Archive

First Once-Weekly Oral HIV Treatment Demonstrates Safety and Efficacy

Weekly oral regimen could replace daily pills, easing adherence burden for stable HIV patients on suppressive therapy.

General Medicine · JAMA · 1 Sept

Safe Sleep Video Intervention via Text Messaging to Low-Income Families

Text-delivered safe sleep videos may reduce unsafe infant sleep practices in low-income families—consider integrating into prenatal and postnatal outreach.

Paediatrics · JAMA · 1 Sept

Problematic Social Media Use Linked to Increased ADHD Symptoms in Adolescents

Screen for problematic social media use in teens with ADHD symptoms; reducing use may help manage attention difficulties.

Psychiatry · JAMA · 1 Sept

Dapagliflozin and Risk of Perioperative Acute Kidney Injury in Cardiac Surgery

Perioperative AKI after cardiac surgery is common; this trial tests whether continuing SGLT2 inhibitors changes that risk, informing your pre-op medication decisions.

Cardiology · JAMA · 1 Sept

Physician Advice on E-Cigarettes for Smoking Cessation

Helps you navigate the e-cigarette counseling dilemma with evidence-based guidance for patients who smoke.

General Medicine · JAMA · 1 Sept

AI-Powered Scribes and Clinician Time Expenditure and Visit Quantity

Real-world data show AI scribes may not cut total EHR time or boost visits—so don't expect burnout relief from this tool alone.

General Medicine · JAMA · 1 Sept

Mechanical Thrombectomy in Ischemic Stroke With Medium or Distal Arterial Occlusion

For stroke patients with medium or distal occlusions, this trial clarifies whether adding thrombectomy to medical therapy improves outcomes—directly guiding your reperfusion decisions.

Neurology · JAMA · 1 Sept

SGLT2 Inhibitors for Prevention of AKI

Starting dapagliflozin the day before elective cardiac surgery may cut postoperative AKI—consider timing and renal risk in your surgical patients.

Cardiology · JAMA · 1 Sept

Lyme Disease Is Outpacing Medical Advances

Lyme disease is spreading; new diagnostics and vaccines are emerging, but practical hurdles delay their clinical use.

General Medicine · JAMA · 1 Sept

A Framework for Clinicians Navigating Wearable Data in the AI Era

Helps you interpret ambiguous wearable data without over-testing or missing real issues, offering a structured approach for patient conversations.

General Medicine · JAMA · 1 Sept

How Common Is Alpha-Gal Syndrome?

Know that 6-31% of adults in tick-endemic US regions carry alpha-gal IgE, but clinical allergy is rarer—test only symptomatic patients.

General Medicine · JAMA · 1 Sept

Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion Research Summary

For stroke patients with medium or distal clots, this trial tests whether adding thrombectomy to standard care improves functional recovery—directly informing your reperfusion decisions.

Neurology · JAMA · 1 Sept

AI-Powered Scribes and Clinician Time Expenditure and Visit Quantity

Ambient AI scribes cut total EHR time modestly but not after-hours work; savings may shift to other tasks, so don't expect burnout relief.

General Medicine · JAMA · 1 Sept

Surgical and Endoscopic Therapies for GERD

Helps you choose among newer endoscopic options for GERD patients who fail or decline PPIs, balancing efficacy and invasiveness.

General Surgery · JAMA · 1 Sept

Addition of High-Dose Vitamin D 3 to Standard Treatment in Patients With Metastatic Colorectal Cancer Research Summary

High-dose vitamin D3 may extend progression-free survival in metastatic colorectal cancer; consider adding to standard chemotherapy.

Oncology · JAMA · 1 Sept

CDC Reports Increase in Candida auris Infections

Rising drug-resistant Candida auris cases mean you must suspect it in hospitalized patients with prior antifungals and send cultures promptly.

General Medicine · JAMA · 1 Sept

One-Year Outcomes After Endovascular Treatment for Large Acute Ischemic Stroke

Confirms thrombectomy benefit persists at 1 year for large-core strokes, supporting its use in patients you might otherwise manage medically.

Neurology · JAMA · 1 Sept

Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery Research Summary

If dapagliflozin cuts post-op AKI, you can start it pre-surgery to protect kidneys in high-risk cardiac patients.

Cardiology · JAMA · 1 Sept

Trouble Lies Ahead for Global Immunization Coverage

Expect more vaccine-preventable disease outbreaks in your practice; check and catch up children behind on routine immunizations.

Paediatrics · JAMA · 1 Sept

Compounded GLP-1 Drugs Remain Prevalent After Drug Shortage

Patients may still use unregulated compounded GLP-1s; verify sources and counsel on safety now that branded options are available.

Endocrinology · JAMA · 1 Sept

Medtronic recalls reflux monitoring device as 184 serious injuries linked to capsule

If you place pH capsules for reflux workup, check your stock—recalled delivery devices may fail in situ, risking injury.

Gastroenterology · Fierce Biotech · 1 Sept

Boston Scientific halts sales of angiographic catheters amid 2 serious injuries

Check your stock of Imager II catheters; tip defect may cause serious injury—stop use and follow recall instructions.

Cardiology · Fierce Biotech · 1 Sept

Periconception Parental Red Blood Cell Folate, Vitamin B(12), and Birth Defects in Offspring : A Prospective Cohort Study.

Higher preconception parental vitamin B12 predicted lower birth-defect prevalence: maternal <148 to ≥590 pmol/L decreased from 49.6 to 16.2 per 1000; paternal 55.5 to 24.0. Postconception maternal RBC folate 906-1131 vs <453 nmol/L: 16.5 vs 25.7 per 1000.

Obstetrics & Gynaecology · Annals · 1 Sept

Impact of violence against medical professionals: An online survey of medical practitioners in India.

80.2% reported facing or witnessing workplace violence; verbal abuse most common, followed by physical and sexual violence.

General Medicine · National medical journal of India · 1 Sept

Effect of zero-separation in mother-newborn care unit on preterm infant's stress and growth.

MNCU infants had lower stress and better growth: cortisol fell by -0.2±0.4µg/dL versus +0.43±0.3 µg/dL in NICU (P<0.001); PIPP 6.7±2.5 vs. 12.68 ± 2.03 (P<0.001); daily weight gain 19.7±11.08 vs. 8.3±6.6 g/day (P<0.001).

Medicine · Indian journal of medical research · 1 Sept

Ethics and Professionalism in Artificial Intelligence and Medical Practice: A Position Paper From the American College of Physicians.

No numerical data; proposes three guideposts: relationality, self-governance, competence, rooted in patient-physician relationship.

General Medicine · Annals · 1 Sept

Predicting clinical outcomes in polytrauma patients using components of the Berlin definition of polytrauma.

ISS+PRFs significantly influenced mortality and cost of care >₹0.63 million (6.3 lakhs), but not ICU/hospital stay in survivors.

Medicine · National medical journal of India · 1 Sept

Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction.

Low ISM2 was the strongest protein signal for preeclampsia or FGR; knockdown inhibited EVT invasion, ISM2 expression promoted migration.

Obstetrics & Gynaecology · Nature Medicine · 1 Sept

Thiamine deficiency in oncology: Clinical insights from two cases of Wernicke's encephalopathy.

Both patients showed positive clinical response after immediate intravenous thiamine; early recognition and treatment made neurological deficits potentially reversible.

Oncology · National medical journal of India · 1 Sept

Acceptability, benefits, and challenges of teleconsultation: A qualitative study among doctors in Manipur.

Thematic saturation was achieved after 11 interviews. Doctors perceived teleconsultation as acceptable and beneficial: improved access, early referral, chronic-disease follow-up, EMRs; challenges were connectivity, no physical exam, workload, unclear guidelines, medicine and diagnostic shortages.

General Medicine · Indian journal of medical research · 1 Sept

Prevalence and diagnostic variability of sarcopenia in India: A systematic review and meta-analysis.

Probable sarcopenia pooled prevalence 36.3% (95% CI: 26-48%, 18 studies); confirmed 35.4% (95% CI: 28.8-42.5%, 38 studies); severe 9.9% (95% CI: 5.6-16.7%, 11 studies).

Medicine · Indian journal of medical research · 1 Sept

Enhancing rural healthcare delivery in India: eSanjeevani and the community health officer perspective.

Response rate was 88.3% (n=106). Daily use by 53.77%; usefulness: skin 50.9%, paediatric 45.3%, maternal 42.5%, diabetes 39.6%, hypertension 38.7%; limitations: specialist availability 58.49%, connectivity 22.64%, extended waiting times 15.1%.

Medicine · National medical journal of India · 1 Sept

Atezolizumab in early triple-negative breast cancer: the randomized phase 3 NSABP B-59/GeparDouze trial.

Event-free survival not significantly improved (HR 0.80, 95% CI 0.062-1.03; P=0.083; 4-year EFS difference 3.3%). Overall survival HR 0.86 (95% CI 0.62-1.19).

Oncology · Nature Medicine · 1 Sept

Molecular subtyping and POLE mutation spectrum in endometrial carcinoma.

Molecular classification found POLE ultra-mutated 3.8% (n=2), MMR-deficient 18.9% (n=10), p53-abnormal 17.0% (n=9), and NSMP 37.7% (n=20). POLE sequencing found 11 exonuclease domain variants; V411L was 3.8% (n=2).

Medicine · Indian journal of medical research · 1 Sept

Carbapenem-resistant and other multidrug-resistant organisms in a South Indian tertiary care centre: A laboratory-based study.

Of 8,704 specimens, 3,450 (39.6%) culture-positive; 750 (34.2%) multidrug-resistant. CRE 65.3%, mortality 191/750 (25.5%).

General Medicine · Indian journal of medical research · 1 Sept

Antifungal therapy improves microbiome dynamics in inflammatory bowel disease.

Fluconazole reduced intestinal Candida burden and reshaped fungal composition, increased bacterial diversity, and improved disease activity indices with decreased risk of progression over 8 weeks; nystatin had no effect.

Gastroenterology · Nature Medicine · 1 Sept

Decreasing contamination rates in blood cultures: A plan-do-study-act approach.

Contamination decreased from 10.7% to 3.4% (p<0.0001) after implementing training and supervised collection.

Medicine · National medical journal of India · 1 Sept

Occupational wood dust exposure and lung function impairment: A systematic review and meta-analysis.

Workers exposed to wood dust had lower FEV1 percentage predicted (pooled MD -8.57; 95% CI -12.07 to -5.08; 16 studies), FVC percentage predicted (pooled MD-7.43; 95% CI -11.35 to -3.51; 14 studies), and PEFR percentage predicted (pooled MD -13.43; 95% CI -25.14 to -1.72; 9 studies).

Medicine · National medical journal of India · 1 Sept

Systematic review of medical audits of hysterectomy practices in India.

Hysterectomies were mostly in premenopausal women; one-fourth in women under 40. Leading indications: abnormal uterine bleeding and fibroids. Oophorectomy often done without documented ovarian pathology.

Medicine · Indian journal of medical research · 1 Sept

Empowering accredited social health activist (ASHA) workers to support community mental health in Karnataka State of India: A systematic review.

Improved provider competencies and service delivery outcomes; digital and hybrid models showed more sustained gains than standalone in-person training.

Psychiatry · Indian journal of medical research · 1 Sept