Archive

Spontaneous Pneumothorax During Stereotactic Body Radiotherapy for Pulmonary Metastasis From Osteosarcoma: A Case Report and Literature Review

Pneumothorax detected on routine image guidance after fraction four; patient remained clinically stable, treated with supplemental oxygen alone, and completed SBRT after brief interruption.

Oncology · Cureus · 17 Sept

Incidence of Osteoradionecrosis and Dental Implant Survival in Patients With Irradiated Head and Neck Malignancies: A Systematic Review and Meta-Analysis

Implants showed good overall survival with wide between-study variation; mandibular survival tended to exceed maxillary but was not statistically significant. ORN after implant placement was uncommon at patient and implant levels.

Oncology · Cureus · 17 Sept

Centre seeks NPPA report on high markups in hospital consumables

Markups up to 2,800% on consumables you implant and bill for may face trade-margin caps, changing what your hospital pays and charges.

Medicine · ETHealthworld · 17 Sept

Marked Increase in Influenza-Associated Acute Myositis Among Children During the 2024–2025 Season: A Two-Season Retrospective Cohort Study From Riyadh, Saudi Arabia

Influenza in children can cause acute myositis; a marked seasonal rise means consider it in any child with sudden calf pain and refusal to walk during flu season.

Paediatrics · Cureus · 17 Sept

Chylous Ascites: A Rare Chronic Case

Diuretics, dietary modification and repeated paracenteses failed to control recurrent symptomatic ascites; ascitic triglyceride testing supported chylous ascites, octreotide was started, and paracentesis frequency decreased.

Gastroenterology · Cureus · 17 Sept

Trends in Opioid Prescriptions Based on the Medical Information Mart for Intensive Care IV (MIMIC-IV) Database From 2008 to 2022

Patients receiving opioids fell from 46.5% (47,273 of 101,607) to 33.6% (16,545 of 49,173); prescriptions per patient fell from 9.9 to 5.8 and strength from 829 to 508 MME.

Anaesthesiology · Cureus · 17 Sept

Switch to injectable cabotegravir-rilpivirine given every 8 weeks in adolescents living with HIV with virological suppression in sub-Saharan Africa (LATA): a randomised, open-label, multicentre, 96-week non-inferiority trial.

Every-8-week injectable ART kept adolescents virologically suppressed as well as daily pills, offering an adherence-sparing option for a group with poor outcomes.

Paediatrics · Lancet · 17 Sept

Esophageal Cancer.

Five-year survival still under 20%, so recognise Barrett's and squamous risk factors early and refer promptly for endoscopy and multimodal therapy.

Oncology · NEJM · 17 Sept

Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy.

If maternal egg and peanut consumption prevents infant sensitisation, antenatal dietary advice shifts from avoidance to deliberate early allergen exposure.

Paediatrics · NEJM · 17 Sept

Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal.

5-year colorectal cancer incidence 0.77% with 5-year surveillance vs 0.82% with 3-year surveillance (difference -0.05 percentage points); upper 99.12% CI boundary 0.68, meeting noninferiority.

Gastroenterology · NEJM · 17 Sept

Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.

4-year event-free survival 83.0% (95% CI 77.4-87.4) with blinatumomab versus 70.3% (95% CI 63.8-75.9) with chemotherapy; hazard ratio 0.51 (95% CI 0.35-0.73).

Oncology · NEJM · 17 Sept

Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.

Mean pain score during IUD placement was 43.8 mm with mepivacaine versus 58.6 mm with placebo (mean difference, 14.8 mm [95% CI, 10.0-19.6]).

Obstetrics & Gynaecology · JAMA · 17 Sept

Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma.

Children with DMG on levetiracetam had longer overall survival; no such effect in hemispheric high-grade glioma. Levetiracetam reduced proliferation and tumour burden and extended survival in DMG xenograft mice only.

Oncology · Nature Medicine · 17 Sept

Gallium-68 (68Ga)-Labelled Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in the Initial Staging of High-Risk Prostatic Adenocarcinoma: Reclassification to Oligometastatic Disease and Change in Treatment Intent

PSMA PET identified a 15 mm left internal iliac node (SUL 6.9), 8 mm para-aortic node (SUL 3.2), and 6 mm costal lesion (SUL 1.4), reclassifying to miN1, miM1a, unifocal miM1b; PSA fell to 0.15 ng/mL at three months

Oncology · Cureus · 17 Sept

Chimeric Antigen Receptor T-cell (CAR-T) Therapy in Autoimmune Diseases: A Narrative Review

CAR-T is moving beyond oncology into refractory SLE, systemic sclerosis and vasculitis, so expect referrals for cell therapy in patients who have failed standard immunosuppression.

General Medicine · Cureus · 17 Sept

RAS Mutations as Prognostic Biomarkers in Digestive Cancers: From Binary Classification to Variant-Specific and Context-Dependent Risk Stratification

KRAS G12C tumours respond to KRAS G12C inhibitors; G12D/V versus G12R subtype and KRAS mutant dosage stratify outcomes in pancreatic cancer; RAS mutations predict anti-EGFR resistance in colorectal cancer.

Oncology · Cureus · 17 Sept

Sentara Health pilots GW RhythmX's AI precision care platform to support emerging primary care models

If AI risk stratification at the point of primary care proves out, it could change how chronic disease is triaged before specialists ever see the patient.

General Medicine · Fierce Healthcare · 17 Sept

Abnormally Low Hemoglobin A1c Due to a Heterozygous Alpha-Globin Variant (Hb I; HBA2 c.49A>G, p.Lys17Glu) in a Geriatric Patient

A heterozygous HBA2 variant, Hb I, caused a profoundly low HbA1c with no clinical phenotype; heterozygotes are clinically silent, so the only consequence is assay interference.

Endocrinology · Cureus · 17 Sept

Management of Advanced Tricompartmental Knee Osteoarthritis With Degenerative Meniscal Pathology Using Extracorporeal Magnetotransduction Therapy, Extracorporeal Shockwave Therapy, Microfragmented Adipose Tissue, and Platelet-Rich Plasma

NRS pain scores fell and KOOS pain, symptoms and quality-of-life domains improved after ESWT, EMTT and combined MFAT-PRP; no numerical values reported.

Orthopaedics · Cureus · 17 Sept

Not All Transverse Sinus Stenoses Behave the Same: Distinct Flow Phenotypes on Phase-Contrast MRI

Mean peak velocity was 16.97 cm/s proximal, 12.84 cm/s intra-stenotic and 14.82 cm/s distal. Ten segments (55.6%) were low-flow, seven (38.9%) jet, one (5.6%) intermediate.

Neurology · Cureus · 17 Sept

Microplastics in Human Ovarian Follicular Fluid and Female Fertility

Plastic-derived particles or polymer mass were detected in follicular fluid, but concentrations and polymer profiles differed substantially across analytical platforms; associations with lower fertilization rates, higher FSH, or diminished ovarian reserve were unreplicated.

Obstetrics & Gynaecology · Cureus · 16 Sept

Humana study links pharmacy care coordination to lower costs, fewer hospitalizations for cancer patients

Embedding specialty pharmacists in cancer care cut hospitalisations and ED visits, suggesting your oncology patients may benefit from coordinated pharmacy follow-up between cycles.

Oncology · Fierce Healthcare · 16 Sept

Bazex Syndrome as a Cutaneous Marker of Occult Malignancy: A Report of Two Cases

Both patients had oesophageal squamous cell carcinoma; one also had a synchronous large-cell neuroendocrine carcinoma. Skin biopsy showed nonspecific histopathological findings in both.

Oncology · Cureus · 16 Sept

Clinical Application and Safety of Intrathecal Adjuvants in Single-Shot Thoracic Segmental Spinal Anesthesia: A Narrative Review

Adjuvants significantly improve block quality, prolong analgesia, and reduce local anesthetic requirements. Fentanyl and dexmedetomidine are most studied; morphine, buprenorphine, and ketamine appear useful. Hypotension, bradycardia, and respiratory depression remain concerns.

Anaesthesiology · Cureus · 16 Sept

Tocilizumab in Acute Coronary Syndromes: A Systematic Review of Randomized Controlled Trials

Tocilizumab more than halved CRP area under the curve in three intravenous trials (all p < 0.001); one trial improved myocardial salvage index, but MACE and six-month clinical outcomes did not differ.

Cardiology · Cureus · 16 Sept

Myxoedema Coma With Type 2 Respiratory Failure and Hypothermia in an Oedematous Patient: A Case Report

Profound hypothyroidism confirmed (TSH 67 mU/L, T4 <2 pmol/L). She deteriorated with hypothermia, hypotension, bradypnea and reduced consciousness, requiring ICU and intubation, then improved on intravenous liothyronine and levothyroxine.

Endocrinology · Cureus · 16 Sept

Anterior Cruciate Ligament (ACL) Reconstruction With Lateral Meniscal Repair With and Without Lateral Extra-articular Tenodesis: A Prospective Comparative Study of Functional and Rotational Outcomes

Adding LET to ACL reconstruction with lateral meniscal repair may reduce residual rotational instability, so consider it in patients at high risk of graft failure.

Orthopaedics · Cureus · 16 Sept

Zileuton Beyond Asthma: A Multifaceted 5-Lipoxygenase Inhibitor With Emerging Therapeutic Potential Across Inflammation, Cancer, Neuroprotection, and Fibrosis

Zileuton's upstream 5-LOX blockade is being explored beyond asthma in cancer, fibrosis and neuroprotection, but evidence is still preclinical or early — not yet a reason to change prescribing.

General Medicine · Cureus · 16 Sept

Closed-Loop Neuroprosthetics: Advancing Long-Term Solutions for Brain-Level Function Restoration

No usable figures reported. Author attributes failure to reach clinical practice to material fatigue, electrode degradation, inflammation and electrical drift degrading sensing and stimulation over time.

Neurology · Cureus · 16 Sept

Minimally Invasive Coronary Artery Bypass Grafting (MICS-CABG) Versus Conventional Off-Pump Coronary Artery Bypass Grafting (OPCAB): A Single-Center Analysis of Early Outcomes and Institutional Experience

Ventilation was 8.80 ± 3.97 hours with MICS-CABG versus 4.22 ± 2.64 hours with OPCAB; chest drainage 887.0 ± 611.8 mL versus 328.9 ± 116.1 mL. No mortality or sternotomy conversion in either group.

Cardiology · Cureus · 16 Sept

Occupational Noise-Induced Hearing Loss in Indian Black Tea-Processing Factories: Assessing the Prevalence and Associated Factors of an Overlooked Problem

ONIHL prevalence was 28.8% (95% CI 24.1-34.1%). Highest in CTC room (44.8%), maintenance (37.5%), withering (28.2%), matching Leq,8h of 85.3, 85.1, 80.7 dBA. No worker wore hearing protection.

Medicine · Cureus · 16 Sept

Miniaturized Versus Standard-Tract Percutaneous Nephrolithotomy for Renal Calculi Larger Than 2 cm: Tract Caliber Determines Hemorrhagic Morbidity Without Compromising Stone Clearance

Stone-free rates similar (92% vs 93.9%; difference 1.9%; 95% CI -5.0 to 8.8). Mini-PCNL had smaller hemoglobin drop (0.95 vs 1.48 g/dL) and shorter stay (2.4 vs 3.1 days).

Urology · Cureus · 16 Sept

Oracle Health extends clinical AI agent to inpatient nurses

Voice-driven charting and auto-generated nursing summaries could cut the documentation time that eats into inpatient ward care, if your hospital runs Oracle Health.

Medicine · Fierce Healthcare · 16 Sept

Comparative Outcomes of Beta-Blockers vs Non-Dihydropyridine Calcium Channel Blockers in Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis

In HFpEF, beta-blockers and non-dihydropyridine calcium channel blockers show comparable outcomes, so choice can hinge on heart rate, exercise tolerance and tolerability rather than assumed superiority.

Cardiology · Cureus · 16 Sept

Theory of Artificial Intelligence Adaptation for Linguistic Concordance: Bridging Gaps in Patient-Centered Communication

AI translation could let you counsel patients in their own language, but this is theory only — no accuracy or safety data yet for clinical use.

General Medicine · Cureus · 16 Sept

Relapsing Polychondritis With Severe Airway Involvement Mimicking Refractory Asthma: A Diagnostic Challenge

Fixed airflow obstruction with minimal bronchodilator reversibility, inspiratory stridor, and progressive tracheobronchial thickening sparing the posterior membranous wall; symptoms persisted despite high-dose corticosteroids and cyclophosphamide.

General Medicine · Cureus · 16 Sept

Novartis ends ALS program after phase 2 flop, adding to R&D woes

Another negative ALS trial leaves your patients with no new disease-modifying option; enrolment in remaining ALS studies is now the only route to change that.

Neurology · Fierce Biotech · 16 Sept

Greener Surgery, Greener Hospital: Organizational Strategies for Carbon Footprint Reduction in Anesthesia and Perioperative Departments

No pooled effect size reported. Interventions such as reduced anesthetic-gas use, low-flow anesthesia, waste segregation, reusable equipment and energy conservation can lower environmental impact, but durability depended on leadership, accountability, audit and procurement alignment.

Anaesthesiology · Cureus · 16 Sept

Exacerbation of Pre-existing Hypothyroidism Following Enarodustat Administration in a Patient on Peritoneal Dialysis: A Case Report

If you prescribe enarodustat for renal anaemia, check thyroid function — it can worsen pre-existing hypothyroidism, as roxadustat does.

Endocrinology · Cureus · 16 Sept

The Mask of Delirium: Uncovering a Presumed Cardioembolic Stroke Through Comprehensive Clinical Evaluation

MRI confirmed acute left temporal restricted diffusion; troponin I was 1026.3 and 1060.5 ng/L, NT-proBNP 7451 pg/mL, and ejection fraction 15% to 20%.

Neurology · Cureus · 16 Sept