Archive

A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA

Markedly raised WT1 mRNA without blasts may flag occult myeloid malignancy in hypereosinophilia, so consider marrow WT1 testing before labelling it idiopathic.

General Medicine · Cureus · 25 Sept

Artificial Intelligence Versus Manual Measurement of Spinopelvic Sagittal Parameters Across Preoperative, Postoperative, and Instrumented Spines: A Systematic Review of Diagnostic Accuracy, Failure Rates, and Inferred Surgical Planning Implications

AI measures spinopelvic parameters accurately on preoperative films but fails more often on instrumented spines, so verify automated values before planning deformity correction.

Orthopaedics · Cureus · 25 Sept

Antimicrobial Resistance of Bacteria Isolated From Patients With Cancer

Enterobacteriaceae were 73.1% of isolates; ESBL prevalence 22.6%. E. coli MDR 51.0%, K. pneumoniae XDR 32.2%, Acinetobacter possible PDR 14.3%. E. coli resistance rose for ciprofloxacin and ceftriaxone in 2021.

Oncology · Cureus · 25 Sept

Psoriasis and Psoriatic Arthritis in Pregnancy: Current Evidence and Clinical Considerations

No primary data or effect sizes reported. Evidence suggests active or severe disease is linked to impaired fertility and worse pregnancy outcomes; flares are common postpartum despite pregnancy-related improvement in some women.

Obstetrics & Gynaecology · Cureus · 25 Sept

Left Inferior Pulmonary Vein Thrombosis and Secondary Lung Infarction Following Radiofrequency Catheter Ablation: A Diagnostic Challenge

Initial CT angiography read as isolated alveolar hemorrhage; repeat imaging at day 31 showed complete left inferior pulmonary vein thrombosis with secondary pulmonary infarction.

Cardiology · Cureus · 24 Sept

Lipedema-Related Outcomes During Gestrinone Treatment for Estrogen-Dependent Gynecological Disorders: A Real-World Retrospective Case Series

If gestrinone implants ease lipedema pain and limb volume alongside the gynaecological indication, it offers a dual-benefit option for women you already treat hormonally.

Obstetrics & Gynaecology · Cureus · 24 Sept

Bilateral Multifocal Serous Retinal Pigment Epithelial Detachments Coexisting With Generalized Rod-Cone Dysfunction Resembling Retinitis Pigmentosa

Multifocal serous PEDs with normal acuity can mask widespread rod-cone dysfunction, so consider ERG before attributing such detachments to central serous chorioretinopathy alone.

Ophthalmology · Cureus · 24 Sept

Cigna Group, OpenAI team up to support patients with complex conditions

Insurer-led AI navigation for cancer patients may change who coordinates your patients' care between visits, and what they bring to clinic.

Oncology · Fierce Healthcare · 24 Sept

Confirmed Myocarditis-Myositis Overlap Without Myasthenia Gravis: Evaluating for Triple M Syndrome Following Combined Enfortumab Vedotin and Pembrolizumab Therapy

Endomyocardial biopsy confirmed focal moderate lymphocytic myocarditis; troponin I, creatine phosphokinase, lactate dehydrogenase and transaminases were markedly elevated; acetylcholine receptor binding and muscle-specific kinase antibodies were negative.

Oncology · Cureus · 24 Sept

Inflammatory Eye Disease and Immunosuppressive Therapy: A Rheumatologist’s Perspective

Methotrexate and mycophenolate mofetil show comparable overall efficacy in randomised comparison; methotrexate favoured for posterior/panuveitis, mycophenolate for intermediate uveitis. Adalimumab has the strongest randomised evidence in noninfectious intermediate, posterior and panuveitis.

Ophthalmology · Cureus · 24 Sept

Cerebral/Cortical Visual Impairment in Primary Care: Extending the Evidence to Family Medicine

Family physicians rarely screen for CVI, a leading cause of childhood visual loss; asking about visual behaviour in children with developmental delay could catch it earlier.

Paediatrics · Cureus · 24 Sept

Overlapping Post-COVID Conditions: A Case of Myalgic Encephalomyelitis and Postural Orthostatic Tachycardia Syndrome Triggered by Sequential Epstein-Barr Virus (EBV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections

Diagnosed with ME/CFS in early 2023 and POTS later that year; low-dose naltrexone, duloxetine and PEA with pacing gave only partial, fluctuating response.

General Medicine · Cureus · 24 Sept

Campylobacter rectus Thoracic Empyema in a Severely Malnourished Host With Preserved Conventional Immune Markers: A Case Report and Literature Review

Consider oral periodontopathogens like C. rectus in empyema when routine cultures are sterile, even if standard immune markers look normal.

General Medicine · Cureus · 24 Sept

Giant Postpartum Ovarian Mixed Germ Cell Tumor Containing Mature Cystic Teratoma and Yolk Sac Tumor: A Case Report With Multimodality Imaging and Clinicopathological Correlation

Postpartum abdominal distension and amenorrhea can mask a germ cell tumour; consider imaging and AFP before assuming benign postpartum change.

Obstetrics & Gynaecology · Cureus · 24 Sept

Clot Out, Flow Back: Large-Bore Aspiration Thrombectomy for Symptomatic Early Transjugular Intrahepatic Portosystemic Shunt (TIPS) Occlusion

Transjugular recanalisation with large-bore aspiration thrombectomy and balloon angioplasty restored shunt flow with no residual stenosis; portosystemic gradient fell from 21 to 13 mmHg, with symptom improvement.

Gastroenterology · Cureus · 24 Sept

STAT+: The rise of the AI-native radiology practice

AI-native practices that own their own scanners can train and deploy imaging models in-house, which may change who reads your scans and how fast reports return.

Radiology · STAT News — Health Tech · 24 Sept

Comparative Effectiveness and Safety of Rebamipide Versus Diquafosol in the Treatment of Dry Eye Disease: A Systematic Review and Meta-Analysis

No significant difference between rebamipide and diquafosol: tear break-up time SMD -0.21 (95% CI -0.52 to 0.11), symptom scores SMD 0.11 (95% CI -0.16 to 0.38), corneal staining SMD -0.002

Ophthalmology · Cureus · 24 Sept

Sertoli-Leydig Cell Tumour With Heterologous Elements Presenting as Hyperandrogenaemia and Markedly Elevated Alpha-Fetoprotein: A Challenging Diagnosis

Young women with presumed PCOS and progressive virilisation need androgen and AFP testing, since a rare ovarian Sertoli-Leydig tumour can mimic PCOS for years.

Obstetrics & Gynaecology · Cureus · 24 Sept

Effectiveness of Antenatal Interventions in Preventing Pregnancy-Related Complications: A Systematic Review

Structured antenatal lifestyle and dietary interventions reduce gestational diabetes and preeclampsia risk, so prioritise them in routine ANC counselling rather than treating these outcomes as unavoidable.

Obstetrics & Gynaecology · Cureus · 24 Sept

Not All Brain Bleeds Are Equal: An Etiology-First Framework for Stroke Prevention After Intracerebral Hemorrhage

Before restarting a DOAC after ICH, weigh the bleed's cause: lobar amyloid bleeds recur more than deep hypertensive ones, so the anticoagulation decision should differ.

Neurology · Cureus · 24 Sept

Multi-method Machine-Learning Identification of IL11 as a Key Gene in Kidney Stone Disease: Mechanistic Clues and Diagnostic Potential

IL11 was significantly upregulated in Randall's plaque (Wilcoxon P=8.9×10⁻⁵). Single-gene diagnostic model: apparent AUC 0.782 (95% CI 0.663-0.901), out-of-bag AUC 0.756.

Urology · Cureus · 24 Sept

Clinical Performance and Safety of the Optima Non-compliant Percutaneous Transluminal Coronary Angioplasty Balloon in Contemporary Percutaneous Coronary Intervention: A Multicenter Real-World Study

Real-world multicentre data on a high-pressure NC balloon give you procedural success and short-term safety figures to weigh when choosing lesion preparation and stent optimisation devices.

Cardiology · Cureus · 24 Sept

Psychosocial Rehabilitation Interventions for Mental Health Disorders: A Systematic Review

Cognitive remediation, CBT-integrated programs, Housing First, peer-led rehabilitation and digital self-management showed potential benefits for negative symptoms, social functioning, housing stability, recovery and service utilization

Psychiatry · Cureus · 24 Sept

How to combat the insurer payment delays that are destabilizing independent medicine

Persistent No Surprises Act payment delays strain independent practice cash flow, so know the IDR timelines and documentation you can use to chase unpaid claims.

General Medicine · Fierce Healthcare · 24 Sept

Rifaximin Versus Placebo for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Global symptom relief improved with rifaximin (RR 1.54, 95% CI 1.13 to 2.11; p=0.014; NNTB 6), but heterogeneity was substantial (I2=59.5%) and the 95% prediction interval crossed no effect (0.89-2.67).

Gastroenterology · Cureus · 24 Sept

Acadia misses mark in Alzheimer’s but concludes phase 3 ‘absolutely worth’ pursuing

A negative phase 2 in Alzheimer's still advancing to phase 3 signals the endpoint may be wrong, not the drug — wait for phase 3 before discussing this with patients.

Neurology · Fierce Biotech · 24 Sept

Complete Response to First-Line Trastuzumab Deruxtecan in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Extra-axial Central Nervous System Metastases

Suggests T-DXd can be used first-line for HER2-positive extra-axial CNS metastases, where treatment options are limited and prognosis poor.

Oncology · Cureus · 24 Sept

Breaking the Storm: Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome as the First Manifestation of Systemic Lupus Erythematosus/Mixed Connective Tissue Disease in an Adolescent Successfully Treated With Anakinra

In a febrile adolescent not responding to antibiotics, consider MAS as the first sign of SLE; anakinra can achieve rapid remission.

Paediatrics · Cureus · 24 Sept

First Presentation With Impending Cardiac Tamponade Leading to a New Diagnosis of Mediastinal Lymphoma: A Shared Learning Case on the Atypical Presentation of Pericardial Effusion and Cardiac Tamponade

A young woman with dyspnoea and oedema but no full Beck's triad had tamponade from undiagnosed mediastinal lymphoma; keep effusion on the differential when the classic signs are absent.

Cardiology · Cureus · 24 Sept

STAT+: In radiology, AI is blurring the line between technology development and clinical practice

Practices building their own AI tools may soon compete for your imaging referrals, so know what 'AI-native' radiology claims actually deliver.

Radiology · STAT News — Health Tech · 24 Sept

Merck sees pivotal victory for $3B eye disease prospect

A trispecific intravitreal agent met its primary endpoint in DME, potentially adding a longer-acting option to anti-VEGF therapy if approved.

Ophthalmology · Fierce Biotech · 24 Sept

Multifocal Inflammatory Pseudotumor Involving the Orbit, Skull Base, and Cauda Equina Causing Progressive Visual Loss in a Patient With HIV Infection: A Case Report

In an HIV patient with progressive visual loss, consider inflammatory pseudotumor involving orbit and skull base, not just infection or lymphoma; biopsy guides steroid-sparing management.

Ophthalmology · Cureus · 24 Sept

Prospective Clinical Evidence on Artificial Intelligence-Enabled Augmented and Mixed Reality in Robot-Assisted Prostate and Kidney Cancer Surgery: A Systematic Review

Evidence for AI-guided augmented reality in robotic prostatectomy and partial nephrectomy is still sparse and heterogeneous, so treat these overlays as promising but unproven in your OR.

Urology · Cureus · 24 Sept

Aquatic Interventions for Children and Adolescents With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Motor, Sleep, Executive Function, and Adaptive Measures

Pooled estimates favored aquatic intervention for sleep (g = 1.76, 95% CI 1.16 to 2.37), motor and balance (g = 1.49, 95% CI 0.91 to 2.07), and executive function (g = 0.92, 95% CI 0.35 to 1.46); social and adaptive outcomes were not significant (g = 0.38, 95% CI −0.17 to 0.94).

Paediatrics · Cureus · 24 Sept

Short Implants Versus Sinus Floor Elevation With Standard Implants in the Atrophic Posterior Maxilla: A Systematic Review and Meta-Analysis

Short implants may avoid sinus lift surgery in atrophic posterior maxilla, sparing patients a second surgical site if survival and bone loss prove comparable.

Orthopaedics · Cureus · 24 Sept

Tuberculosis of the Sphenoid Sinus Causing Blindness in a Pediatric Patient: A Case Report

In a TB-endemic setting, consider sphenoid sinus TB in a child with vision loss and sinus opacities, since it mimics malignancy and delays cost vision.

Paediatrics · Cureus · 24 Sept

Cloud-Based AutoML Classification of Malignant and Non-malignant Colorectal Findings on Abdominal Computed Tomography: A Proof-of-Concept Study

At a 0.50 confidence threshold, average precision was 0.998, with precision and recall approximately 99%; 97% of malignant and 100% of non-malignant images were correctly classified.

Radiology · Cureus · 24 Sept

FSSAI proposes single-phase food warning labels, gives industry one-year transition time

Red hexagon labels on high sugar, fat and salt foods give you a concrete counselling tool for diet-related diabetes, obesity and hypertension in Indian patients.

General Medicine · ETHealthworld · 24 Sept

Grail survives adcomm vote as it awaits FDA decision for cancer blood test

A positive FDA panel vote moves Galleri closer to approval as a multi-cancer screening blood test, though its earlier trial miss means sensitivity limits still matter for how you counsel patients.

Oncology · Fierce Biotech · 24 Sept

Fumarate Hydratase-Deficient Renal Cell Carcinoma in a Solitary Kidney: Diagnostic Pitfalls and Onco-Nephrology Constraints in an Older Adult With Chronic Kidney Disease

FH-deficient RCC mimics papillary RCC; in a solitary kidney with CKD, misclassification can lead to nephrectomy when nephron-sparing options matter.

Urology · Cureus · 24 Sept