Archive

Phylogeny-agnostic strain-level prediction of phage-host interactions from genomes using machine learning.

Could speed matching of phages to a patient's resistant strain, making phage therapy practical where antibiotic options are exhausted.

General Medicine · Nature microbiology · 29 Sept

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial.

An oral GLP-1 agonist taken without fasting or diet rules could offer injection-free glycaemic control for early type 2 diabetes, pending full efficacy and safety data.

Endocrinology · Nature Medicine · 29 Sept

Exercise Therapy and Education for Young Adults With Persistent Knee Problems After Anterior Cruciate Ligament Reconstruction : A Randomized Clinical Trial.

At 4 months KOOS4 improved 14.1 with SUPER versus 9.4 control (adjusted mean difference 4.8, 95% CI 1.4 to 8.2). Global rating of change for pain 73% versus 40%. No cartilage differences.

Orthopaedics · Annals · 29 Sept

FDA Approves First Treatment for MCT8 Deficiency

First approved therapy for this rare X-linked thyroid hormone transport defect; tiratricol lowers peripheral thyrotoxicosis, so paediatricians and endocrinologists can now offer disease-directed treatment rather than supportive care.

Endocrinology · FDA — Press Announcements · 29 Sept

When Morphology Falls Short: ATP1B1::PRKACB Fusion in a Morphologically Atypical Pancreatic Intraductal Oncocytic Neoplasm

Atypical pancreatic intraductal lesions lacking classic oncocytic features can still harbour PRKACB fusions, so molecular testing may be needed when morphology alone is ambiguous.

Gastroenterology · Cureus · 29 Sept

Psoriatic Arthritis Without Cutaneous Manifestations: A Case of Diagnostic Delay, Pathologic Progression, and Psychological Burden

No skin lesions; family history of psoriasis in daughter and grandson prompted PsA diagnosis. DMARD plus escitalopram gave significant pain and mood improvement within one month.

General Medicine · Cureus · 29 Sept

Diagnostic Challenges and Uterus-Conserving Surgical Management Following Systemic Multi-dose Methotrexate for a Left Interstitial Pregnancy

Interstitial ectopic can mimic early intrauterine pregnancy on TVUS; multi-dose methotrexate may fail, so keep laparotomy and cornual resection ready to preserve the uterus.

Obstetrics & Gynaecology · Cureus · 29 Sept

Immunomodulatory Properties of Mesenchymal Stem Cells and Their Extracellular Vesicles: Potential Clinical Applications in Autoimmune Diseases

MSC-derived exosomes may offer cell-free immunomodulation for autoimmune disease, but this is a narrative review — no trial data yet to change your practice.

General Medicine · Cureus · 29 Sept

Multiple Myeloma Presenting as a Pancoast-Like Tumor: A Diagnostic Challenge

An apical lung mass in a smoker is not always Pancoast carcinoma; myeloma can mimic it, so biopsy before committing to lung-cancer treatment.

Oncology · Cureus · 28 Sept

Complete Heart Block in Young Patient With Systemic Lupus Erythematosus: A Case Report

In young SLE patients, screen for conduction disease with baseline ECG even without syncope, since complete heart block can be asymptomatic and need pacing.

Cardiology · Cureus · 28 Sept

Legal Frameworks for Governing Generalist and Agentic Artificial Intelligence in Medical Imaging

Regulators approve fixed single-task imaging AI, but agentic systems that chain models and act on findings fall outside that framework, so accountability for their output is currently unclear.

Radiology · Cureus · 28 Sept

Comparing General Anaesthesia With Spinal Anaesthesia for Holmium Laser Enucleation of Prostate: A Systematic Review and Meta-Analysis

Spinal anaesthesia for HoLEP appears comparable to general anaesthesia, so comorbid BPH patients may avoid airway and systemic risks of GA.

Urology · Cureus · 28 Sept

Beyond Hematuria: An Unexpected Diagnosis of Autosomal Dominant Polycystic Kidney Disease in a Young Adult Without a Family History

In a young adult with hematuria, don't stop at UTI or stones—absence of family history does not exclude ADPKD, and imaging plus renal function changes management.

General Medicine · Cureus · 28 Sept

Non-Hormonal Treatments for Vasomotor Symptoms of Menopause: An Up-to-Date Review

No trial data or effect sizes reported; non-hormonal options show variable effects and potency, with fewer side effects and contraindications than hormonal therapy

Obstetrics & Gynaecology · Cureus · 28 Sept

Fat Emboli Entrapped in the Tricuspid Valve Chordae Following Autologous Fat Grafting: An Echocardiographic-Pathological Correlation

Fat embolism after lipofilling can cause cardiac arrest in healthy young patients; echocardiography showing tricuspid chordae entrapment may aid post-mortem and antemortem diagnosis.

Cardiology · Cureus · 28 Sept

Serum Vascular Endothelial Growth Factor and C-reactive Protein Serve As Biomarkers of Joint Health in Severe Haemophilia A: A Cross-Sectional Study From India

VEGF and CRP may flag haemophilic joint damage in Indian patients on on-demand factor, where imaging and prophylaxis access are limited.

General Medicine · Cureus · 28 Sept

OpenEvidence partners with Anthropic, Penn Medicine to expand physician access to AI across Africa and Asia

If you practise where specialist advice is scarce, this puts an AI second opinion on drug and diagnostic decisions at the point of care.

General Medicine · Fierce Healthcare · 28 Sept

Microwave Ablation Versus Radiofrequency Ablation for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Initial complete ablation was similar (28 studies, 6,036 participants; RR 1.01, 95% CI 1.00-1.02). MWA reduced local tumour progression (27 studies, 5,166 participants; RR 0.67, 95% CI 0.54-0.83), consistent in randomised trials (RR 0.55, 95% CI 0.40-0.76).

Oncology · Cureus · 28 Sept

Carbohydrate Quality Versus Quantity in Gestational Diabetes Mellitus While Considering Randomized Dietary Interventions: A Systematic Review

When counselling GDM patients on diet, prioritising low-glycaemic-index carbohydrates over strict carb counting may be the more defensible first-line advice.

Obstetrics & Gynaecology · Cureus · 28 Sept

Atypical Presentation of a Meningioma Masquerading as Trigeminal Neuralgia: A Diagnostic Challenge in the Emergency Department

Atypical features (prolonged sensory loss, proptosis, diplopia) prompted imaging; CT showed a sclerotic sphenoid lesion, MRI revealed a large en plaque meningioma with orbital extension and optic nerve compression, plus a separate right cerebellopontine angle meningioma.

Neurology · Cureus · 28 Sept

Complement Factor H Mutation-Associated Atypical Haemolytic Uraemic Syndrome Presenting With Dialysis-Dependent Renal Failure: A Case Report

Renal biopsy showed thrombotic microangiopathy; genetic testing found a pathogenic complement factor H splice site mutation. He required urgent dialysis and remains dialysis dependent after declining eculizumab

Urology · Cureus · 28 Sept

Reproductive and Gynecologic Effects of Glucagon-Like Peptide-1 Receptor Agonists in Women With Polycystic Ovary Syndrome: A Scoping Review

Before prescribing GLP-1 agonists to PCOS patients for weight loss, know the evidence on menstrual regularity, ovulation and fertility is still only scoping-level.

Obstetrics & Gynaecology · Cureus · 28 Sept

Laparoscopic and Robot-Assisted Surgery for Gestational Trophoblastic Disease: A Scoping Review of Patient Selection and Intraoperative Precautions

Guidelines cover when to operate for GTD but not the route; this maps selection criteria and intraoperative precautions for laparoscopic or robotic hysterectomy.

Obstetrics & Gynaecology · Cureus · 28 Sept

Association of Serum Magnesium Concentration With Microvascular Complications Among Patients Diagnosed With Type 2 Diabetes Mellitus: An Observational Cross-Sectional Analysis

Low serum magnesium tracked with retinopathy, nephropathy and neuropathy in T2DM patients; consider checking magnesium in poorly controlled diabetes rather than ignoring it.

Endocrinology · Cureus · 28 Sept

Reverse Takotsubo Cardiomyopathy Complicated by Neurogenic Pulmonary Edema in Aneurysmal Subarachnoid Hemorrhage: A Case Report

In aSAH, basal hypokinesis with apical sparing plus neurogenic pulmonary edema can mimic acute MI; recognise it to avoid inappropriate thrombolysis or angiography.

Cardiology · Cureus · 28 Sept

Benefit and Harm in the Early Management of Suspected Cervical Spine Injury: A Narrative Review

Rigid collars, sequential imaging and steroids in suspected cervical injury are largely reflexive; this review weighs the evidence for each, so you can drop what harms.

Orthopaedics · Cureus · 28 Sept

Diagnostic Challenges of Regional Cardiac Tamponade in a Severely Volume-Overloaded Dialysis Patient: The Role of Multimodality Imaging

In dialysis patients with unexplained tachycardia, regional tamponade can hide without classic echo signs; multimodality imaging is needed before attributing it to volume overload.

Cardiology · Cureus · 28 Sept

Multidisciplinary Antimicrobial Stewardship Program in an Indian ICU: A Time-Series Analysis of Diagnostic Practices and Antibiotic Use

A multidisciplinary AMSP in an Indian ICU changed diagnostic and prescribing practice, giving you a locally tested model to cut unnecessary antibiotic use in your own unit.

General Medicine · Cureus · 28 Sept

Govt, private hospitals likely to be graded on quality & safety

Publicly benchmarked hospital grades would let you and your patients compare safety and outcomes across government and private facilities before referral.

Medicine · ETHealthworld · 28 Sept

Bone Marrow Aplasia Under Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: A Rare and Unpredictable Complication

Rare but severe cytopenias can appear months into imatinib or nilotinib, so check marrow, not just counts, when a stable CML patient drops.

Oncology · Cureus · 28 Sept

Temporal Trends and Demographic Contributions to Stroke Burden in India, 1990–2023: An Analysis of Global Burden of Disease 2023 Estimates Using Shapley Decomposition and Joinpoint Regression

Incident cases rose from 0.73 million to 1.87 million (155.1%), deaths from 0.42 million to 1.03 million (148.2%), DALYs from 12.41 million to 25.99 million (109.4%). Age-standardised incidence stable; mortality and DALY rates declined.

Neurology · Cureus · 28 Sept

Prevalence and Clinical Characteristics of Myocardial Infarction With Non-obstructive Coronary Arteries Compared With Obstructive Myocardial Infarction: A Retrospective Tertiary-Centre Study

MINOCA was 2.9% of MIs. MINOCA patients were younger (52.1 vs 59.8 years; p=0.005) and more often presented as NSTEMI (51.4% vs 13.9%; p<0.001).

Cardiology · Cureus · 28 Sept

A Prospective Comparative Study of Opioid-Free Anesthesia and Opioid-Based Anesthesia for Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgeries: A Double-Blinded Randomized Controlled Trial

Opioid-free anesthesia in laparoscopic surgery may cut PONV and respiratory depression while matching postoperative analgesia, so consider it for patients at risk of opioid side effects.

Anaesthesiology · Cureus · 28 Sept

Association Between Time-Weighted Haemoglobin A1c and Longitudinal Changes in Growth Parameters Among Children With Type 1 Diabetes: A Retrospective Cohort Study

Each unit rise in time-weighted HbA1c was associated with a fall in height-for-age z-score (beta -0.15, 95% CI -0.26 to -0.04). Effect was larger with diabetes duration over 5 years (beta -0.22) and baseline HbA1c over 9% (beta -0.28).

Paediatrics · Cureus · 28 Sept

Comparative Analysis of Vonoprazan- and Dexlansoprazole-Based Therapies for Helicobacter pylori Eradication: A Single-Center Retrospective Observational Study

Eradication was 93.15% (95% CI 84.95-97.04) with vonoprazan versus 83.56% (95% CI 73.43-90.34) with dexlansoprazole; the difference did not reach significance (p = 0.07).

Gastroenterology · Cureus · 28 Sept

Study of Ocular Fundus Changes in Pregnancy-Induced Hypertension and Visual Outcomes After Delivery

Fundus changes in PIH often regress after delivery, so retinal assessment can guide counselling and identify the few women needing postpartum ophthalmology follow-up.

Obstetrics & Gynaecology · Cureus · 28 Sept

Factors Associated With Recurrence in Patients With Benign Paroxysmal Positional Vertigo Following Canal Repositioning Therapy

Recurrence after repositioning is common, so identifying which BPPV patients need closer follow-up and explicit counselling about relapse risk can reduce repeat ED visits.

Neurology · Cureus · 28 Sept

Trajectories of Glycemia Following Acute Pancreatitis: A Prospective Longitudinal Study

After acute pancreatitis, monitor glucose beyond discharge — a substantial share develop persistent dysglycemia, so early HbA1c and fasting glucose testing can catch new diabetes.

Gastroenterology · Cureus · 28 Sept

Emerging Biomarkers in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Current Evidence, Clinical Utility, and Future Perspectives

Cytokeratin-18 fragments, FGF-21, adipokines, inflammatory cytokines, extracellular vesicles, microRNAs, metabolomic signatures and gut microbiota metabolites all show potential, but none meets all criteria to universally replace biopsy.

Gastroenterology · Cureus · 28 Sept

Brexpiprazole in India and the United States: A Comparative Review of Regulatory Status, Clinical Evidence, Market Access, and Evidence Gaps

Brexpiprazole is FDA-approved for schizophrenia, MDD augmentation and Alzheimer's agitation, but India-specific efficacy and access data remain sparse, so prescribing here rests on extrapolated evidence.

Psychiatry · Cureus · 28 Sept