic Stroke: A Hospital-Based Study From North India

Dyslipidaemia 56.2%, hypertension 55.4%, diabetes 55.1%. Hypertension and dyslipidaemia rose with age (both p<0.001). RHD was more common in females (15.0% vs 6.1%, p=0.010); combined CAD/RHD 50.3% vs 38.9% (p=0.044).

Neurology · Cureus · 3d

Comparison of Nifedipine Versus Nitroglycerin Patch in the Management of Preterm Labor: A Prospective Comparative Cohort Study

Supports oral nifedipine as first-line tocolysis, buying the 48 hours needed for steroids and referral without relying on a patch.

Obstetrics & Gynaecology · Cureus · 3d

Comparative Clinical Outcomes of Fractional CO₂ Laser-Assisted Topical Therapy for Nail Psoriasis: A Systematic Review

Direct comparative effects were inconsistent across studies and varied by topical agent, comparator and assessment time. Advantages appeared in selected tazarotene and methotrexate comparisons; other comparisons showed no clear incremental benefit. Meta-analysis was not possible due to heterogeneity.

General Medicine · Cureus · 3d

Visceral Leishmaniasis Presenting as Hemophagocytic Lymphohistiocytosis in a Non-endemic Setting: A Case Report

HLH features prompted anakinra and corticosteroids; VL was then confirmed by serology, PCR and histopathology, and liposomal amphotericin B produced rapid clinical improvement

General Medicine · Cureus · 3d

Marked QT Prolongation and Torsades de Pointes Following Pulsed Field Ablation for Persistent Atrial Fibrillation

After PFA in a low-EF patient on amiodarone, QT prolonged enough to cause torsades — check post-procedure ECGs and electrolytes in similar high-risk patients.

Cardiology · Cureus · 3d

Concordance Between Trial Efficacy and Real-World Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure With Reduced Ejection Fraction: A Systematic Review and Meta-Analysis

Confirms the HFrEF benefit you see in clinic mirrors trial event reductions, so SGLT2 inhibitors deserve routine use in eligible patients rather than cautious selective prescribing.

Cardiology · Cureus · 3d

Species Distribution and Antifungal Susceptibility of Candida Bloodstream Isolates in Children: A Three-Year Study From North India

Non-albicans Candida now dominates paediatric bloodstream infections here, so empiric antifungal choice in a sick neonate should follow local susceptibility, not albicans-era habits.

Paediatrics · Cureus · 3d

Small Bowel Obstruction Temporally Associated With an Unsupervised Transition From Tirzepatide to Semaglutide After a Prolonged Treatment Interruption: A Case Report

Ask patients on GLP-1 agonists who stopped and restarted, or switched agents, whether they re-titrated — resuming at a prior dose can precipitate obstruction.

Gastroenterology · Cureus · 4d

Anbenitamab plus HB1801 for HER2-Positive Advanced Breast Cancer.

A HER2 bispecific plus albumin-bound docetaxel may offer a first-line alternative to THP, but wait for the survival and toxicity data before switching regimens.

Oncology · NEJM · 4d

Durvalumab, Tremelimumab, and Enfortumab Vedotin in Muscle-Invasive Bladder Cancer.

If perioperative durvalumab plus neoadjuvant enfortumab vedotin improves outcomes in cisplatin-ineligible patients, it reshapes who you can offer bladder-sparing curative-intent therapy to.

Oncology · NEJM · 4d

Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 trial.

Five-year data confirm the fixed-dose relatlimab-nivolumab combination's durable survival benefit over nivolumab alone, supporting it as a first-line option in untreated advanced melanoma.

Oncology · Nature Medicine · 4d

Sodium-Glucose Cotransporter 2 Inhibitor Use and Levels of Hemoglobin, Markers of Iron Metabolism, and Erythropoiesis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Explains the small but consistent hemoglobin rise on SGLT2 inhibitors — useful when interpreting falling or stable counts in diabetic and heart-failure patients already on these drugs.

Endocrinology · JAMA · 4d

Neoadjuvant nivolumab with or without visugromab in muscle-invasive bladder cancer: the phase 2a GDFATHER-NEO trial.

Adds a GDF-15 antibody to neoadjuvant nivolumab in MIBC; check the pathological response and toxicity data before considering this combination for cisplatin-ineligible patients.

Oncology · Nature Medicine · 4d

14-day versus 28-day trifluridine-tipiracil plus bevacizumab for refractory metastatic colorectal cancer (PRABITAS): a pragmatic, multicentre, open-label, randomised, phase 3, non-inferiority trial in Japan.

If halving the FTD-TPI exposure days preserves survival, you can cut haematological and GI toxicity in heavily pretreated patients without sacrificing efficacy.

Oncology · Lancet · 4d