Archive

AI-enabled Pelago expands from SUD care to mental health, behavioral addictions

A single AI-supported plan now covers substance use, mental health and behavioral addictions like gambling and binge eating, so you can refer co-occurring cases to one service instead of several.

Psychiatry · Fierce Healthcare · 23 Sept

QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials.

Most antidepressants raise QTc only modestly in the first eight weeks, but the signal varies by drug, so check baseline ECG in patients with cardiac risk factors.

Psychiatry · BMJ · 23 Sept

Contemporary menopausal hormone therapy and thrombotic disease: nationwide nested case-control study.

Quantifies VTE, stroke and MI risk by hormone type and route, so you can counsel women on transdermal versus oral preparations with contemporary numbers.

Obstetrics & Gynaecology · BMJ · 23 Sept

Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial.

If bridging tenecteplase improves outcomes in late-presenting basilar occlusion, it changes your thrombolysis decision for posterior-circulation strokes beyond the 4.5-hour window.

Neurology · JAMA · 23 Sept

AI-based characterization of Alzheimer's disease phenotypes from population-scale single-cell data.

Explains why Alzheimer's patients differ in psychosis and cognitive decline, pointing toward phenotype-specific targets rather than one-size-fits-all treatment.

Neurology · Nature Medicine · 23 Sept

Persistence of mucosal CAR-T cells and inflammatory remodeling in enterocolitis associated with BCMA CAR-T cell therapy.

If your myeloma patient on cilta-cel develops severe diarrhoea, mucosal CAR-T persistence and inflammatory remodelling suggest this is a distinct, durable enterocolitis needing its own management.

Oncology · Nature Medicine · 23 Sept

Vascular aging as a driver of organ dysfunction and systemic aging.

No primary outcome or effect size reported. Authors argue endothelial and mural cells instruct organ function via angiocrine and paracrine signalling, making microvascular aging a driver rather than a bystander.

Cardiology · Nature cardiovascular research · 23 Sept

New procurement guide for hospitals, payers takes aim at AI's environmental impact

If your hospital buys AI tools, this guide gives procurement criteria for vendors' energy and water use, an issue that may enter tenders you help specify.

Medicine · Fierce Healthcare · 23 Sept

Oracle deepens life sciences push with AI agents, real-world data analytics

If trial and real-world data queries get faster, evidence you rely on for treatment decisions may arrive sooner, though vendor claims need independent validation.

Medicine · Fierce Healthcare · 23 Sept

Fulminant Ischemic Colitis With Toxic Megacolon in a Young Man Receiving Testosterone Replacement Therapy Despite Therapeutic Phlebotomy for Hereditary Hemochromatosis: A Case Report

In young men on testosterone, consider drug-induced erythrocytosis and hypoperfusion as drivers of ischemic colitis, even when phlebotomy is ongoing.

Gastroenterology · Cureus · 23 Sept

Heidi lands $340M to build 'AI care partner' for clinicians

If ambient AI scribing expands into ordering and referrals, it could cut your documentation hours, but you should check who audits the agent's clinical decisions.

Medicine · Fierce Healthcare · 23 Sept

Postpartum Stroke: The Importance of Early Recognition and Multidisciplinary Management

MRI confirmed acute ischaemic infarction of the right basal ganglia and subcortical right frontal lobe; CT angiography and MRV showed no large-vessel occlusion or cerebral venous sinus thrombosis

Obstetrics & Gynaecology · Cureus · 23 Sept

Graves’ Disease and the Heart: Severe Reversible Left Ventricular Systolic Dysfunction With Apical Thrombus in a Young Woman With Relapsed Thyrotoxicosis

In young thyrotoxic patients with unexplained LV dysfunction, consider Graves' cardiomyopathy with apical thrombus — antithyroid therapy plus anticoagulation can fully reverse it.

Cardiology · Cureus · 23 Sept

Topical Carbonic Anhydrase Inhibitors in Macular Edema: A Systematic Review

Topical CAIs offer a non-invasive adjunct for macular edema, but this review's heterogeneous evidence means you should not yet substitute them for intravitreal therapy.

Ophthalmology · Cureus · 23 Sept

Impact of Premorbid Function and Comorbidities in Geriatric Traumatic Brain Injury Patients: A Systematic Review

In TBI patients over 60, baseline frailty and comorbidity predict mortality and recovery better than age alone, so weigh premorbid function when discussing prognosis and goals of care.

Neurology · Cureus · 23 Sept

Utility of Artificial Intelligence in Detecting Lymph Node Metastasis in Oral Cancer: A Systematic Review

AI models may flag occult nodal disease that conventional imaging misses in OSCC, potentially sparing some patients unnecessary neck dissection while catching others earlier.

Oncology · Cureus · 22 Sept

Clinical Outcomes of Percutaneous Full-Endoscopic Interlaminar Lumbar Discectomy (PFEILD): A Retrospective Single-Surgeon Pilot Cohort Study

Adds single-surgeon pilot data on percutaneous endoscopic interlaminar discectomy, supporting it as a minimally invasive option for selected lumbar disc herniation when conservative care fails.

Orthopaedics · Cureus · 22 Sept

Kidney Outcomes in Structural Heart and Cardiac Surgical Trials: The Case for Longitudinal Endpoint Reporting

Cardiac trial reports you rely on often omit longitudinal kidney outcomes, so post-procedure renal risk in your valve and surgical patients stays under-recognised.

Cardiology · Cureus · 22 Sept

Diagnosis, Treatment, and Current Controversies in Multiligament Knee Injuries: A Narrative Review

Single-stage anatomic reconstruction within two to three weeks is associated with less secondary meniscal and chondral injury. Functional outcomes deteriorate from seven years onward, with post-traumatic osteoarthritis in up to 71.7% of patients in some series.

Orthopaedics · Cureus · 22 Sept

Comparison of 25 µg Vaginal Misoprostol Versus Dinoprostone Gel for Induction of Labor in Term Prelabor Rupture of Membranes: A Retrospective Record-Based Observational Study

Induction-to-delivery 11.81 ± 3.06 vs 13.78 ± 3.99 hours (p < 0.001); oxytocin augmentation 16 (16.0%) vs 46 (46.0%) (p < 0.001); vaginal delivery within 24 hours 92 (92.0%) vs 94 (94.0%) (p = 0.780).

Obstetrics & Gynaecology · Cureus · 22 Sept

CD10-Positive Extranodal Marginal Zone Lymphoma of the Thyroid Arising in Hashimoto’s Thyroiditis: A Rare Diagnostic Challenge

In Hashimoto's patients with an FDG-avid thyroid nodule, consider marginal zone lymphoma and biopsy rather than assuming benign thyroiditis.

Endocrinology · Cureus · 22 Sept

Comparative Evaluation of the Vasodilatory Effects of Desflurane, Isoflurane, and Sevoflurane Using Perfusion Index During General Anaesthesia

Perfusion index on your existing pulse oximeter can track peripheral vasodilation differences between desflurane, isoflurane and sevoflurane without extra monitoring.

Anaesthesiology · Cureus · 22 Sept

Effects of Tirzepatide on Pancreatic β-Cell Function in Adults With Type 2 Diabetes Mellitus: A Systematic Review

Evidence that tirzepatide may preserve β-cell function, not just lower glucose, could shift when you start dual GIP/GLP-1 therapy in T2DM.

Endocrinology · Cureus · 22 Sept

Intramedullary Spinal Cord Metastasis From Oligometastatic Melanoma of Unknown Primary Treated With Stereotactic Body Radiotherapy

SBRT can control intramedullary cord metastases without surgery, so consider radiotherapy referral for oligometastatic melanoma patients with cord lesions and progressive myelopathy.

Oncology · Cureus · 22 Sept

Radiological Correlates of Headache and Papilledema in Patients Undergoing Cranial MRI: Clinical Relevance of the Evans Index and Fazekas Score

Incidental ventriculomegaly or white-matter changes on MRI may not explain your patient's headache or papilledema, so don't anchor the workup on these scores alone.

Neurology · Cureus · 22 Sept

American Medical Association urges CMS to stick to 2027 electronic PA deadline, enforcement

Electronic prior auth could cut the paperwork delays that stall your approvals, but only if CMS holds payers to the 2027 deadline.

Medicine · Fierce Healthcare · 22 Sept

STAT+: Epic’s mortality model, and Omada’s future products

Epic's mortality algorithm shapes which elderly patients get flagged for goals-of-care talks, so know its limits before trusting its score at the bedside.

General Medicine · STAT News — Health Tech · 22 Sept

Reliability and Validity of the Neonatal Pain, Agitation, and Sedation Scale in Mechanically Ventilated Neonates: A Systematic Review

N-PASS shows acceptable reliability and validity for titrating sedation in ventilated neonates, giving NICU teams a structured score where pain cannot be self-reported.

Paediatrics · Cureus · 22 Sept

Stereotactic Radiosurgery for an Unresectable Jugulotympanic Paraganglioma: Clinical Response and Acute Toxicity in a 70-Year-Old Patient

In elderly patients with unresectable skull-base paraganglioma, radiosurgery can control a slow-growing tumour while sparing nearby cranial nerves.

Oncology · Cureus · 22 Sept

Primary Glomus Tumor of the Inferior Vena Cava Diagnosed by Endovascular Biopsy: A Rare Incidental Finding

Imaging showed a 1.7-cm infrarenal IVC intraluminal abnormality; PET-CT showed no FDG-avid malignancy. Biopsy showed glomus tumor, later resected at 2.5 cm with Ki-67 <1%.

General Surgery · Cureus · 22 Sept

Occurrence of Heart Failure-Related Clinical Signs in a Japanese Convalescent Rehabilitation Ward: A Cross-Sectional Pilot Study

HF signs are common in rehab inpatients and often missed; screen for them before attributing breathlessness or fatigue to deconditioning.

Cardiology · Cureus · 22 Sept

Mode of Delivery and Perinatal Outcomes in Pregnancies With Absent End-Diastolic Flow: A Prospective Observational Study

In AEDF pregnancies beyond 28 weeks, this observational data on mode of delivery helps you weigh cesarean against vaginal birth when placental insufficiency is already advanced.

Obstetrics & Gynaecology · Cureus · 22 Sept

Blood test may help detect pancreatic cancer in earliest stages: Researchers

A sensitive stage 1-2 pancreatic cancer blood test could finally enable screening in high-risk patients, where CA19-9 and imaging currently miss early disease.

Oncology · ETHealthworld · 22 Sept

A Gallstone Masquerading as Hepatic Decompensation: A Case of Bouveret Syndrome

In cirrhotic patients with jaundice and distension, consider Bouveret syndrome: a migrated gallstone obstructing the pylorus can mimic hepatic decompensation and needs imaging, not just diuretics.

Gastroenterology · Cureus · 22 Sept

Celldex monoclonal antibody rebounds with pair of phase 3 wins for chronic skin condition

For patients with antihistamine-refractory chronic spontaneous urticaria, a KIT-targeting antibody now has phase 3 support, offering an alternative to omalizumab failures.

Medicine · Fierce Biotech · 22 Sept

Amgen’s Horizon-acquired fusion protein eases Sjögren's severity in ph. 3 win

If approved, dazodalibep would be the first targeted therapy for Sjögren's, offering an option beyond symptomatic dry-eye and dry-mouth management.

Medicine · Fierce Biotech · 22 Sept

Vertex’s midstage data amplify kidney disease market opportunity

Inaxaplin targets APOL1-mediated kidney disease, a genetic cause of rapid progression in patients of African ancestry; phase 2b signals efficacy beyond the pivotal trial population.

Urology · Fierce Biotech · 22 Sept

Parathyroid Storm Secondary to a Parathyroid Adenoma Presenting With Recurrent Generalised Tonic-Clonic Seizures and Refractory Hypercalcaemia: A Case Report

Refractory hypercalcaemia with seizures demands urgent parathyroidectomy, not just medical therapy; suspect parathyroid storm when calcium exceeds 4 mmol/L with neuropsychiatric decline.

Endocrinology · Cureus · 22 Sept

Efficacy of Magnesium Supplementation in Functional Constipation: A Systematic Review

4 of 7 studies showed significant between-group improvement in stool frequency; 4 of 6 reporting stool consistency showed significant between-group differences; both quality-of-life studies showed significant improvement.

Gastroenterology · Cureus · 22 Sept

Autoimmune Conversion of Hashimoto’s Thyroiditis to Graves’ Disease With Immune Pancytopenia in a Patient With Seropositive Rheumatoid Arthritis: A Diagnostic and Therapeutic Conundrum

In RA patients with cytopenias, check thyroid autoimmunity before starting antithyroid drugs, since conversion to Graves' can make ATD therapy hazardous.

Endocrinology · Cureus · 22 Sept