Archive

Congenital Bile Acid Synthesis Defect Type 2 Mimicking Biliary Atresia: A Case Report of Delta-4-3-Oxosteroid 5-Beta-Reductase Deficiency in a Two-Month-Old Infant

Urine LC-MS/MS showed trace primary bile acids with Δ4-3-oxo intermediates; NGS confirmed CBASD type 2. Liver biopsy showed giant cell hepatitis without ductal proliferation, excluding BA.

Paediatrics · Cureus · 15 Sept

Molecular Etiology and Mortality Risk Stratification of Non-SARS-CoV-2 Severe Acute Respiratory Infection in a Predominantly Pediatric Cohort: A Retrospective Study From a Tertiary Care Hospital in North India

In North Indian children with non-COVID SARI, the ViVI severity score may help you flag those at higher mortality risk early and target escalation.

Paediatrics · Cureus · 14 Sept

Late-Onset Neonatal Cyanosis Secondary to Methemoglobinemia in a Preterm, Small-for-Gestational-Age Infant: A Case Report

In a preterm neonate with unexplained desaturations unresponsive to oxygen, check methemoglobin — methylene blue and vitamin C correct it, and pulse oximetry alone will mislead you.

Paediatrics · Cureus · 14 Sept

Transient Post-infectious Multisystem Inflammatory Overlap Presentation in a Pediatric Patient With Neurological, Hepatic, Gastrointestinal, and Autoimmune Manifestations: A Rare Case From Azerbaijan

Transient autoantibody positivity and incidental neuroinflammatory imaging changes, hepatic steatosis and gastrointestinal inflammation appeared disproportionate to clinical status and resolved without immunosuppression or invasive intervention

Paediatrics · Cureus · 13 Sept

When Fever Hides Fire: A Systematic Review of Clinical and Digital Approaches to Early Recognition of Pediatric Sepsis

Approaches performed well ruling out sepsis in low-risk children, but case detection and alert burden varied by thresholds, settings, and sepsis definitions; no approach was consistently superior

Paediatrics · Cureus · 13 Sept

Racial and Ethnic Disparities in Receipt of Behavioral Treatment Among Children With Autism Spectrum Disorder in the United States

564 of 790 (71.4%) received behavioural treatment. Non-Hispanic Black children were less likely than White children to receive it (adjusted OR 0.47, 95% CI 0.28-0.79). Asian, Hispanic and multiracial differences were not significant.

Paediatrics · Cureus · 12 Sept

Hyperglycemic Hyperosmolar State As the Initial Presentation of Type 1 Diabetes Mellitus in an Adolescent: A Case Report

Glucose exceeded 1,000 mg/dL with hyperosmolality, dehydration and only mild acidosis; treatment caused marked glucose swings needing repeated insulin and dextrose titration.

Paediatrics · Cureus · 11 Sept

Pediatric Headache: A Practical Approach to Clinical Diagnosis and Management

No numerical results reported. Diagnosis rests on structured history, disability assessment and examination; red flags prompt risk stratification rather than reflexive neuroimaging

Paediatrics · Cureus · 11 Sept

Immunogenicity of fractional one-fifth and one-half doses of 17DD yellow fever vaccine compared with full dose in children aged 9-23 months in Uganda: a phase 4, single-blind, randomised clinical trial.

Both fractional doses met non-inferiority (5 percentage-point margin) for seroconversion at 4 weeks; one-half versus full dose difference was -0.17 (95% CI -0.52 to 0.17), with no difference between one-fifth and full doses.

Paediatrics · Lancet · 11 Sept

Profile of Invasive Fungal Infections in a Paediatric Haemato-Oncology Unit: A Five-Year Retrospective Cohort Study From a Tertiary Care Centre in South India

33 IFI episodes in 23 patients; Candida and Aspergillus each 43.5%. All 20 Candida episodes were fungemia, 60.0% Candida tropicalis, 100% fluconazole-susceptible. Mortality 26.1% overall: 0 Candida, 30% aspergillosis, 100% mucormycosis.

Paediatrics · Cureus · 10 Sept

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants: The AIROPLANE Cluster Randomized Crossover Trial.

Ongoing respiratory support when leaving the delivery room: 700 of 964 (72.6%) with Fio2 0.30 vs 626 of 854 (73.3%) with Fio2 0.21; risk difference -0.83 (95% CI, -4.33 to 2.67).

Paediatrics · JAMA · 9 Sept

PIL challenges Centre’s HPV vaccination drive, seeks Supreme Court intervention over consent, safety and accountability

School-based HPV vaccination may pause; verify consent protocols and legal status before counselling parents or administering doses.

Paediatrics · ETHealthworld · 7 Sept

FDA Takes Steps to Maintain Newborn Access to Life-Saving Starter Nutrition Products

Ensures neonatal intensive care units can keep stocking starter PN for premature infants during potential shortages, preventing treatment delays.

Paediatrics · FDA — Press Announcements · 5 Sept

FSSAI plans curbs on high-fat food sales within 50 metres of schools, CEO Rajit Punhani says

This may reduce childhood obesity and metabolic risk; paediatricians should counsel families on healthier snack choices near schools.

Paediatrics · ETHealthworld · 4 Sept

Safe Sleep Video Intervention via Text Messaging to Low-Income Families

Text-delivered safe sleep videos may reduce unsafe infant sleep practices in low-income families—consider integrating into prenatal and postnatal outreach.

Paediatrics · JAMA · 1 Sept

Trouble Lies Ahead for Global Immunization Coverage

Expect more vaccine-preventable disease outbreaks in your practice; check and catch up children behind on routine immunizations.

Paediatrics · JAMA · 1 Sept

FDA Approves First Gene Therapy for Young Children with Sickle Cell Disease

Now offers a one-time cure option for children as young as 2 with recurrent crises, potentially ending years of transfusions and pain.

Paediatrics · FDA — Press Announcements · 2 Jul