Archive

Analysts ‘extremely bullish’ as Telix beams into Novartis’ territory with $1.6B ITM acquisition

Consolidation of radiopharma supply could affect availability and cost of lutetium-177 therapies you refer patients for, including neuroendocrine and prostate cancer.

Oncology · Fierce Biotech · 21 Sept

Bedside Flexible Cystoscopy-Guided First Suprapubic Catheter Exchange in a High-Risk Patient

Exchange completed without significant bleeding or other complications; direct visualization confirmed intravesical guidewire, catheter tip and balloon positioning, allowing immediate bleeding monitoring

Urology · Cureus · 21 Sept

Basilar Artery Occlusion Associated With Paradoxical Embolism After Traumatic Spinal Cord Injury: A Case Report

CT angiography showed partial distal basilar occlusion; mechanical thrombectomy by direct aspiration achieved complete reperfusion (TICI 3). Echocardiography showed right-to-left shunting with more than 30 microbubbles from the second cardiac cycle.

Neurology · Cureus · 21 Sept

Enhancing Inpatient Echocardiogram Request Appropriateness and Timeliness Using British Society of Echocardiography Guidelines: A Quality Improvement Project

Appropriate requests rose from 82/100 (82%) to 90/100 (90%), an absolute change of 8 percentage points (95% CI −1.7 to +17.8; p=0.153). Completion within 24 hours changed from 77/100 (77%) to 79/100 (79%).

Cardiology · Cureus · 21 Sept

Fornix Reconstruction in Cicatricial Ocular Surface Disease: A Narrative Review of Graft Materials, Surgical Techniques, and Medical Management

Graft choice and adjunctive medical therapy, not surgical technique alone, determine whether fornix depth holds after symblepharon release in severe cicatricial disease.

Ophthalmology · Cureus · 21 Sept

Association of Finerenone Dose and Estimated Glomerular Filtration Rate (eGFR) Slope Changes in Patients With Diabetic Kidney Disease: A Real-World Retrospective Study

Annual eGFR slope improved from -5.20 to +0.27 mL/min/1.73 m²/year (p = 0.0144). The 10 mg/day group improved from -7.11 to +3.35 (p = 0.00041); the 20 mg/day group did not (-3.29 to -2.85, p = 0.865).

Endocrinology · Cureus · 21 Sept

Cue chalks up phase 2 hives win for Xolair challenger

A second oral option for chronic spontaneous urticaria could help patients who fail or cannot tolerate omalizumab injections.

Medicine · Fierce Biotech · 21 Sept

Preventing Penile Retraction After Fournier’s Gangrene: Progressive-Tension Soft-Tissue Fixation for Penile Reconstruction

Progressive-tension fixation during grafting may prevent penile retraction and improve functional outcomes after extensive debridement for Fournier's gangrene.

Urology · Cureus · 21 Sept

Condition-Linked Opioid Prescribed-Medicine Events and Subsequent Emergency Department Use Among Adults With Surgical or Procedural Events: A Longitudinal Medical Expenditure Panel Survey Study

Adjusted mean annual ED visits 0.336 (95% CI 0.275-0.412) with versus 0.345 (95% CI 0.311-0.382) without a linked opioid event; mean ratio 0.975 (95% CI 0.784-1.211).

General Surgery · Cureus · 21 Sept

Understanding and targeting the tumour matrisome.

ECM accumulation tracks with tumour aggressiveness across cancers, so matrix-directed targets may offer a new axis beyond cytotoxic therapy.

Oncology · Nature reviews. Clinical oncology · 21 Sept

A consensus-based guideline for personalized bacteriophage therapy.

The guideline provides over 60 recommendations covering core principles, infrastructure, phage preparation and quality control, clinical administration, monitoring, documentation and future research priorities.

General Medicine · Nature Medicine · 21 Sept

Vaccines for Cancer: A Translational Science Review.

Sipuleucel-T reduced all-cause mortality in metastatic castrate-resistant prostate cancer (32% vs 23%; HR 0.78). Talimogene laherparepvec increased 6-month response in advanced melanoma (16.3% vs 2.1%). mRNA-4157 plus pembrolizumab improved relapse-free survival (76.6% vs 60%).

Oncology · JAMA · 21 Sept

Medicare Advantage Enrollment and Access to Kidney Transplant After the 21st Century Cures Act.

Transplant rates 2.51 vs 4.60 per 1000 person-months (aRR 0.71; 95% CI 0.69-0.72); wait-listing 3.05 vs 4.64 (aRR 0.77; 95% CI 0.75-0.78)

Urology · JAMA · 21 Sept

Severe Suspected Metformin-Associated Lactic Acidosis With Relatively Preserved Serum Creatinine at Presentation: Sequential Intermittent Hemodialysis and Continuous Venovenous Hemodialysis

Lactate was 24.1 mmol/L and peaked at 25.5 mmol/L, total CO2 <5 mmol/L, but creatinine only 1.18 mg/dL. Lactate declined from 25.5 to 16.0 mmol/L before dialysis; normalized after intermittent then continuous hemodialysis.

Endocrinology · Cureus · 21 Sept

Endovascular Thrombectomy in Patients With Cancer and Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Recanalization 77.1%, sICH 4.5%, mRS ≤2 in 26.8%, 90-day death 39.4%. Versus controls: mRS ≤2 RD -0.170 (95% CI -0.223 to -0.116); mortality RD 0.234 (95% CI 0.168 to 0.300).

Neurology · Cureus · 21 Sept

Antiphospholipid Syndrome as an Under-Recognized Cause of Ischemic Stroke in Older Adults: A Retrospective Case Series

Consider testing antiphospholipid antibodies in stroke patients over 65, not just the young—seven cases here suggest it is missed in older adults.

Neurology · Cureus · 21 Sept

A Small Dose With Large Movements: Suspected Gabapentin-Associated Mixed Hyperkinetic Movement Disorder in End-Stage Renal Disease: A Case Report

Involuntary jerking and truncal sway appeared after roughly one month of gabapentin; movements and altered affect resolved within approximately 48 hours of discontinuation

Neurology · Cureus · 20 Sept

HbA1C Variability as an Independent Predictor of Diabetic Retinopathy: A 10-Year Retrospective Nested Case-Control Study in a Middle Eastern Population

DR cases had higher HbA1c variability (median SD 1.00% vs 0.55%; CV 12.34% vs 7.93%, both p<0.001). Adjusted OR up to 13.85 per 1% SD increase; AUC 0.746.

Ophthalmology · Cureus · 20 Sept

Ocrelizumab Discontinuation After Recurrent Serious Infections in Clinically Stable Primary Progressive Multiple Sclerosis: A Case Report

In stable PPMS patients on long-term ocrelizumab, recurrent serious infections may justify stopping therapy even without disease activity — weigh infection risk against relapse risk as patients age.

Neurology · Cureus · 20 Sept

Beacon lights path to FDA approval with pivotal trial win for rare vision loss gene therapy

A one-time gene therapy improved visual acuity in X-linked retinitis pigmentosa, offering patients with this progressive, untreatable blindness a first potential disease-modifying option.

Ophthalmology · Fierce Biotech · 20 Sept

WHO flags growing health workforce gap as workers and patients age

A quarter of doctors retire within a decade while demand rises, so expect longer waits, heavier rosters and pressure to task-shift to nurses and community health workers.

General Medicine · ETHealthworld · 20 Sept

Lower Motor Neuron Disease Misclassified As Inflammatory Myopathy in a Young Woman With Myositis-Specific Antibodies

Despite creatine kinase normalisation on immunosuppression, weakness and wasting progressed; re-evaluation showed widespread fasciculations, neurogenic atrophy, and a lower-motor-neuron-predominant ALS phenotype.

Neurology · Cureus · 20 Sept

The Dangers of Chest Compression: A Case Report

Post-CPR sternal and rib fractures can seed infected parasternal collections; consider this in resuscitated patients with persistent chest pain or fever.

Cardiology · Cureus · 20 Sept

When Weakness Persists Beyond Its Apparent Cause: A Case Report of Myasthenia Gravis

In a patient with diarrhea and hypokalemia, weakness that persists after potassium correction should prompt consideration of myasthenia gravis rather than being attributed to the electrolyte deficit alone.

Neurology · Cureus · 20 Sept

Clinical Outcomes and Inflammatory Biomarker Changes After Intravenous Ketamine-Lidocaine Infusion in Refractory Neuropathic Pain: A Prospective Observational Pilot Study

Mean NRS fell from 7.93 ± 1.64 to 4.93 ± 2.23 immediately and 5.63 ± 2.58 at four weeks (p <0.001). At least 30% relief in 76.7% immediately and 53.3% at four weeks. IL-6 and CRP changes were not significant.

Anaesthesiology · Cureus · 20 Sept

Association Between Electronic Health Record Health Maintenance Topic and Lung Cancer Screening Completion in a Resident-Run Clinic

130 of 305 (43%) completed LDCT. The LCS topic was added in 96 of 130 (74%) screened versus 86 of 175 (49%) unscreened patients; association significant at p<0.001.

Oncology · Cureus · 20 Sept

Correlation Between Serum Ferritin and Electrocardiographic and Echocardiographic Markers of Cardiac Dysfunction in Children With Transfusion-Dependent β-Thalassemia Major

Ferritin negatively correlated with LVEF (r = -0.684), E/A ratio (r = -0.582), lateral e' (r = -0.658), TAPSE (r = -0.512); positively with E/Ea (r = 0.726), QTc (r = 0.648), MPI (r = 0.672), all p < 0.001.

Paediatrics · Cureus · 20 Sept

Growth Profile and Endocrine Dysfunction in Children Aged 2-10 Years With Transfusion-Dependent β-Thalassemia Major

78.7% had at least one endocrine abnormality; thyroid dysfunction 63.3%, vitamin D deficiency 62.0%, gonadal dysfunction 46.7%, cortisol abnormalities 41.3%, low growth hormone 38.7%.

Paediatrics · Cureus · 20 Sept

Phototherapy-Associated Changes in Ionized Calcium Among Neonates Born at ≥35 Weeks of Gestation

Neonates with iCa ≥1.40 mmol/L fell from 109/145 (75.2%) to 30/145 (20.7%) after 24 hours; among those without low baseline iCa, 33.1% developed <1.20 mmol/L.

Paediatrics · Cureus · 20 Sept

Myocarditis Revealing a Pathogenic Desmoplakin (DSP) Variant: Implications for Genetic Testing Pathways

In young myocarditis patients, especially with a family history, consider desmoplakin testing — a positive result reframes this as arrhythmogenic cardiomyopathy needing lifelong surveillance.

Cardiology · Cureus · 20 Sept

Impact of Obesity on Chemotherapy Pharmacokinetics, Toxicity, and Survival Outcomes in Pediatric Acute Lymphoblastic Leukemia

Obesity was linked to delayed high-dose methotrexate elimination, modestly reduced pegaspargase clearance, lower thioguanine nucleotide concentrations, more hepatotoxicity, pancreatitis, hyperbilirubinemia and vincristine neuropathy, and inferior survival in some cohorts.

Oncology · Cureus · 20 Sept

Structured Analgesia Pathways, Including Nurse-Initiated Approaches, for Acute Pain in Emergency Departments: A Systematic Review and Meta-Analysis

Meta-analysis supported a reduction in time to analgesia with structured pathways, but results varied considerably across studies; sensitivity analysis supported the same overall direction of effect.

Anaesthesiology · Cureus · 20 Sept

Not Everything Has a Single Diagnosis: A Case of Hematemesis, Pneumothorax, and Acute Pancreatitis Mimicking Boerhaave Syndrome

When hematemesis, pneumothorax and pancreatitis coexist, anchoring on one unifying diagnosis like Boerhaave can delay treating each separate, life-threatening problem.

Gastroenterology · Cureus · 20 Sept

Occult Incarcerated Osteochondral Fracture of the Medial Patellar Facet Following Acute Lateral Patellar Dislocation in an Adolescent: A Case Report

Surgical exploration found an incarcerated osteochondral fracture of the medial patellar facet, not an isolated MPFL injury; fixed with three headless compression screws plus suture anchor, with healing and return to activity.

Orthopaedics · Cureus · 20 Sept

Neurological and Functional Outcomes After Decompression With or Without Fusion for Thoracic Ossification of the Ligamentum Flavum: A Systematic Review and Evidence Synthesis

Ultrasonic osteotome reduced operative time, blood loss and dural tears versus high-speed burr, with no difference in long-term neurological outcomes. Dural ossification was the strongest predictor of CSF leakage.

Orthopaedics · Cureus · 20 Sept

Thyroid Eye Disease in the Teprotumumab Era: A Narrative Review of Expanding the Therapeutic Window Beyond Disease Activity

No primary numerical result reported. Review states emerging evidence supports clinically meaningful teprotumumab responses in longstanding and less-active disease, including delayed responses and retreatment, with variable durability and possible reactivation.

Ophthalmology · Cureus · 20 Sept

Evaluation of an AI-Assisted Virtual Fracture Clinic System: Common Referral Deficiencies and Outcomes Following Automated Feedback in a Major Trauma Centre

Automated checks on fracture-clinic referrals catch pathway and documentation errors before review, potentially cutting the extra clinical work deficient referrals create.

Orthopaedics · Cureus · 20 Sept

Frequency and Clinical Correlates of Sarcopenia in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

Sarcopenia prevalence 23.2% (64/276; 95% CI 18.6-28.5%). Significant fibrosis in 51.6% with sarcopenia versus 26.4% without; adjusted OR 2.03 (95% CI 1.10-3.77) after adjustment for age, sex, BMI, diabetes

Gastroenterology · Cureus · 19 Sept

Microbiological Profile of Pathogens Among Patients at a Tertiary Care Hospital in Mumbai, India

Gram-negatives were 1,627 (78.4%); E. coli 543 (26.2%), Klebsiella 519 (25.0%), Pseudomonas 328 (15.8%). MDROs 597 (28.8%), ESBL 369 (17.8%), MRSA 102 (4.9% of isolates; 77.3% of S. aureus).

General Medicine · Cureus · 19 Sept

Etanercept-Induced Cutaneous Necrotizing Vasculitis in a Patient With Rheumatoid Arthritis: A Case Report and Literature Review

After approximately 33 months of etanercept, bilateral petechial and purpuric lower-limb lesions appeared; biopsy showed fibrinoid necrosis of dermal vessels. Etanercept was stopped and lesions resolved completely within approximately 20 days.

General Medicine · Cureus · 19 Sept