Archive

Faecal microbiota transplantation in irritable bowel syndrome (REFIT2): a randomised, double-blind, placebo-controlled, phase 3 trial.

Phase 3 data on FMT for IBS will tell you whether to offer it to refractory patients or keep managing them with diet, antispasmodics and neuromodulators.

Gastroenterology · Lancet · 24 Sept

Optimizing the delivery of radiotherapy with artificial intelligence.

AI already automates contouring, planning and QA in radiotherapy; knowing where it is validated tells you which tasks you can safely delegate.

Oncology · Nature reviews. Clinical oncology · 24 Sept

Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial.

Adds a CD47-blocker to standard second-line HER2 therapy in pretreated gastric cancer; check the response data before considering it for your patients.

Oncology · Nature Medicine · 24 Sept

Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement.

Microbiome composition tracked HF severity and clinical improvement, hinting at gut-derived targets or markers, but this is early mechanistic work with no therapy ready for patients.

Cardiology · Nature cardiovascular research · 24 Sept

Phase 1 Study of Anito-cel, a d-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma.

Of 38 treated, all 38 (100%) responded and 79% had complete response. At median follow-up 38.1 months, 24-month PFS was 57%, median PFS 30.2 months, 36-month OS 65%.

Oncology · NEJM · 24 Sept

Etuvetidigene Autotemcel for the Treatment of Wiskott-Aldrich Syndrome.

Severe infections fell from 2.00 to 0.15 per person-year (95% CI, 0.04 to 0.39); moderate or severe bleeding fell from 2.00 to 0.80 per person-year (95% CI, 0.49 to 1.22). Overall survival at 1 and 5 years was 96%.

Paediatrics · NEJM · 24 Sept

Clinical Uses of Common Genetic Variants Associated with Common Diseases.

Thousands of small-effect variants underpin polygenic risk; scores predict risk, yet have had little effect in the clinic. No effect sizes reported.

General Medicine · NEJM · 24 Sept

Pseudomonas aeruginosa induces the generation of pathogenic IFNγ(+)Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis.

Two pathogenic Th17 subsets, Th1/17+ and pTh17, were selectively enriched in CF lungs colonised by P. aeruginosa, derived from cTh17 precursors, and disrupted epithelial integrity.

General Medicine · Nature microbiology · 24 Sept

Transient Gestational Hypertension and Its Subsequent Maternal and Perinatal Outcomes

Women whose blood pressure normalises during admission may still carry raised risks, so prolonged surveillance rather than early discharge could change how you counsel and follow them.

Obstetrics & Gynaecology · Cureus · 24 Sept

Standardising Pleural Management in Suspected Malignant Pleural Effusion Using a Structured Pre-Test Probability and RED Score-Guided Proforma: A Single-Centre Before-and-After Quality Improvement Project

Unplanned admission or early review fell from 16/48 (33.3%) to 2/26 (7.7%); risk difference −25.6% (95% CI −42.5 to −8.8), P=0.021. Procedures beyond two: 33.3% to 22.7%, not significant.

General Medicine · Cureus · 24 Sept

Prevalence and Trends of Post–COVID-19 Sequelae Among U.S. Adults With Prior COVID-19 Infection, 2022–2024

PASC prevalence declined from 19.7% in 2022 to 15.1% in 2023 and 13.7% in 2024 (P<0.001 for 2022 vs subsequent years); 6,822 of 42,872 reported PASC. Higher in women and adults aged 35-64.

General Medicine · Cureus · 24 Sept

Oracle Health rolls out AI solutions for RCM, oncology as part of broader healthcare, life sciences strategy

If your hospital runs Oracle Cerner, expect AI-driven coding and oncology workflow tools to reach your EHR; ask how they handle clinical validation and billing accuracy.

Oncology · Fierce Healthcare · 24 Sept

Clinical Presentation of, Treatment Approaches for, and the Impact of Social Determinants of Health on Pediatric Catatonia: A Structured Qualitative Synthesis and Targeted Literature Review

Pediatric catatonia is underrecognised; this synthesis flags lorazepam/ECT response and how social factors delay diagnosis, so you consider it earlier in withdrawn or mute children.

Psychiatry · Cureus · 24 Sept

Update on the Management of Acute Sigmoid Volvulus: Endoscopic Decompression and Definitive Surgical Treatment

Endoscopic detorsion relieves the acute episode but recurrence is common, so plan elective sigmoidectomy in fit patients rather than repeated decompressions.

General Surgery · Cureus · 23 Sept

Clinical and Echocardiographic Characterization of Stage B Heart Failure in Asymptomatic Adults With Cardiovascular Risk Factors

Nearly all asymptomatic at-risk adults had echo abnormalities, so screening echocardiography in patients with hypertension or diabetes may catch pre-HF before symptoms.

Cardiology · Cureus · 23 Sept

Kyverna ‘resetting conversation’ with 1-year miv-cel data as autoimmune CAR-T peers hit safety snags

One-year miv-cel data show durable autoimmune disease control without the safety signals now troubling rival CAR-T programmes, informing referral discussions for refractory patients.

Medicine · Fierce Biotech · 23 Sept

August AI, operating global chatbot in stealth mode, rolls out U.S. telehealth services

A free AI chatbot used by millions now adds US telehealth, signalling where patients may increasingly take first-contact symptoms before reaching you.

General Medicine · Fierce Healthcare · 23 Sept

Weekly Rundown: Abridge poised for broader VA expansion; Hims & Hers builds out AI-native care

Ambient AI scribes are moving into national health systems, so expect similar documentation tools to reach your clinic within a few years.

General Medicine · Fierce Healthcare · 23 Sept

Hospitals' use of AI coding tools cost BCBSA plans $942M more for similar care: analysis

AI-assisted coding is inflating claims for similar care, so expect tighter audits and documentation scrutiny of your notes and diagnosis codes.

General Medicine · Fierce Healthcare · 23 Sept

Patient Comfort and Preference During Digital Versus Conventional Impressions for Fixed Prosthodontic Rehabilitation: A Comparative Study

Digital impressions were more comfortable and preferred by patients than conventional trays, so offering scanning where available may improve the chairside experience for fixed prosthodontic cases.

Medicine · Cureus · 23 Sept

Impact of the COVID-19 Pandemic on Chronic Liver Disease and Cirrhosis Mortality in the United States: A Divergent Trend Analysis by Underlying Etiology (2018-2024)

Alcohol-related cirrhosis deaths rose faster than other etiologies through the pandemic, so keep alcohol screening and hepatology follow-up high on your differential in at-risk patients.

Gastroenterology · Cureus · 23 Sept

Berry Street, Abbott partner to link Lingo CGM with nutrition coaching

Pairing an OTC CGM with dietitian coaching may improve glycaemic control in prediabetes and obesity, but outcome data are still lacking.

Endocrinology · Fierce Healthcare · 23 Sept

Clinical and Biochemical Responses to SGLT2 (Sodium-Glucose Cotransporter-2) Inhibitors in Patients With Rheumatic Heart Disease and Heart Failure

Adds Indian data on SGLT2 inhibitors in rheumatic heart disease heart failure, a group usually excluded from the landmark trials you rely on.

Cardiology · Cureus · 23 Sept

Effectiveness of Saline Nasal Irrigation in the Treatment of Rhinosinusitis and Allergic Rhinitis in Pediatric Patients: A Systematic Review

In acute sinusitis, irrigation improved nasal peak expiratory flow and quality of life (p < 0.05) but not radiographs. In allergic rhinitis, within-group gains only; between-group PC20 difference was not significant (p = 0.186).

Paediatrics · Cureus · 23 Sept

Recurrent Ischemic Stroke Despite Dabigatran Therapy: Unexpectedly Low Anti-IIa Activity Revealing Pharmacokinetic Treatment Failure

If a patient strokes on dabigatran, measure anti-IIa activity rather than assuming non-adherence — confirmed low levels may mean switching anticoagulant.

Neurology · Cureus · 23 Sept

Knowledge, Attitudes, Practices, and Perceptions of Occupational Health and Safety Among Healthcare Workers at a Tertiary Care Teaching Hospital in Jharkhand, India: A Cross-Sectional Study

Item-matched gaps between what staff know and what they do, plus incomplete hepatitis B vaccination, point to where your hospital's sharps and infection-control training is failing.

General Medicine · Cureus · 23 Sept

Epic shifts focus to cybersecurity while AI, interoperability agenda still on track, company says

If your hospital runs Epic, expect tighter security controls and continued AI and interoperability rollouts that will change how you document and share records.

General Medicine · Fierce Healthcare · 23 Sept

Immunovant ends cutaneous lupus program after phase 2 flop

Anti-FcRn therapy failed in cutaneous lupus, so don't expect this class as a steroid-sparing option for refractory skin disease; existing treatments remain the standard.

General Medicine · Fierce Biotech · 23 Sept

Periorbital Necrotizing Fasciitis Mimicking Allergic Oedema: A Diagnostic Pitfall

Periorbital swelling presumed allergic can be necrotizing fasciitis; failure to consider it delays debridement and antibiotics in a rapidly fatal infection.

Ophthalmology · Cureus · 23 Sept

STAT+: UnitedHealth, CVS push back on Medicare plan to curb remote patient monitoring

If CMS tightens remote monitoring billing, your RPM revenue and chronic-disease follow-up workflows could change; insurers are lobbying against the curbs.

General Medicine · STAT News — Health Tech · 23 Sept

Preconceptional Risk Factors Associated With Gestational Diabetes Mellitus and Pregnancy Outcomes: A Case-Control Study

Identifying preconceptional risk factors lets you flag and counsel women before conception, when lifestyle modification can still prevent gestational diabetes and its adverse birth outcomes.

Obstetrics & Gynaecology · Cureus · 23 Sept

Combined Pectoral Nerve Block and Intravenous Dexmedetomidine in Contemporary Multimodal Breast Cancer Analgesia: A Real-World Cohort Study

With baseline multimodal analgesia already yielding low pain scores, adding PECS block plus dexmedetomidine may offer little measurable opioid or pain benefit in your breast surgery patients.

Anaesthesiology · Cureus · 23 Sept

Barriers to Biomarker-Guided Advanced Breast Cancer Care in India: Diagnostic, Economic, and Implementation Challenges

Before prescribing HER2 or HR-directed therapy, check that your patient can actually access and afford the biomarker test — that gap, not drug choice, drives outcomes here.

Oncology · Cureus · 23 Sept

Characteristic MRI Features of Meckel’s Cave Venous Malformation: A Case Report

Recognising the characteristic MRI appearance of this rare Meckel's cave lesion can spare patients biopsy or surgery for what is a benign venous malformation.

Radiology · Cureus · 23 Sept

Longitudinal Anesthetic and Critical Care Management After Emergency Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury in an Adolescent: A Case Report

TEVAR with a 24 × 80-mm endograft achieved complete exclusion without endoleak. He was discharged home neurologically intact on day 50 with a patent, well-positioned endograft and no endoleak.

Anaesthesiology · Cureus · 23 Sept

Exclusive: Rio.ai raises Rs 43 Cr in pre-Series A led by Version One Ventures

Rs 43.08 crore raised via 7,130 CCPS at Rs 60,415 each; Version One led with Rs 21.30 crore; post-money valuation around Rs 170 crore

Medicine · Entrackr · 23 Sept

Roche’s phase 3 win tees up fight with Novartis for blockbuster kidney disease market

If approved, sefaxersen offers a new mechanism for IgA nephropathy, potentially delaying dialysis in patients you currently manage with renin-angiotensin blockade alone.

Urology · Fierce Biotech · 23 Sept

Musculoskeletal Adverse Event Signals Associated With Semaglutide, Liraglutide, and Tirzepatide in the US FDA Adverse Event Reporting System

GLP-1 users may report muscle and joint events; ask about myalgia and lean-mass loss at follow-up, especially in older patients on tirzepatide.

Endocrinology · Cureus · 23 Sept

Progressive Post-laminectomy Adult Spinal Deformity: A Case Study With a 24-Year Imaging Span

Long-term imaging shows deformity can progress for decades after lumbar decompression, so patients with prior laminectomy need periodic radiographic follow-up, not just symptom-based review.

Orthopaedics · Cureus · 23 Sept

Corneal Confocal Microscopy (CCM) in Patients With Central Neurodegenerative Disease

A quick, non-invasive eye scan may let you flag small-fibre nerve loss in Parkinson's or MS patients without biopsy or referral.

Ophthalmology · Cureus · 23 Sept