Archive

Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.

Card-verified MCV1 uptake was higher with NutriVax (odds ratio 2.08, 95% CI 1.30-3.35, P = 0.004); difference-in-differences showed a 20.1 percentage-point increase from baseline (95% CI 13.7-26.5 pp, P < 0.0001).

Paediatrics · Nature Medicine · 2 Oct

FDA Approves First Heart Valve Designed to Grow with Children

A pulmonary valve that can be expanded in clinic may spare children with congenital pulmonary valve disease repeated open-heart replacements as they grow.

Paediatrics · FDA — Press Announcements · 2 Oct

Microbiome testing company Tiny Health clinches $33M to scale research, enterprise partnerships

Gut microbiome testing is not yet standard in Indian practice; this funding may expand validated assays and trial data you could eventually order for GI and allergy patients.

Gastroenterology · Fierce Healthcare · 1 Oct

Payerset launches AI-powered research assistant to help health systems benchmark payer rates

If your hospital uses it, contract negotiations could rest on faster, more complete payer rate comparisons rather than manual benchmarking.

Medicine · Fierce Healthcare · 1 Oct

Hospitals' body calls for balanced pricing of drugs, consumables; opposes uniform 16% margin

A flat 16% margin on drugs and consumables could change what your hospital stocks and bills, so watch how this pricing policy lands.

General Medicine · ETHealthworld · 1 Oct

Opinion: Claude analyzed my genome in 30 minutes. Now we need standards for the results

AI can now interpret a whole genome in minutes, so you will soon face patient-carried genomic reports with no validated standard behind them.

General Medicine · STAT News — Health Tech · 1 Oct

Antler, Nikhil Kamath back healthtech startup Aignosis with Rs 4 Cr seed round

Company claims more than 8,000 screenings completed; deployed in over 20 government Primary Health Centres in Rajasthan; plans at least 1 lakh screenings by end of FY27.

Paediatrics · Entrackr · 1 Oct

420 million screened for hypertension, diabetes under central scheme: Nadda

Population-level NCD screening at this scale means more newly diagnosed hypertension and diabetes patients will present to you for confirmation and treatment.

General Medicine · ETHealthworld · 1 Oct

Longitudinal Mood Monitoring and Classification of Self-Reported Mental Health Status Using Feels.ai: Feasibility Study

App-collected mood and behavioural data distinguished users reporting a mental health condition from those without, hinting at passive screening tools, though this feasibility study cannot yet support clinical use.

Psychiatry · Cureus · 1 Oct

Ultrasound-Guided Distal Thoracolumbar Fascia Hydrodissection at the Gluteal Junction: A Technical Report With Cadaveric Assessment of Compartmental Spread and Gross Neural Sparing

Cephalad spread to approximately L3 in 6/6 sides (100%); multifidus and longissimus thoracis staining 6/6 (100%); iliocostalis lumborum 0/6 (0%); no dye in sciatic nerve, sacral plexus, neural foramina, or epidural space (0/6).

Anaesthesiology · Cureus · 1 Oct

Comparison of Early Intrapleural Fibrinolytic Therapy, Versus Administration After Failure of Intercostal Drainage in Children with Empyema Thoracis: A Systematic Review.

Timing of intrapleural fibrinolytics in childhood empyema remains unresolved; this review weighs whether early instillation shortens drainage and hospital stay versus waiting for ICD failure.

Paediatrics · Indian pediatrics · 1 Oct

Microbial Etiology of Empyema Thoracis in Children: A Systematic Review and Meta-Analysis.

Knowing which organisms dominate childhood empyema guides empiric antibiotic choice before culture results return, especially where pneumococcal vaccination coverage is incomplete.

Paediatrics · Indian pediatrics · 1 Oct

Clinical Practices for Management of Empyema Thoracis in Children: A Survey of Pediatricians in India.

Survey reveals wide variation in how Indian paediatricians diagnose and treat childhood empyema, flagging areas where practice diverges from evidence ahead of national guidelines.

Paediatrics · Indian pediatrics · 1 Oct

Five-year survival with neoadjuvant therapy in melanoma: updated pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).

Confirms 5-year survival gains with neoadjuvant ICIs in resectable stage IIIB-D melanoma, supporting this as standard practice over upfront surgery.

Oncology · Nature Medicine · 1 Oct

Effects of semaglutide on kidney disease in type 2 diabetes: a randomized placebo-controlled trial.

Semaglutide 1 mg weekly preserved kidney function over 52 weeks in T2D with CKD, supporting a GLP-1 option alongside SGLT2 inhibitors for renal protection.

Endocrinology · Nature Medicine · 1 Oct

Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes.

A dual GLP-1/glucagon agonist may offer added weight and glycaemic benefit over current GLP-1 agonists in patients with obesity and type 2 diabetes.

Endocrinology · NEJM · 1 Oct

Comparative Efficacy, Safety, and Cost of Different Intrapleural Fibrinolytic Agents for the Management of Empyema Thoracis in Children: A Systematic Review.

Urokinase and alteplase appear comparable for draining pediatric empyema, but cost differences may decide which agent your hospital stocks.

Paediatrics · Indian pediatrics · 1 Oct

Intrapleural Fibrinolytic Therapy Versus Video-Assisted Thoracoscopic Surgery, as the Initial Treatment Modality, in Children with Empyema Thoracis: A Systematic Review and Meta-Analysis.

Supports starting intrapleural fibrinolytics before VATS in paediatric empyema, sparing children surgery if outcomes are comparable.

Paediatrics · Indian pediatrics · 1 Oct

Efficacy, Safety, and Long-Term Outcomes of Shorter (≤ 4 Weeks) Versus Longer (> 4 Weeks) Antibiotic Therapy in Pediatric Empyema Thoracis: A Systematic Review.

Shorter courses may control pediatric empyema as well as prolonged ones, sparing children weeks of antibiotics and limiting resistance without worsening outcomes.

Paediatrics · Indian pediatrics · 1 Oct

Predictors of Failure of Medical Management in Children with Empyema Thoracis: A Systematic Review.

Knowing which clinical and radiological features predict failed medical management in paediatric empyema helps you decide early when to call the surgeon.

Paediatrics · Indian pediatrics · 1 Oct

All-fiber wireless auscultation garment for cardiopulmonary diagnostics.

The garment captured cardiopulmonary sounds and qualitative pathological features such as cardiac murmurs, S3 gallops and crackles, and suppressed environmental noise compared with a digital stethoscope.

Cardiology · Nature cardiovascular research · 1 Oct

Intrapleural Fibrinolytic Therapy as the Initial Modality, Compared to no Intrapleural Fibrinolytic Therapy, in Children With Empyema: A Systematic Review and Meta-analysis.

Pooled odds ratio for failure of therapy was 0.15 (95% CI 0.04-0.50) with fixed-effect model, but 0.14 (95% CI 0.02-1.12) with random-effects model. Serious adverse events were rare and comparable.

Paediatrics · Indian pediatrics · 1 Oct

Thoracic Computed Tomography Scan Versus Thoracic Ultrasonography for Management Decisions in Empyema Thoracis: A Systematic Review.

CT found one additional loculated case and one unconfirmed lung abscess; USG showed fibrin strands in all 13 that CT missed; both detected consolidation in 11; no cost or adverse event data

Paediatrics · Indian pediatrics · 1 Oct

Giredestrant plus Everolimus in Advanced Breast Cancer.

In 207 ESR1-mutated patients, median PFS was 10.0 months with giredestrant-everolimus versus 5.5 months with standard therapy-everolimus (HR 0.38; 95% CI 0.27 to 0.54; P<0.001). Overall population: 8.8 versus 5.5 months (HR 0.56; 95% CI 0.44 to 0.71).

Oncology · NEJM · 1 Oct

Early Versus Late(r) Administration of Intrapleural Fibrinolytic Therapy in Children with Empyema: A Systematic Review and Meta-Analysis.

No RCT addressed the review question. Of 3,110 citations identified, none compared early IPFT (within 24 h of empyema confirmation) with later instillation, so no pooled odds ratios or mean differences could be calculated.

Paediatrics · Indian pediatrics · 1 Oct

Double Jeopardy: Spontaneous Coronary Artery Dissection and Stress-Induced Cardiomyopathy

In women with acute coronary syndrome and no atherosclerotic culprit, consider SCAD and Takotsubo together; both are triggered by stress and management diverges.

Cardiology · Cureus · 1 Oct

Association Between Consulting Multiple Healthcare Facilities and Medication Burden Among Older Outpatients

Positive correlation between number of facilities consulted and total prescribed medications (Spearman's coefficient 0.39, P < 0.0001), remaining significant after adjustment for age.

General Medicine · Cureus · 1 Oct

Manganese Deposition Encephalopathy Associated With Prolonged Total Parenteral Nutrition: A Case Report

In patients on prolonged TPN with cholestasis, unexplained parkinsonism or MRI basal ganglia changes should prompt consideration of manganese toxicity from parenteral nutrition.

Neurology · Cureus · 1 Oct

When Diabetes Mimics Scleroderma: Cheiroarthropathy and Neuropathic Digital Erosions in Type 2 Diabetes

In long-standing diabetes with waxy, stiff hands, consider cheiroarthropathy before labelling scleroderma — it spares patients unnecessary rheumatology workup and immunosuppression.

Endocrinology · Cureus · 1 Oct

STAT+: HHS announces new efforts to speed up, expand clinical trials with AI

If US regulators standardise AI-assisted trial design and recruitment, Indian sites partnering on global studies may face new data and AI-governance expectations.

Medicine · STAT News — Health Tech · 1 Oct

Comparing a Dedicated Breast Spectral CT Protocol With Standard MonoE40 Reconstruction for Breast Cancer Characterization and Opportunistic Assessment

A dedicated spectral CT reconstruction may characterise breast tumours better than standard MonoE40, potentially improving staging in dense breasts without extra imaging.

Radiology · Cureus · 1 Oct

Anaplastic Large Cell Lymphoma of the Brain Mimicking an Extra-Axial Frontal Tumor: A Case Report

A dural-based frontal mass that looks like meningioma can be T-cell lymphoma; biopsy rather than assuming benign histology avoids delayed diagnosis.

Oncology · Cureus · 1 Oct

CMS finalizes model that aims to bring most-favored nation pricing to Part B

US Medicare Part B will pay no more than the lowest price other wealthy countries pay for physician-administered drugs, which may shift what your patients can access.

General Medicine · Fierce Healthcare · 30 Sept

The Verification Gap: Artificial Intelligence Adoption, Hallucination Awareness, and Verification Practices Among Medical Trainees and Professionals in Pakistan

Most trainees using AI tools cannot reliably spot fabricated references, so verify every AI-generated citation and dose before it reaches a patient or a paper.

General Medicine · Cureus · 30 Sept

Blueberry Muffin Sign: A Diagnostic Histochemical Clue in Mitochondrial Myopathy

In unexplained bilateral ptosis with ophthalmoplegia, requesting the blueberry muffin histochemical stain on muscle biopsy can confirm mitochondrial myopathy and end a decades-long diagnostic odyssey.

Neurology · Cureus · 30 Sept

Lithium Toxicity Following Initiation of Semaglutide in a Patient With Bipolar Disorder: A Case Report

If you co-prescribe semaglutide with lithium, check levels early: reduced intake and GI losses can push narrow-index lithium into toxicity.

Psychiatry · Cureus · 30 Sept

Digital Twins and Offline Reinforcement Learning for Mechanical Circulatory Support Decisions: What the Current Evidence Can and Cannot Support

Offline RL and digital twins could eventually guide MCS escalation and weaning decisions, but this review shows current evidence cannot yet support clinical use.

Cardiology · Cureus · 30 Sept

Employers increasingly tie digital health payments to outcomes, PHTI survey finds

If you prescribe or deploy digital health tools, reimbursement may soon hinge on documented outcomes rather than adoption, changing which vendors you can recommend.

Medicine · Fierce Healthcare · 30 Sept

Split-Thickness Skin Graft Versus Conservative Management for Deep Partial-Thickness Burns: A Systematic Review and Meta-Analysis

Weigh earlier graft closure against conservative healing in deep partial-thickness burns, where scarring and contracture risk, not speed alone, should drive the choice.

General Surgery · Cureus · 30 Sept

Use of Indocyanine Green Fluorescence in the Assessment of Bowel Perfusion in Emergency and Elective Colorectal Surgery: A Retrospective Cohort Study

One anastomotic leak (2.5%, 1 of 40) in the ICG group, in a transanal total mesorectal excision; ICG also changed intraoperative surgical strategy. Control-group leak data not reported.

General Surgery · Cureus · 30 Sept