Archive

FDA clears Aptitude’s latest Metrix molecular dx to test for COVID

A faster, more sensitive COVID test could improve turnaround and detection in acute respiratory presentations, though Indian labs will need to validate availability and cost.

General Medicine · Fierce Biotech · 18 Sept

STAT+: A geriatrician explains why AI for older adults deserves careful scrutiny

Before trusting AI triage or risk scores in elderly patients, know that frailty, atypical presentation and multimorbidity can make model outputs misleading.

General Medicine · STAT News — Health Tech · 18 Sept

Underestimation of Low-Density Lipoprotein Cholesterol (LDL-C) Using the Friedewald Equation at Higher Triglyceride Levels: Evidence From a Method-Comparison Study

Mean bias rose to +20.2 mg/dL (-17.0 to 57.5) at TG 250-300 and +26.5 mg/dL (-17.7 to 70.6) above 300 mg/dL; 58.7% and 58.1% respectively were assigned to a lower LDL-C band.

Cardiology · Cureus · 18 Sept

Xenon pauses phase 3 depression trials after psychosis events

A novel antidepressant mechanism has now produced psychosis signals in phase 3, so weigh this risk before recommending any new non-monoaminergic agent to your patients.

Psychiatry · Fierce Biotech · 18 Sept

Efficacy of Medical Treatment Options for Reducing the Risk of Bleeding in Patients With Sporadic and Familial Cerebral Cavernous Malformations: A Systematic Review and Network Meta-Analysis

Statin vs no treatment: OR 0.32 (95% CI 0.14-0.73) for follow-up bleeding. Triple therapy vs none: OR 0.24 (0.06-0.95). Beta-blocker monotherapy vs antithrombotic: OR 2.41 (1.13-5.10).

Neurology · Cureus · 18 Sept

Procalcitonin-Guided Antimicrobial Therapy: Current Evidence for Clinical Decision-Making and Practical Limitations

PCT-guided therapy reduces antibiotic exposure without worsening major clinical outcomes when used to guide discontinuation; its role in guiding antibiotic initiation remains limited, particularly in sepsis.

General Medicine · Cureus · 18 Sept

BMS dumps $100M Orum degrader-antibody conjugate after glimpsing phase 1 data

A novel degrader-antibody conjugate failed early phase 1, a reminder that promising preclinical oncology platforms often do not translate into tolerable human activity.

Oncology · Fierce Biotech · 18 Sept

Beyond the Bowel: A Narrative Review Examining Bidirectional Mental Health Pathways Across Disorders of Gut-Brain Interaction and Inflammatory Bowel Disease

No primary numerical result reported. Longitudinal links between GI illness and psychiatric outcomes do not establish individual causation; many symptom-generating mechanisms rest mainly on preclinical evidence.

Gastroenterology · Cureus · 18 Sept

Iodine nutrition, thyroid function, and thyroid autoimmunity four decades after Universal Salt Iodisation in India: a cross-sectional study among schoolchildren (ICMR-SALT-T 1).

Four decades of salt iodisation may now be causing iodine excess and rising thyroid autoimmunity in Indian children, so consider this before attributing paediatric thyroid dysfunction to deficiency.

Endocrinology · Lancet regional health. Southeast Asia · 18 Sept

Epidemiology of Kyasanur forest disease in India, 2000-2025: a systematic review and meta-analysis.

KFD has spread beyond Karnataka; know the pooled positivity and case-fatality so you suspect it in febrile patients with tick exposure in new districts.

General Medicine · Lancet regional health. Southeast Asia · 18 Sept

Precision prevention and early detection: framework for a new clinical cancer control pathway.

Only 13% of cancers are found by screening and up to half present via emergency, so risk-stratified prevention and detection pathways could shift your patients to earlier-stage diagnosis.

Oncology · Lancet · 18 Sept

Empirical Antibiotic Therapy for the Management of Empyema Thoracis in Children: A Systematic Review.

Cloxacillin was empirical therapy in 10/17 studies (638 children), appropriate in six (419 children) as Staphylococcus aureus dominated. Third-generation cephalosporins used in 9/17 studies (444 children), appropriate in four (283 children).

Paediatrics · Indian pediatrics · 18 Sept

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation.

Among 75 year olds, expanded criteria donor/donation after circulatory death five year survival was 59% (51% to 66%) versus 55% (54% to 55%) on dialysis; hazard ratio 0.97 (0.70 to 1.33).

Urology · BMJ · 18 Sept

A universal visual foundation model for computational cytopathology.

CROWN achieved best overall performance among established pretrained encoders; accuracy exceeded 95% in 48 patch-level classification evaluations and 98% in 22 of them.

Oncology · Nature cancer · 18 Sept

Time to diagnosis of acute kidney injury and its predictors among outborn neonates in India: a competing-risk analysis of tele-ICU network data (2022-2024).

AKI occurred in 170 (29.8%); median time to diagnosis 2 days (IQR 1-5); five-day cumulative incidence 0.23 (95% CI 0.20-0.27). Dehydration, ventilation and vasopressors predicted early AKI.

Paediatrics · Lancet regional health. Southeast Asia · 18 Sept

Massive Early Post-Tracheostomy Hemorrhage From Inferior Thyroid Artery Branch Injury: An Oxygenation-Preserving Airway Rescue Strategy

Bleeding arose from inferior thyroid artery branches and required ligation and tracheostomy revision; oxygenation was maintained by digital compression while ventilating through the existing tracheostomy tube during video-laryngoscopic intubation.

Anaesthesiology · Cureus · 18 Sept

Postvoid Residual Urine as a Clue to the Diagnosis of Acute Bacterial Prostatitis: A Case Report

In a febrile man without perineal pain or prostatic tenderness, a raised postvoid residual may be the only pointer to acute bacterial prostatitis.

Urology · Cureus · 18 Sept

Sjögren’s Syndrome-Associated Medium- and Large-Vessel Vasculitis Presenting With Acute Abdominal Symptoms

CT angiography showed vasculitis of the superior mesenteric, inferior mesenteric, renal and left external iliac arteries; ANA strongly positive, anti-SSA, anti-SSB and Ro-52 positive, anti-dsDNA negative. Symptoms resolved rapidly on systemic corticosteroids.

Gastroenterology · Cureus · 18 Sept

Extensive Gastric Necrosis and Perforation Secondary to Intragastric Balloon-Related Gastric Outlet Obstruction: A Case Report

CT showed antropyloric balloon impaction, absent lesser-curvature mural enhancement and pneumoperitoneum. Laparotomy found extensive gastric necrosis with a 4-cm perforation; she died 72 hours postoperatively despite surgery.

Gastroenterology · Cureus · 18 Sept

Cervical Scrofula Revealing Miliary Tuberculosis and Previously Undiagnosed Advanced HIV: A Case Report

CD4 count 174 cells/mm³, HIV-1 RNA 956,000 copies/mL, positive QuantiFERON-TB Gold, BAL MTB PCR positive with rifampin resistance not detected.

General Medicine · Cureus · 18 Sept

FDA Approves First Gene Therapy for Pediatric Patients with Sanfilippo Syndrome Type A

First approved therapy for MPS IIIA, a fatal neurodegenerative lysosomal disorder; early diagnosis now becomes actionable rather than purely supportive.

Paediatrics · FDA — Press Announcements · 17 Sept

Bacteroides fragilis Empyema Secondary to Ruptured Pyogenic Liver Abscess: A Rare Cause of Septic Shock

CT showed a 9.05 × 4.37 cm collection behind the right hepatic lobe and right pleural effusion; ultrasound confirmed a 9.6 cm hepatic abscess. Pleural and abscess cultures both grew Bacteroides fragilis

Gastroenterology · Cureus · 17 Sept

An Alternative Approach to Adult One-Lung Ventilation Using a Standard Single-Lumen Endotracheal Tube

No quantitative outcomes reported; the abstract describes the technique and its indications only, with no ventilation, oxygenation or surgical data given.

Anaesthesiology · Cureus · 17 Sept

Prevalence and Severity of Hepatic Steatosis and Fibrosis Across Glycemic Categories Among Patients Attending a Tertiary Care Hospital: A FibroScan-Based Cross-Sectional Study

Severe steatosis (S3) in 2.4% nondiabetic, 6.9% prediabetic, 18.7% T2DM; adjusted aOR 2.22 (1.26-3.94) for prediabetes and 3.58 (1.58-8.14) for T2DM. Fibrosis distribution did not differ (p = 0.480).

Endocrinology · Cureus · 17 Sept

Physiotherapy Management of Computer Vision Syndrome and Associated Musculoskeletal Dysfunction in Young Adults: A Systematic Review of Evidence-Based Rehabilitation Approaches

For young patients with screen-related eye strain and neck or shoulder pain, the evidence supports combined ergonomic and postural physiotherapy rather than eye drops alone.

Ophthalmology · Cureus · 17 Sept

Beyond Pneumonia: A Case of Steroid-Responsive Pulmonary Eosinophilia With Atypical p-ANCA Positivity

When opacities persist on antibiotics, consider eosinophilic lung disease and trial steroids rather than escalating antimicrobials.

General Medicine · Cureus · 17 Sept

ARPA-H launches SPECTRA program, new autism research initiative

A US-funded push to standardise early autism risk detection and referral could shape the screening pathways and trial options you discuss with families.

Paediatrics · Fierce Biotech · 17 Sept

False-Negative Ligamentum Teres Tendon Sampling for the Detection of Systemic Amyloidosis

A negative ligamentum teres biopsy does not exclude transthyretin amyloidosis; sample ligamentum flavum or flexor tenosynovium instead when carpal tunnel and spinal stenosis coexist.

Orthopaedics · Cureus · 17 Sept

Sex Differences in Early Functional Outcomes After Acute Stroke: A Retrospective Cohort Study at a United Kingdom Tertiary Stroke Centre

Unadjusted, women had worse discharge mRS (common OR 1.34, 95% CI 1.10–1.64). After adjusting for age and pre-stroke mRS the association fell to 0.95 (95% CI 0.77–1.16) and fully adjusted 0.94 (0.76–1.16).

Neurology · Cureus · 17 Sept

Plasma Cystatin C as a Marker of Acute-on-Chronic Liver Failure and 28-Day Mortality in Patients With Acutely Decompensated Liver Cirrhosis: A Prospective Observational Study

Cystatin C may flag renal failure and 28-day death risk in decompensated cirrhosis better than creatinine, which overestimates GFR in these patients.

Gastroenterology · Cureus · 17 Sept

Improving Arterial Blood Gas Sampling Practice in the Emergency Department: A Two-Cycle Clinical Audit

Using venous gases to screen COPD exacerbations before arterial puncture can cut a painful, repeated invasive procedure in your emergency patients.

General Medicine · Cureus · 17 Sept

A Systematic Review and Meta-Analysis: Does Molecular Hydrogen Exert Radioprotective Effects Without Compromising the Antitumor Efficacy of Radiotherapy or Concurrent Chemoradiotherapy?

Tumour response was unchanged with molecular hydrogen versus control: RR 0.98 (95% CI 0.83-1.15); randomised trials only, RR 0.99 (95% CI 0.84-1.17). Narrative synthesis reported reduced radiation-induced toxicities.

Oncology · Cureus · 17 Sept

Trends in the Frequency of Severe Maternal Morbidity Among American Indian and Alaska Native Individuals at Two Major Hospitals in the East Valley, Arizona

AI/AN individuals had the highest cumulative SMM rate (4.12%; 64 cases among 1,554 deliveries), rising from 1.13% in 2020 to 6.17% in 2025 — the only group with a significant trend (0.848 percentage points per year; p = 0.0415).

Obstetrics & Gynaecology · Cureus · 17 Sept

Molecular Role of Carbohydrates in Acne and Seborrheic Dermatitis

In acne, high GI/GL plausibly drives hyperinsulinemia, IGF-1, mTORC1 activation and inflammation, but clinical dietary trials remain inconsistent. No direct dietary-glycemic evidence exists for seborrheic dermatitis.

Medicine · Cureus · 17 Sept

From Unexplained Iron-Deficiency Anaemia to Ileo-Ileal Intussusception: A Case Report of Primary Small Bowel Leiomyosarcoma

CT showed ileo-ileal intussusception; laparoscopic segmental small bowel resection found a spindle-cell leiomyosarcoma with mucosal ulceration. Anaemia resolved by two-month follow-up without transfusion; mild residual iron deficiency remained.

Gastroenterology · Cureus · 17 Sept

Spontaneous Retrobulbar Hematoma During a Hypertensive Crisis Managed Without Surgical Decompression: A Case Report

Visual acuity recovered to 10/10 (20/20), intraocular pressure fell to 18 mmHg, proptosis regressed and motility normalised after IV methylprednisolone and antihypertensives; hematoma resolved completely at four weeks.

Ophthalmology · Cureus · 17 Sept

Renal-Limited Thrombotic Microangiopathy Presenting as Acute on Chronic Kidney Failure in the Absence of Schistocytosis

Peripheral smear, autoimmune serologies and skin biopsy were unrevealing; only kidney biopsy showed TMA. She progressed to stage 5 CKD requiring peritoneal dialysis.

General Medicine · Cureus · 17 Sept

DPHARM: How to address the clinical trial enrollment crisis?

With 80% of trials missing enrollment targets, expect sponsors to push decentralised, site-light designs that shift screening and consent work onto your clinic.

Oncology · Fierce Biotech · 17 Sept

Kennedy appoints 8 new US Preventive Services Task Force members

USPSTF grades drive US screening and preventive coverage, so a reconstituted panel may shift recommendations Indian clinicians often follow.

General Medicine · Fierce Healthcare · 17 Sept

Cardiometabolic Risk Factors, Obesity Phenotypes, and Novel Anthropometric Indices in Patients With Acute Coronary Syndrome: A Hospital-Based Case-Control Study in Central India

BMI was not associated with ACS (Exp(B) 1.208, 95% CI 0.816-1.790, p=0.345). WHtR was (Exp(B) 2.473, 95% CI 1.638-3.732). MUO versus MHNW: OR 3.33, 95% CI 1.10-10.12.

Cardiology · Cureus · 17 Sept