Archive

Early Laparoscopic Cholecystectomy for Acute Gallstone Pancreatitis: Retrospective Review of Factors Influencing Timing of Surgery and Outcomes in a Single Institution

83 (42%) met all three preoperative criteria, 116 (58%) did not. Median time to surgery 4 days (IQR 3-6), median length of stay 6 days (IQR 4-8), similar between groups. No significant difference in surgical site infection, haematoma, bile leak, or intra-abdominal collection.

General Surgery · Cureus · 16 Sept

The Bidirectional Relationship Between Rheumatoid Arthritis and Periodontitis: Current Evidence and Clinical Implications

No pooled effect estimates are reported. Evidence suggests periodontal infection amplifies systemic inflammation and autoimmune responses, while RA accelerates periodontal breakdown; periodontal therapy may improve selected RA activity measures, but consistency and clinical significance remain uncertain.

General Medicine · Cureus · 16 Sept

Melioidosis Presenting as a Solitary Liver Abscess With Culture-Negative Septic Arthritis: A Case Report

Liver abscess culture grew Burkholderia pseudomallei; knee aspirate had 35,000/mm³ leukocytes but negative culture. Ceftazidime gave improvement within 36-48 hours.

Gastroenterology · Cureus · 16 Sept

Radiologically Occult Bilateral Androgen-Secreting Sex Cord-Stromal Tumors in a Postmenopausal Woman

Imaging was negative, yet bilateral androgen-secreting sex cord-stromal tumours were found at bilateral salpingo-oophorectomy. These tumours are typically unilateral.

Obstetrics & Gynaecology · Cureus · 16 Sept

Liquid biopsy for early detection of pancreatic ductal adenocarcinoma.

A validated miRNA blood panel could flag early-stage pancreatic cancer before imaging, when resection is still possible.

Oncology · Nature Medicine · 16 Sept

Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial.

If adolescent hemophilia B patients sustain factor IX levels after one infusion, they may stop prophylactic injections through the highest-risk bleeding years.

Paediatrics · Nature Medicine · 16 Sept

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse.

Supports EBV-directed monitoring or antiviral strategies as a way to anticipate and possibly prevent MS relapses in your RRMS patients.

Neurology · Nature Medicine · 16 Sept

Sex-specific biological aging clocks across organs and omics.

Female and male clocks diverged markedly; sex-specific clocks predicted systemic disease and all-cause mortality in sex- and organ-dependent patterns, and brain clock tracked cognitive decline in preclinical AD

General Medicine · Nature Medicine · 16 Sept

Revascularization in Asymptomatic Carotid Artery Stenosis With Hemodynamic Impairment and Cognitive Outcomes: The CREST-H Substudy of the CREST-2 Randomized Clinical Trial.

No treatment difference in cognitive z score over 1 year: adjusted difference -0.15 SD (95% CI, -0.54 to 0.24). Treatment × hemodynamic interaction not significant (β=0.018; 95% CI, -0.025 to 0.061; P=.40)

Neurology · JAMA · 16 Sept

Short or Long Antibiotic Regimens in Orthopedics.

Definite treatment failure by 12 months: 14.1% (34/241) long-duration vs 11.1% (26/234) short-duration; risk difference -3.0 percentage points (95% CI -9.0 to 3.0), meeting noninferiority.

Orthopaedics · NEJM · 16 Sept

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.

No between-group difference in adjusted composite z score at 4 years: CAS trial 0.03 (95% CI, -0.09 to 0.15); CEA trial 0.02 (95% CI, -0.09 to 0.14). No individual test differed.

Neurology · JAMA · 16 Sept

Risk-guided cardioprotection in cardio-oncology.

Trials selecting patients by cancer type and treatment regimen show modest to no significant benefit on subclinical or clinical measures of cardiotoxicity; risk-guided selection is proposed but not yet tested

Cardiology · Nature cardiovascular research · 16 Sept

Ferry Health, agentic AI scheduling platform backed by a16z, launches from stealth

If AI agents book and reschedule visits directly, front-desk call volume and no-show rates could fall, but referral and follow-up workflows may need rework.

Medicine · Fierce Healthcare · 16 Sept

Prolonged Primary Cytomegalovirus Infection in an Immunocompetent Adult Successfully Treated With Valganciclovir

Fever and liver dysfunction persisted despite supportive care; after valganciclovir, she became afebrile within five days and laboratory abnormalities improved.

General Medicine · Cureus · 16 Sept

External Lumbar Drainage for Refractory Intracranial Hypertension in Acute Brain Injury: A Narrative Review and Case Series

In refractory ICP above 22 mmHg despite maximal therapy, ELD may lower pressure without decompressive craniectomy, but case selection and herniation risk remain unresolved.

Neurology · Cureus · 16 Sept

Sickle Cell Disease in Latin America and the Caribbean: Where the Care Cascade Breaks Down

The care cascade breaks at every step: screening panels often omit the disease, transcranial Doppler implementation is uneven, and hydroxyurea use proportions are not comparable because denominators differ.

Paediatrics · Cureus · 16 Sept

Case Report of a Complex Colovesical Fistula Associated With an Infected Artificial Urinary Sphincter: Radiological and Clinical Manifestations and Treatment Discussion

Delayed AUS cuff infection/erosion occurred seven months post-placement, accompanied by colovesical and colocolonic fistulas, leading to life-threatening infection requiring immediate complex surgical intervention.

Urology · Cureus · 16 Sept

Association of Serum Ferritin and Cytokine Profile With Severity of Acute Cholecystitis in Patients Undergoing Laparoscopic Cholecystectomy

Median ferritin rose from 146 ng/mL (Grade I) to 428 ng/mL (Grade III); IL-6 from 13.2 to 56.8 pg/mL; TNF-α from 10.8 to 39.5 pg/mL (all p<0.001). IL-6 correlated best (r=0.72).

General Surgery · Cureus · 15 Sept

Unicornuate Uterus With a Rudimentary Horn Adenomyoma, Ipsilateral Renal Agenesis, and Deep Infiltrating Endometriosis: A Case Report

MRI showed a unicornuate uterus with a non-communicating left rudimentary horn (ESHRE/ESGE U4a) almost fully occupied by a 6 cm adenomyoma, plus deep infiltrating endometriosis and an absent left kidney.

Obstetrics & Gynaecology · Cureus · 15 Sept

Routine Forearm Cast Splitting in Pediatric Patients Following Closed Reduction

Splitting every pediatric forearm cast may not reduce complications; this comparison helps you decide which children actually need it.

Orthopaedics · Cureus · 15 Sept

Low-Dose Radiation Therapy for Osteoarthritis: A Critical Review and Proposal for Integration Into Contemporary Care

Offers a noninvasive option for OA patients still symptomatic despite standard pharmacologic, injectable and surgical care, though evidence and access remain limited.

Orthopaedics · Cureus · 15 Sept

Triple Vector-Borne Co-infection During Pregnancy in the United Arab Emirates: A Case Report at 21 Weeks’ Gestation

Rapid diagnostic testing identified all three pathogens; antimalarial therapy plus supportive care led to complete clinical and laboratory recovery, with improved haemoglobin and platelet counts, normalised liver function and clearance of parasitaemia.

Obstetrics & Gynaecology · Cureus · 15 Sept

Delays, tech failures abound in CMS' WISeR AI prior auth pilot, documents show

If AI prior auth spreads to India, expect the same delays and denials; document your appeals now.

General Medicine · Fierce Healthcare · 15 Sept

Divergence Between Pain and Functional Recovery After Rotator Cuff Repair: A Prospective Comparative Analysis of Visual Analogue Scale, Constant-Murley Score, Disabilities of the Arm, Shoulder and Hand, and Shoulder Pain and Disability Index Scores

VAS improved 5.88 points, DASH 45.17, SPADI 41.55, but CMS only 6.80. VAS change correlated weakly with CMS (r = -0.34, p = 0.03) and DASH (r = 0.38, p = 0.01), and not with SPADI (r = 0.18, p = 0.27).

Orthopaedics · Cureus · 15 Sept

Sling reels in $123M series C to fund oral Tepezza rival through phase 3 trial

An oral alternative to IV Tepezza infusions could spare thyroid eye disease patients months of infusions if phase 3 confirms comparable efficacy.

Ophthalmology · Fierce Biotech · 15 Sept

Laryngeal vs. Esophageal Acid-Mediated Injury in Bulimia Nervosa: A Systematic Review

Laryngeal mucosa showed earlier and more severe pathological changes than esophageal mucosa in bulimia nervosa patients, attributed to lower acid-exposure tolerance, thinner epithelium, and reduced mucosal buffering capacity.

Gastroenterology · Cureus · 15 Sept

A Comparative Outcomes Study: Is Routine Hip Abduction Bracing Necessary After Gluteus Medius Repair?

Combined six-month complication and reoperation rate was 10 (11.6%) without bracing versus 9 (11.8%) with bracing; p=0.966. Reoperations 0% versus 2 (2.6%); p=0.219.

Orthopaedics · Cureus · 15 Sept

Acute Urinary Retention Leading to Post-renal Acute Kidney Injury Post-radiotherapy: A Case Report

Eight days post-radiotherapy, AUR with overflow incontinence and post-renal AKI; creatinine fell from 4.89 mg/dL to 1.46 mg/dL after Foley decompression. TURP later relieved catheter dependence.

Urology · Cureus · 15 Sept

Van Wyk-Grumbach Syndrome: A Rare Triad of Precocious Puberty, Pituitary Pseudomacroadenoma, and Multicystic Ovaries in an Eight-Year-Old Girl

Bone age was delayed to 3.5-4 years and thyroid profile confirmed autoimmune primary hypothyroidism; the patient was managed purely medically with cautious levothyroxine, avoiding surgery

Paediatrics · Cureus · 15 Sept

Most health systems deploy AI tools without formal IT approval. What are the risks?

Unvetted AI tools touching patient data bypass your hospital's security review, so ask whether the scribe or triage app you use was IT-approved.

Medicine · Fierce Healthcare · 15 Sept

Inflammatory Papillary Hyperplasia: A Diagnostic Challenge to Oral Physicians

Inflammatory papillary hyperplasia presented on the labial aspect of the edentulous mandibular anterior alveolar ridge, a rare site; palate is the usual location

Medicine · Cureus · 15 Sept

STAT+: Medicare to expand its pilot that pays for technology to manage chronic diseases

Expanded Medicare coverage of remote monitoring signals a coming reimbursement pathway for chronic-disease tech, worth watching if you run diabetes or hypertension clinics.

General Medicine · STAT News — Health Tech · 15 Sept

Smokeless Tobacco Pouch Keratosis: A Report of Two Cases

Both patients had thick whitish wrinkled lesions along the vestibule or gingiva at the site of smokeless tobacco contact; both received nicotine replacement therapy to quit.

Oncology · Cureus · 15 Sept

Demographic Factors Influencing the Need for Repeat Radiofrequency Ablation in Chronic Pain Management: A Retrospective Study

Race, sex, age and BMI may predict who needs repeat radiofrequency ablation, so you can counsel chronic pain patients on likely retreatment before the first procedure.

Anaesthesiology · Cureus · 15 Sept

Beyond Prognosis: A Systematic Review of the Neutrophil-to-Lymphocyte Ratio as a Modifiable Cardiovascular Biomarker

IL-6 inhibition gave the clearest dose-dependent NLR reduction; glutathione, cardiac rehabilitation, time-restricted eating, curcumin and hyperoxia also looked favourable. SGLT2 inhibitor results were inconsistent. Clinical outcomes were rarely reported and underpowered.

Cardiology · Cureus · 15 Sept

FDA Launches Expedited IND Pilot, Begins Accepting Applications

Faster IND clearance could shorten the wait before first-in-human trials of novel agents reach your patients.

Medicine · FDA — Press Announcements · 15 Sept

FDA launches pilot program to speed up sluggish phase 1 trials

Faster US phase 1 starts could bring novel drugs to your patients sooner, but early safety data may be thinner at first read.

Medicine · Fierce Biotech · 15 Sept

Assessing the Growing Impact of Oral GLP-1 Agonists on National Obesity Policies of the United Kingdom

No original data. The authors discuss access inequalities and state provision of oral GLP-1 receptor agonists, and argue these drugs should augment, not replace, established weight-management methods.

Endocrinology · Cureus · 15 Sept

STAT+: New documents reveal problems with Medicare’s prior-authorization pilot

If AI-driven prior authorization spreads, expect more denials and appeals paperwork for your Medicare patients' imaging, procedures and referrals.

General Medicine · STAT News — Health Tech · 15 Sept

Improving Engagement With Breast Cancer Screening Through Structured Telephone Outreach Among Uninsured Women

Of 361 patients, 110 (30.5%) were contacted; 70 (63.6%) accepted referral. Mammography completion was 2.9% at 30 days and 4.3% at 60 days; 74.3% of referred patients had no follow-through

Oncology · Cureus · 15 Sept