Archive

Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunization.

Explains why whole-sporozoite malaria vaccines induce sterile protection, guiding which vaccine platforms may eventually reach travellers and endemic-region patients.

General Medicine · Nature microbiology · 30 Sept

Medical Applications of Graph Convolutional Networks Using Electronic Health Records: A Scoping Review

GCNs model relationships across EHR data to sharpen diagnosis and risk prediction, but this review finds most models remain unvalidated in real clinical workflows.

General Medicine · Cureus · 30 Sept

FDA Investigation Leads to Charges Against Two Indian Nationals Involved in Transnational Counterfeit Drug Distribution Scheme

Counterfeit medicines reaching Indian patients through online and grey channels are a real prescribing risk; verify sourcing and warn patients against unregulated purchases.

General Medicine · FDA — Press Announcements · 30 Sept

Physician Knowledge, Attitudes, and Practices Regarding Viral Exanthem Diagnosis and Mandatory Reporting Requirements in Major Metropolitan Regions of Florida, USA

Most clinicians miss mandatory reporting steps for measles and rubella; knowing your local reporting pathway matters more as outbreaks return.

General Medicine · Cureus · 29 Sept

Molecular and Conventional Tests in Onychomycosis: A Systematic Review of Paired Diagnostic Discordance and Clinical Interpretation

PCR and culture disagree often in onychomycosis, so a negative culture alone should not rule out fungal nail infection before starting or stopping treatment.

General Medicine · Cureus · 29 Sept

Loop-Mediated Isothermal Amplification as an Alternative to Conventional Smear Microscopy in Pulmonary Tuberculosis

Against the composite reference standard, TB-LAMP showed sensitivity 74.36% and specificity 91.80%, and identified cases missed by conventional techniques.

General Medicine · Cureus · 29 Sept

H1N1 dominates flu strains in India, accounts for 3 out of 4 cases: WHO

With H1N1 causing three of four flu cases, test and treat influenza early in febrile patients rather than presuming dengue or COVID.

General Medicine · ETHealthworld · 29 Sept

Combined Vitamin B12 and Folate Deficiency Presenting As Pseudo-Thrombotic Microangiopathy With a Disseminated Intravascular Coagulation (DIC)-Like Coagulation Profile: A Case Report

Haematologic and coagulation parameters improved within one week of starting vitamin B12 replacement; folic acid was started only after that first week

General Medicine · Cureus · 29 Sept

Diagnostic Accuracy of Rapid Diagnostic Tests Versus Enzyme-Linked Immunosorbent Assay (ELISA) Across Major Infectious Diseases: A Systematic Review and Meta-Analysis

RDTs trade some sensitivity for speed versus ELISA, so know the disease-specific gap before relying on a negative point-of-care result.

General Medicine · Cureus · 29 Sept

Dehydration in Tropical Fevers: Rethinking Fluid and Electrolyte Replacement

Dengue and scrub typhus cause isotonic and hypotonic losses that standard crystalloid protocols may worsen; reassess fluid choice and rate in these fevers.

General Medicine · Cureus · 29 Sept

Phylogeny-agnostic strain-level prediction of phage-host interactions from genomes using machine learning.

Could speed matching of phages to a patient's resistant strain, making phage therapy practical where antibiotic options are exhausted.

General Medicine · Nature microbiology · 29 Sept

Psoriatic Arthritis Without Cutaneous Manifestations: A Case of Diagnostic Delay, Pathologic Progression, and Psychological Burden

No skin lesions; family history of psoriasis in daughter and grandson prompted PsA diagnosis. DMARD plus escitalopram gave significant pain and mood improvement within one month.

General Medicine · Cureus · 29 Sept

Immunomodulatory Properties of Mesenchymal Stem Cells and Their Extracellular Vesicles: Potential Clinical Applications in Autoimmune Diseases

MSC-derived exosomes may offer cell-free immunomodulation for autoimmune disease, but this is a narrative review — no trial data yet to change your practice.

General Medicine · Cureus · 29 Sept

Beyond Hematuria: An Unexpected Diagnosis of Autosomal Dominant Polycystic Kidney Disease in a Young Adult Without a Family History

In a young adult with hematuria, don't stop at UTI or stones—absence of family history does not exclude ADPKD, and imaging plus renal function changes management.

General Medicine · Cureus · 28 Sept

Serum Vascular Endothelial Growth Factor and C-reactive Protein Serve As Biomarkers of Joint Health in Severe Haemophilia A: A Cross-Sectional Study From India

VEGF and CRP may flag haemophilic joint damage in Indian patients on on-demand factor, where imaging and prophylaxis access are limited.

General Medicine · Cureus · 28 Sept

OpenEvidence partners with Anthropic, Penn Medicine to expand physician access to AI across Africa and Asia

If you practise where specialist advice is scarce, this puts an AI second opinion on drug and diagnostic decisions at the point of care.

General Medicine · Fierce Healthcare · 28 Sept

Multidisciplinary Antimicrobial Stewardship Program in an Indian ICU: A Time-Series Analysis of Diagnostic Practices and Antibiotic Use

A multidisciplinary AMSP in an Indian ICU changed diagnostic and prescribing practice, giving you a locally tested model to cut unnecessary antibiotic use in your own unit.

General Medicine · Cureus · 28 Sept

Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials.

VRC01 prophylaxis blocks sensitive HIV strains but selects escape mutants in breakthrough infections, so antibody-only prevention may need combination bnAbs to avoid resistance.

General Medicine · Nature microbiology · 28 Sept

Efficacy and safety of garetosmab, an activin A-blocking antibody, in fibrodysplasia ossificans progressiva (OPTIMA): a randomised, double-blind, placebo-controlled, phase 3 trial.

First phase 3 win for an activin A blocker in FOP; if approved, it offers your ultrarare FOP patients the first therapy aimed at halting new heterotopic bone.

General Medicine · Lancet · 28 Sept

Artificial Intelligence in Delirium Care: Predicting, Detecting, and Preventing Delirium in Older Hospitalized Adults

Retrospective studies show promising discrimination and NLP finds delirium information missing from diagnostic codes, but performance often declines on external validation, calibration is inconsistently reported, and few systems have been tested prospectively.

General Medicine · Cureus · 27 Sept

Limited External Validation and Uncertain Clinical Utility of Prediction Models for Bacteriologically Negative Pulmonary Tuberculosis: A Systematic Review

Models that triage smear-negative TB have not been externally validated, so none can yet be trusted to decide who starts treatment.

General Medicine · Cureus · 27 Sept

Masked Triple-Negative Polycythemia Vera Initially Presenting as Iron Deficiency and Pernicious Anemia

Iron deficiency and B12 deficiency can normalise haemoglobin in PV, so check JAK2 and consider masked erythrocytosis before attributing anaemia solely to nutritional causes.

General Medicine · Cureus · 27 Sept

Posterior Neck Pain as the Initial Manifestation of Giant Cell Arteritis: A Diagnostic Challenge

Occipital headache or neck pain without temporal tenderness can still be GCA in older patients; consider ESR/CRP and steroids before vision loss occurs.

General Medicine · Cureus · 26 Sept

Effects of Sleep Deprivation on Oral Health: A Literature Review

No original data or effect sizes reported. Sleep loss is proposed to drive oral disease via immune dysregulation, salivary changes, glycemic dysregulation, bruxism and obstructive sleep apnea.

General Medicine · Cureus · 26 Sept

Mixed Autoimmune Hemolytic Anemia as the Initial Manifestation of Systemic Lupus Erythematosus: A Case Report

Hemoglobin 34 g/L, DAT positive for both IgG and IgM, ANA, anti-dsDNA and anti-Smith positive. Remission achieved with prednisolone, mycophenolate mofetil, belimumab and hydroxychloroquine.

General Medicine · Cureus · 26 Sept

Spatiotemporal Analysis of Dengue Incidence and Associated Factors: An Ecological Study Across Municipalities in Bahia, Brazil (2019-2024)

Incidence was lowest in 2021 (166.6 per 100,000) and highest in 2024 (1,558.7 per 100,000). Income was positively associated with incidence; sewerage coverage and Black/mixed-race proportion were negatively associated in 2024.

General Medicine · Cureus · 26 Sept

Circadian-Based Optimization of Pharmacotherapy in Chronic Diseases: Integrating Pharmacokinetics, Pharmacodynamics, and Disease Rhythm

Timing some chronic-disease drugs to the body clock can change efficacy and toxicity, so review whether your patients' dosing schedules match their disease rhythm.

General Medicine · Cureus · 25 Sept

Persistent Type B Hyperlactataemia as a Diagnostic Clue to Occult Diffuse Large B-cell Lymphoma-Associated Haemophagocytic Lymphohistiocytosis

Lactate stayed elevated despite fluids and no acidosis; HScore 186 with hypertriglyceridaemia and raised LDH. Bone marrow biopsy confirmed DLBCL. R-mini-CHOP normalised lactate, counts and liver function, with complete metabolic response on PET-CT after two cycles.

General Medicine · Cureus · 25 Sept

High-Dose Tigecycline for Multidrug-Resistant Serratia Infections in Critically Ill Adults: A Systematic Review of Direct and Indirect Clinical Evidence

Evidence for high-dose tigecycline in resistant Serratia is indirect, so treat it as a last-line option and weigh the mortality signal before escalating the dose.

General Medicine · Cureus · 25 Sept

Anticoagulation Dilemma in a Patient With Pulmonary Embolism and Massive Haemoptysis

Haemoptysis worsened after starting apixaban and persisted despite dose adjustments; she was stabilised and discharged on warfarin. No laboratory or outcome figures reported.

General Medicine · Cureus · 25 Sept

Immunogenicity and safety of high-dose versus double-dose quadrivalent inactivated influenza vaccine in adult kidney transplant recipients: a randomized controlled trial (2023).

Seroconversion to at least one strain was 95.2% with high-dose versus 69% with double-dose (P = 0.002); absolute difference 0.26 (95% CI, 0.12-0.40). Injection site pain and myalgia were less common with high-dose.

General Medicine · Lancet regional health. Southeast Asia · 25 Sept

A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA

Markedly raised WT1 mRNA without blasts may flag occult myeloid malignancy in hypereosinophilia, so consider marrow WT1 testing before labelling it idiopathic.

General Medicine · Cureus · 25 Sept

Overlapping Post-COVID Conditions: A Case of Myalgic Encephalomyelitis and Postural Orthostatic Tachycardia Syndrome Triggered by Sequential Epstein-Barr Virus (EBV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections

Diagnosed with ME/CFS in early 2023 and POTS later that year; low-dose naltrexone, duloxetine and PEA with pacing gave only partial, fluctuating response.

General Medicine · Cureus · 24 Sept

Campylobacter rectus Thoracic Empyema in a Severely Malnourished Host With Preserved Conventional Immune Markers: A Case Report and Literature Review

Consider oral periodontopathogens like C. rectus in empyema when routine cultures are sterile, even if standard immune markers look normal.

General Medicine · Cureus · 24 Sept

How to combat the insurer payment delays that are destabilizing independent medicine

Persistent No Surprises Act payment delays strain independent practice cash flow, so know the IDR timelines and documentation you can use to chase unpaid claims.

General Medicine · Fierce Healthcare · 24 Sept

FSSAI proposes single-phase food warning labels, gives industry one-year transition time

Red hexagon labels on high sugar, fat and salt foods give you a concrete counselling tool for diet-related diabetes, obesity and hypertension in Indian patients.

General Medicine · ETHealthworld · 24 Sept

Clinical Uses of Common Genetic Variants Associated with Common Diseases.

Thousands of small-effect variants underpin polygenic risk; scores predict risk, yet have had little effect in the clinic. No effect sizes reported.

General Medicine · NEJM · 24 Sept

Pseudomonas aeruginosa induces the generation of pathogenic IFNγ(+)Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis.

Two pathogenic Th17 subsets, Th1/17+ and pTh17, were selectively enriched in CF lungs colonised by P. aeruginosa, derived from cTh17 precursors, and disrupted epithelial integrity.

General Medicine · Nature microbiology · 24 Sept

Standardising Pleural Management in Suspected Malignant Pleural Effusion Using a Structured Pre-Test Probability and RED Score-Guided Proforma: A Single-Centre Before-and-After Quality Improvement Project

Unplanned admission or early review fell from 16/48 (33.3%) to 2/26 (7.7%); risk difference −25.6% (95% CI −42.5 to −8.8), P=0.021. Procedures beyond two: 33.3% to 22.7%, not significant.

General Medicine · Cureus · 24 Sept

Prevalence and Trends of Post–COVID-19 Sequelae Among U.S. Adults With Prior COVID-19 Infection, 2022–2024

PASC prevalence declined from 19.7% in 2022 to 15.1% in 2023 and 13.7% in 2024 (P<0.001 for 2022 vs subsequent years); 6,822 of 42,872 reported PASC. Higher in women and adults aged 35-64.

General Medicine · Cureus · 24 Sept