Archive

Otsuka heads to FDA as Ionis-partnered ALS drug hits primary phase 3 endpoint

A positive phase 3 in ALS gives your patients a new disease-modifying option and a likely expedited FDA pathway to access it.

Neurology · Fierce Biotech · 22 Sept

Development and Preliminary Validation of the SHUDE Scoring System for Chronic Endometritis in Women With Previous Reproductive Failure Undergoing In Vitro Fertilization Treatment

A composite hysteroscopic score may standardise chronic endometritis diagnosis in IVF patients with prior reproductive failure, where single findings are unreliable.

Obstetrics & Gynaecology · Cureus · 22 Sept

Association of Helicobacter pylori Infection With the Severity of Psoriasis

Small study links H. pylori to worse psoriasis; testing and treating the infection may be worth considering in patients with severe, refractory disease.

Gastroenterology · Cureus · 22 Sept

Siemens Healthineers and Novo team up on fatty liver disease awareness, testing

Industry-backed imaging and pharma partnership may widen access to liver stiffness and steatosis assessment, helping you identify MASLD patients earlier before cirrhosis develops.

Gastroenterology · Fierce Biotech · 22 Sept

The Pivotal Role of Consultant Physicians in the Early Screening, Diagnosis, and Management of Osteopenia and Osteoporosis: An Expert Opinion

Roughly half of Indian adults have osteopenia, so screen opportunistically and treat before the first fragility fracture, not after it.

General Medicine · Cureus · 22 Sept

The Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio for Mortality in Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis

A cheap, routine CBC-derived NLR may help stratify mortality risk in IPF patients, guiding closer follow-up and earlier transplant referral without extra cost.

General Medicine · Cureus · 22 Sept

Ectopic Thyroid Tissue Mimicking a Thyroglossal Duct Cyst in a Child: A Diagnostic Pitfall Leading to Postoperative Hypothyroidism

Image the neck before excising a presumed thyroglossal duct cyst in a child — ectopic tissue may be the only thyroid, and removal causes permanent hypothyroidism.

Paediatrics · Cureus · 22 Sept

Cordis’ sirolimus drug-coated balloon earns FDA approval as a breakthrough device

A sirolimus-coated balloon now offers an alternative to repeat stenting for coronary in-stent restenosis, though Indian access and cost remain uncertain.

Cardiology · Fierce Biotech · 22 Sept

Critical Tracheal Compression by a Double Aortic Arch in a Young Infant: A Case Report

In a stridulous infant, consider a vascular ring before labelling it congenital airway disease; the ring is surgically correctable and imaging confirms it.

Paediatrics · Cureus · 22 Sept

Less Invasive Surfactant Administration Compared With Intubation-Surfactant-Extubation (INSURE), Nebulised Surfactant, and Continuous Positive Airway Pressure (CPAP) Alone in Preterm Infants With Respiratory Distress Syndrome: A Systematic Review

Versus CPAP alone, MIST halved intubation within 72 hours (36.5% vs 72.1%; RR 0.50, 95% CI 0.40-0.64; high certainty) and reduced pneumothorax. BPD among survivors fell (0.83, 0.70-0.98); death or BPD did not (0.87, 0.74-1.03).

Paediatrics · Cureus · 22 Sept

Diagnosis-Related Group Payment Systems and Hospital Efficiency, Quality, and Coding Behavior: A Systematic Review and Narrative Synthesis

DRG payment shifts hospitals toward efficiency but can drive upcoding and skimping on care; expect pressure on your documentation and discharge coding.

General Medicine · Cureus · 22 Sept

Renin-Angiotensin System (RAS) Inhibitors in High-Risk Patients With Type 2 Diabetes and Cardio-Renal Risk

Despite clear guideline backing, many high-risk T2D patients with cardio-renal risk are not on RAS inhibitors — check your own CKD and albuminuria patients.

Endocrinology · Cureus · 22 Sept

Infantile-Onset Pompe Disease: Current Therapeutic Landscape, Clinical Challenges, and Future Horizons

No trial data reported. Conventional enzyme replacement therapy improves cardiac function, motor development and survival, but is limited by lifelong intravenous infusions, immune responses and poor blood-brain barrier passage.

Paediatrics · Cureus · 22 Sept

Histopathology Versus Imaging: A Comparative Study of Liver Biopsy, Ultrasonography, and Triphasic Computed Tomography in Paediatric Patients With Chronic Liver Disease

In children with chronic liver disease, ultrasound and triphasic CT correlate imperfectly with biopsy, so imaging alone may understage fibrosis and delay referral.

Paediatrics · Cureus · 22 Sept

Sarcopenia in Chronic Obstructive Pulmonary Disease: Prevalence and Association With Disease Severity in an Indian Tertiary Care Cohort

Sarcopenia tracks with COPD severity in Indian patients, so screen muscle mass and strength in your COPD follow-ups, not just spirometry.

General Medicine · Cureus · 22 Sept

‘No Drain’ Strategy for Post-operative Orthopaedic Cases

Omitting closed-suction drains after orthopaedic surgery may cut transfusion needs, infection risk and hospital stay without raising hematoma or seroma rates.

Orthopaedics · Cureus · 22 Sept

Severe Pulmonary Hypertension in Critically Ill Children: A 10-Year Single-Center Case Series and Practical Management Considerations

All four presented with respiratory distress, hypoxaemia and cardiovascular compromise after recent respiratory infection. Median PICU stay 15 days (range 10-24). Two survived to discharge; two died of refractory pulmonary hypertensive crises.

Paediatrics · Cureus · 22 Sept

Flexible Laryngoscopy in Unexplained Cough: Institutional Outcomes and Community Practice Patterns

Before referring unexplained chronic cough, note that community practice patterns vary widely and laryngoscopy yield in this series may not justify routine early use.

General Medicine · Cureus · 22 Sept

Laminar Airflow vs. Conventional High-Efficiency Particulate Air (HEPA)-Filtered Ventilation in Primary Total Hip and Knee Arthroplasty: A Retrospective Comparative Cohort Study of 1,425 Patients

In 1,425 hip and knee arthroplasties, LAF showed no clear SSI advantage over conventional HEPA ventilation, so the costlier OR airflow system may not be justified.

Orthopaedics · Cureus · 22 Sept

Traumatic Macroglossia Associated With Clustered Epileptic Seizures in a Patient With Down Syndrome

In drug-resistant epilepsy with seizure clusters, tongue biting can cause macroglossia and acute airway obstruction; watch for tongue swelling after clustered tonic seizures.

Neurology · Cureus · 22 Sept

Anaconda Biomed snares $56M in funding for endovascular tech

Funds a pivotal trial of a next-gen aspiration catheter for large-vessel stroke thrombectomy, which may improve clot retrieval when current devices fail.

Neurology · Fierce Biotech · 22 Sept

Roche’s GLP-1/GIP drug hits in phase 2 diabetes trial, fueling best-in-disease hopes

Another dual GLP-1/GIP agonist reaching phase 2 endpoints expands the obesity-diabetes drug class your patients already ask about, though no head-to-head data yet.

Endocrinology · Fierce Biotech · 22 Sept

Hospitals told to step up monitoring, reporting of 'adverse events' related to medical devices

IPC's new guidance makes device-related adverse events a reportable hospital duty, so you should know your institution's reporting pathway for faulty devices.

Medicine · ETHealthworld · 22 Sept

Med device rules may get tougher: Govt plans new powers to stop manufacture, sale of unsafe, defective and spurious products, order destruction

Stronger recall and seizure powers mean devices you implant or prescribe could be pulled faster, so check batch notices and report suspected defects promptly.

Medicine · ETHealthworld · 22 Sept

Murine Typhus Masquerading as Thrombotic Thrombocytopenic Purpura in a Patient With Newly Diagnosed HIV

In febrile thrombocytopenia with renal failure, consider murine typhus before labelling TTP; doxycycline is curative and plasma exchange is not.

General Medicine · Cureus · 22 Sept

Glycyrrhizin-Induced Pseudoaldosteronism Contributing to Decompensated Heart Failure With Preserved Ejection Fraction

Ask heart failure patients about licorice and kampo preparations; stopping the culprit corrects hypokalemia and hypertension without diuretic escalation.

Cardiology · Cureus · 22 Sept

Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease.

ASGR1 may be the mediator between smoking and coronary disease, hinting at a target for risk stratification in smokers beyond standard risk factors.

Cardiology · Nature cardiovascular research · 22 Sept

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial.

Adds HER2 blockade to first-line chemoimmunotherapy for HER2-positive biliary tract cancer; check HER2 status at diagnosis since this subset now has a targeted option.

Oncology · Nature Medicine · 22 Sept

Bioadaptive spatiotemporal nanomedicine promotes metabolic recovery after myocardial infarction through NAD(+) and UCP2 regulation.

Preclinical only: staged NAD+ release restored mitochondrial metabolism and limited remodeling in mice, so watch for human dosing and delivery data before it touches post-MI care.

Cardiology · Nature cardiovascular research · 22 Sept

Blood proteomics of menopause map to brain aging and dementia risk.

Menopause-linked blood proteins track with brain aging, suggesting a window to counsel and monitor women for later dementia risk.

Obstetrics & Gynaecology · Nature Medicine · 22 Sept

Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis.

Blood-based multicancer screening added to usual care did not reduce late-stage cancer diagnoses, so it should not be offered as a routine screen yet.

Oncology · NEJM · 22 Sept

Peripheral arterial disease: adverse impacts, disparities in outcomes, and the path ahead.

PAD affects over 300 million people worldwide, causing chronic pain, functional limitation, amputation, myocardial infarction, stroke and death, with burden concentrated in underserved groups.

Cardiology · Lancet · 22 Sept

Tobacco Use Treatment: Synopsis of the 2026 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.

32 recommendations across 10 topic areas. Strong recommendations: motivational interviewing, FDA-approved pharmacotherapies, varenicline over other monotherapy, combination NRT over NRT monotherapy. Bupropion SR beyond 12 weeks was weak.

General Medicine · Annals · 22 Sept

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study.

Cancer detection rate 0.54% (95% CI 0.47-0.63%); PPV 60.3%; NPV 99.2%; specificity 99.64%; episode sensitivity 39.3% all cancers, 69.8% in prespecified 12-cancer subgroup; number needed to screen 185.

Oncology · Nature Medicine · 22 Sept

Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial.

Primary endpoint of reduced stage III/IV cancer incidence was not met. Positive predictive value fell from 58.0% to 45.8% across rounds; episode sensitivity 26.7-37.2% for all cancers, 47.6-63.4% for 12 prespecified types.

Oncology · Nature Medicine · 22 Sept

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

MsrA deletion impaired adipose browning, mitigated cachexia and prolonged survival of tumour-bearing mice. Iron-bound MSRA dimers promote browning by maintaining reduced protein kinase A catalytic subunit.

Oncology · Nature cancer · 22 Sept

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence.

In external testing (8 centres, n=11,466), specificity was 98.5%, sensitivity 90.0% for cancer and 52.5% for precancerous lesions. Real-world low-dose screening (n=10,959) reached 99.94% specificity.

Oncology · Nature Medicine · 22 Sept

Current advancements in the care of peripheral arterial disease: modern approaches to medical, endovascular, and surgical treatment.

Amputation risk is low in asymptomatic PAD and intermittent claudication, with only a few progressing to chronic limb threatening ischaemia; supervised exercise improves walking capacity and avoids revascularisation risks

Cardiology · Lancet · 22 Sept

Emergency Management of Obstructing Ureteric Stones: A Closed-Loop Audit of Hot Ureteroscopy Uptake Against Getting It Right First Time (GIRFT) Standards

Audit your own emergency stone pathway: same-admission ureteroscopy avoids a stent and a second procedure, so defaulting to stenting costs patients an extra anaesthetic.

Urology · Cureus · 22 Sept

Spontaneous Mesenteric Hematoma Following Severe Coughing in a Patient on Dual Antiplatelet Therapy: A Case Report

On dual antiplatelet therapy, acute abdominal pain can be a spontaneous mesenteric hematoma, not a surgical abdomen; CT before the knife.

General Surgery · Cureus · 22 Sept