Archive

Central Auditory Processing Disorder in Children: A Multidisciplinary Approach

No quantitative results reported. The panel describes roles for each specialty: otolaryngology excludes peripheral causes, audiology tests central processing, psychology assesses cognitive and emotional factors.

Paediatrics · Cureus · 26 Sept

Mixed Autoimmune Hemolytic Anemia as the Initial Manifestation of Systemic Lupus Erythematosus: A Case Report

Hemoglobin 34 g/L, DAT positive for both IgG and IgM, ANA, anti-dsDNA and anti-Smith positive. Remission achieved with prednisolone, mycophenolate mofetil, belimumab and hydroxychloroquine.

General Medicine · Cureus · 26 Sept

Spatiotemporal Analysis of Dengue Incidence and Associated Factors: An Ecological Study Across Municipalities in Bahia, Brazil (2019-2024)

Incidence was lowest in 2021 (166.6 per 100,000) and highest in 2024 (1,558.7 per 100,000). Income was positively associated with incidence; sewerage coverage and Black/mixed-race proportion were negatively associated in 2024.

General Medicine · Cureus · 26 Sept

Glycemic Dynamics and Management Strategies in Individuals With Type 1 Diabetes During Ramadan: A Continuous Glucose Monitoring-Based Narrative Review

Glycaemic outcomes were heterogeneous, ranging from deterioration to temporary improvement or stability. Hypoglycaemia exposure did not appear to increase; postprandial hyperglycaemia clustered around the evening and pre-dawn meals was the predominant and most variable challenge.

Endocrinology · Cureus · 26 Sept

Relationship Between Gallbladder Wall Thickness and Perioperative Outcomes in Patients Undergoing Laparoscopic Cholecystectomy

Thickened gallbladder wall on preoperative imaging predicts harder dissection and worse perioperative outcomes, so plan ports, timing and conversion risk before elective laparoscopic cholecystectomy.

General Surgery · Cureus · 25 Sept

Access to Essential Medications for Burn Management Among Rural Communities in India: A Community-Based Cross-Sectional Study

Rural patients reaching you with burns may lack even basic topical and analgesic supplies at home, so plan discharge counselling and stock guidance accordingly.

General Surgery · Cureus · 25 Sept

Baseline Predictors of Crestal Bone Maintenance and Implant Stability Following Immediate Implant Placement With Platelet-Rich Fibrin: A Retrospective Observational Study

Baseline local and patient factors, not PRF alone, predicted crestal bone maintenance and stability after immediate implant placement, so case selection matters more than the adjunct.

Orthopaedics · Cureus · 25 Sept

Sequential Organ Failure Assessment Score as a Predictor of Intensive Care Unit Mortality in Patients With Maxillofacial Trauma: A Prospective Observational Study

25 of 130 died. Non-survivors had higher admission SOFA (11.0 ± 3.5 vs. 6.5 ± 3.0). A ΔSOFA above 1.5 gave 92.0% sensitivity and 81.0% specificity for mortality.

Anaesthesiology · Cureus · 25 Sept

Millions of Americans don't have a surgeon in their home county: study

Quantifies how far patients travel for surgical care, a workforce-access problem Indian districts also face when planning referral pathways.

General Surgery · Fierce Healthcare · 25 Sept

Comparison of Vocal Cord Function in Patients Undergoing Thyroid Surgery With and Without Microscopic Assistance

Microscopic assistance during thyroidectomy may reduce recurrent laryngeal nerve injury and preserve vocal cord function, so consider it for high-risk dissections.

General Surgery · Cureus · 25 Sept

Sorafenib-Induced Hand-Foot Skin Reaction in a Patient With Acute Myeloid Leukemia Following Haploidentical Stem Cell Transplantation: A Case Report

Painful symmetrical hyperkeratotic plantar plaques appeared approximately eight weeks after starting sorafenib, impairing daily activities; managed with topical keratolytic and corticosteroid therapy.

Oncology · Cureus · 25 Sept

Circadian-Based Optimization of Pharmacotherapy in Chronic Diseases: Integrating Pharmacokinetics, Pharmacodynamics, and Disease Rhythm

Timing some chronic-disease drugs to the body clock can change efficacy and toxicity, so review whether your patients' dosing schedules match their disease rhythm.

General Medicine · Cureus · 25 Sept

Sudden Onset Occipital Headache as a Presenting Feature of Ischaemic Stroke

MRI showed a 3.5 cm acute right occipital infarct; CT was normal. Formal perimetry revealed a left superior homonymous quadrantanopia missed on bedside confrontation.

Neurology · Cureus · 25 Sept

Stroke Mimics in a Tertiary Comprehensive Stroke Center: Implications for Healthcare Provider Education

True strokes were 35.1% (221/630); mimics 64.9% (409/630). Leading mimics: sepsis 5.7%, migraine 4.6%, seizure 3.3%, subdural hematoma 3.3%, hypertensive emergency 3.3%.

Neurology · Cureus · 25 Sept

Persistent Type B Hyperlactataemia as a Diagnostic Clue to Occult Diffuse Large B-cell Lymphoma-Associated Haemophagocytic Lymphohistiocytosis

Lactate stayed elevated despite fluids and no acidosis; HScore 186 with hypertriglyceridaemia and raised LDH. Bone marrow biopsy confirmed DLBCL. R-mini-CHOP normalised lactate, counts and liver function, with complete metabolic response on PET-CT after two cycles.

General Medicine · Cureus · 25 Sept

Long-Term Cardiovascular, Thromboembolic, and Malignancy Safety of Janus Kinase (JAK) Inhibitors in Dermatologic and Rheumatologic Populations: A Narrative Comparative Review

Before starting long-term JAK inhibitors for psoriasis or rheumatoid arthritis, weigh the persistent cardiovascular, thromboembolic and malignancy signals against the patient's baseline risk.

Medicine · Cureus · 25 Sept

Management, Practice, and Outcomes of Fragility Fractures and Osteoporosis Care at a Tertiary Hospital in Riyadh, Saudi Arabia

Reinforces that post-fragility-fracture osteoporosis treatment is routinely missed, so build secondary-prevention pathways rather than relying on age to flag risk.

Orthopaedics · Cureus · 25 Sept

Ticagrelor-Induced Bradyarrhythmias in Acute Coronary Syndrome: A Case Series of Three Patients

All three developed high-grade AV block, asystole or cardiac arrest after ticagrelor; two recovered after switching to prasugrel, one needed a permanent pacemaker. Naranjo rated the association possible in each.

Cardiology · Cureus · 25 Sept

Why Seizures Break Through: Distinguishing Background Susceptibility From Proximal Precipitants in Patients With Epilepsy

Distinguishing a patient's baseline seizure susceptibility from an immediate trigger like missed doses or sleep loss changes whether you reassure, adjust ASM, or investigate.

Neurology · Cureus · 25 Sept

Perioperative Safety Considerations and Surgical Outcomes Associated With GLP-1-Based Therapies: A Systematic Review

Observational studies showed increased residual gastric contents or delayed gastric emptying with GLP-1 RAs, especially semaglutide, despite standard fasting; clinically apparent aspiration or regurgitation was uncommon and mainly in case reports.

Anaesthesiology · Cureus · 25 Sept

Medical devices PLI scheme drives local output of MRI, CT scanners, heart valves: Centre

Domestically made MRI, CT and heart valves should mean cheaper, faster procurement and servicing for your hospital, though clinical equivalence data is not yet presented.

Medicine · ETHealthworld · 25 Sept

Robotic vs. Laparoscopic Stapling in Robotic Total Mesorectal Excision: A Prospective Cohort Study

Robotic stapling may cut the number of firings needed in rectal transection, potentially lowering anastomotic leak rates after TME.

General Surgery · Cureus · 25 Sept

Staged Reduction and Combined Anterior and Posterior Minimally Invasive Fixation for a Highly Unstable Open-Book Pelvic Ring Fracture: A Case Report

Computed tomography confirmed pubic symphysis reduction after external fixation, but posterior sacral fracture widening became apparent. Staged reduction and combined anterior and posterior minimally invasive fixation achieved satisfactory reduction and favorable functional recovery maintained at three years.

Orthopaedics · Cureus · 25 Sept

Postnatal Hypertension Management and Discharge Documentation: A Retrospective Clinical Audit at a UK University Hospital

Valid discharge BP recorded in 146/148 (98.6%), 118/146 (80.8%) below 140/90 mmHg. BP parameter plans documented in 27/148 (18.2%), two-week GP review in 34/147 (23.1%), clear discharge communication in 16/148 (10.8%).

Obstetrics & Gynaecology · Cureus · 25 Sept

Accuracy, Relevance, and Redundancy of ChatGPT-5.3 References in Open Fracture Management: A Methodological Analysis

11 of 45 references (24.4%) were fully accurate; 19 (42.2%) had bibliographic errors; 15 (33.3%) were unverifiable. Content relevance was 30 (66.7%).

Orthopaedics · Cureus · 25 Sept

High-Dose Tigecycline for Multidrug-Resistant Serratia Infections in Critically Ill Adults: A Systematic Review of Direct and Indirect Clinical Evidence

Evidence for high-dose tigecycline in resistant Serratia is indirect, so treat it as a last-line option and weigh the mortality signal before escalating the dose.

General Medicine · Cureus · 25 Sept

Anticoagulation Dilemma in a Patient With Pulmonary Embolism and Massive Haemoptysis

Haemoptysis worsened after starting apixaban and persisted despite dose adjustments; she was stabilised and discharged on warfarin. No laboratory or outcome figures reported.

General Medicine · Cureus · 25 Sept

Unmasking a Rare Triad of Iron Deficiency Anemia, Esophageal Web, and Dysphagia in Plummer-Vinson Syndrome: A Case Report and Review of the Literature

Severe microcytic hypochromic anemia with low serum ferritin and an esophageal stricture on barium swallow confirmed Plummer-Vinson syndrome; no outcome data reported.

Gastroenterology · Cureus · 25 Sept

Validation of the Nassar Preoperative Risk Scale to Predict Intraoperative Difficulty in Patients Undergoing Laparoscopic Cholecystectomy

Difficult LC occurred in 12.76%. Scale showed AUC 0.884, sensitivity 76.7%, specificity 87.8%, accuracy 86.4%, PPV 47.86%, NPV 96.26%.

General Surgery · Cureus · 25 Sept

IcoSema in Weight Management and Glycaemic Control: A Systematic Review and Meta-Analysis

A weekly insulin-semaglutide combo may cut injections while limiting insulin-related weight gain and hypoglycaemia, but heterogeneous comparators mean efficacy estimates remain uncertain.

Endocrinology · Cureus · 25 Sept

An Unsuspected Adult Intestinal Malrotation Presenting With Left-Sided Appendicitis, With the Diagnosis First Suggested by Purulent Drainage From the Appendiceal Orifice During an Elective Colonoscopy

Purulent drainage from the appendiceal orifice at colonoscopy; isolated left iliac fossa tenderness, no leukocytosis, 76% neutrophils, CRP 6.7 mg/dL; CT showed malrotation with inflamed appendix left of midline.

General Surgery · Cureus · 25 Sept

Radiotherapy versus observation following surgical resection of WHO grade 2 atypical meningioma (ROAM/EORTC-1308): an international, multicentre, open-label, phase 3, randomised controlled trial.

After complete resection of grade 2 meningioma, adjuvant radiotherapy delays recurrence but does not improve overall survival, so timing and patient selection matter more than routine referral.

Neurology · Lancet · 25 Sept

Redesigning cardiovascular medicine around sex differences.

Women's cardiovascular risk and presentation differ from men's; the evidence base you rely on was built mostly in men, so diagnostic thresholds and treatments may not fit your female patients.

Cardiology · Nature Medicine · 25 Sept

Unraveling the lexicon of complex mutational phenomena in human cancers.

No new data; the review clarifies ambiguous definitions and proposed origins of these eight phenomena and notes their reported associations with mutational processes, drug resistance and clinical outcomes

Oncology · Nature cancer · 25 Sept

Cardiac proteomic and phosphoproteomic profiling defines clinically relevant molecular subgroups in human heart failure.

Etiology-stratified analyses showed convergence to a shared end-stage proteomic landscape, but unbiased proteome-based clustering identified two molecular subgroups with divergent fibrosis and immune infiltration; subgrouping proteins also predicted survival in an independent plasma cohort.

Cardiology · Nature cardiovascular research · 25 Sept

Immunogenicity and safety of high-dose versus double-dose quadrivalent inactivated influenza vaccine in adult kidney transplant recipients: a randomized controlled trial (2023).

Seroconversion to at least one strain was 95.2% with high-dose versus 69% with double-dose (P = 0.002); absolute difference 0.26 (95% CI, 0.12-0.40). Injection site pain and myalgia were less common with high-dose.

General Medicine · Lancet regional health. Southeast Asia · 25 Sept

Diverse Clinical Spectrum of TTN-Truncation Variant Cardiomyopathy: A Case Series Illustrating Asymptomatic, Arrhythmic, Recurrent Takotsubo, and Inflammatory Phenotypes

Four cases: asymptomatic moderate LV systolic dysfunction found on screening; ventricular tachycardia storm needing multiple ablations and ICD shocks; two discrete takotsubo episodes; FDG-PET myocardial inflammation responding to corticosteroids

Cardiology · Cureus · 25 Sept

Perioperative Spinal Cord Stimulation Combined With Targeted Muscle Reinnervation for Chronic Neuropathic Pain: A Case Report

In amputees with refractory phantom limb pain, combining spinal cord stimulation with targeted muscle reinnervation may control pain when drugs alone fail, though this is a single case.

Anaesthesiology · Cureus · 25 Sept

Automated Tractography of Corticospinal and Corticoreticular Projections Originating From Brodmann Area 44 in Patients With Mild Stroke

FA was lower in the lesioned hemisphere for both BA44-origin corticospinal projections (0.484 vs 0.508, P = 0.011) and corticoreticular projections (0.442 vs 0.463, P = 0.049).

Neurology · Cureus · 25 Sept

Local Anesthetic Systemic Toxicity Following High-Volume Ropivacaine, Epinephrine, Clonidine, and Ketorolac (RECK) Infiltration During Total Knee Arthroplasty: A Case Report

Cumulative ropivacaine dose was 286 mg (3.9 mg/kg). Acute confusion and focal right arm myoclonic activity developed in the post-anesthesia care unit without cardiovascular instability; lipid emulsion produced rapid complete neurological recovery.

Anaesthesiology · Cureus · 25 Sept