Archive

Not All Brain Bleeds Are Equal: An Etiology-First Framework for Stroke Prevention After Intracerebral Hemorrhage

Before restarting a DOAC after ICH, weigh the bleed's cause: lobar amyloid bleeds recur more than deep hypertensive ones, so the anticoagulation decision should differ.

Neurology · Cureus · 24 Sept

Acadia misses mark in Alzheimer’s but concludes phase 3 ‘absolutely worth’ pursuing

A negative phase 2 in Alzheimer's still advancing to phase 3 signals the endpoint may be wrong, not the drug — wait for phase 3 before discussing this with patients.

Neurology · Fierce Biotech · 24 Sept

Recurrent Ischemic Stroke Despite Dabigatran Therapy: Unexpectedly Low Anti-IIa Activity Revealing Pharmacokinetic Treatment Failure

If a patient strokes on dabigatran, measure anti-IIa activity rather than assuming non-adherence — confirmed low levels may mean switching anticoagulant.

Neurology · Cureus · 23 Sept

Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial.

If bridging tenecteplase improves outcomes in late-presenting basilar occlusion, it changes your thrombolysis decision for posterior-circulation strokes beyond the 4.5-hour window.

Neurology · JAMA · 23 Sept

AI-based characterization of Alzheimer's disease phenotypes from population-scale single-cell data.

Explains why Alzheimer's patients differ in psychosis and cognitive decline, pointing toward phenotype-specific targets rather than one-size-fits-all treatment.

Neurology · Nature Medicine · 23 Sept

Impact of Premorbid Function and Comorbidities in Geriatric Traumatic Brain Injury Patients: A Systematic Review

In TBI patients over 60, baseline frailty and comorbidity predict mortality and recovery better than age alone, so weigh premorbid function when discussing prognosis and goals of care.

Neurology · Cureus · 23 Sept

Radiological Correlates of Headache and Papilledema in Patients Undergoing Cranial MRI: Clinical Relevance of the Evans Index and Fazekas Score

Incidental ventriculomegaly or white-matter changes on MRI may not explain your patient's headache or papilledema, so don't anchor the workup on these scores alone.

Neurology · Cureus · 22 Sept

Otsuka heads to FDA as Ionis-partnered ALS drug hits primary phase 3 endpoint

A positive phase 3 in ALS gives your patients a new disease-modifying option and a likely expedited FDA pathway to access it.

Neurology · Fierce Biotech · 22 Sept

Traumatic Macroglossia Associated With Clustered Epileptic Seizures in a Patient With Down Syndrome

In drug-resistant epilepsy with seizure clusters, tongue biting can cause macroglossia and acute airway obstruction; watch for tongue swelling after clustered tonic seizures.

Neurology · Cureus · 22 Sept

Anaconda Biomed snares $56M in funding for endovascular tech

Funds a pivotal trial of a next-gen aspiration catheter for large-vessel stroke thrombectomy, which may improve clot retrieval when current devices fail.

Neurology · Fierce Biotech · 22 Sept

Alzheimer’s cases in India could be up to 5 times higher than reported number: Experts

Dementia is likely far more common than clinic figures suggest, so screen cognitively in older patients rather than waiting for memory complaints.

Neurology · ETHealthworld · 21 Sept

Beyond the Hospital: Spatial Inequality and Structural Divergence in Stroke Mortality Across the United States (2020-2024)

Largest relative increases in medium (+8.4%) and large fringe metros (+7.3%); home deaths surged in 2021 (n=41,423); out-of-hospital Gini=0.5321 versus in-hospital Gini=0.5045.

Neurology · Cureus · 21 Sept

Cell-Type-Specific Transcriptomic Alterations in the Epileptic Prefrontal Cortex and Complementary Neuroimaging Findings in an Independent Cohort

Maps which prefrontal cell types are transcriptionally altered in epilepsy and links them to imaging changes, pointing toward cell-specific targets rather than seizure-focus-only models.

Neurology · Cureus · 21 Sept

Imaging Correlation of Color Doppler Ultrasound, CT Angiography, and MR Angiography Findings in Extracranial Carotid and Vertebral Artery Disease Among Ischemic Stroke Patients: A Prospective Observational Study

Doppler agrees well enough with CTA/MRA for first-line carotid and vertebral stenosis workup, so you can triage stroke patients without immediate advanced angiography.

Neurology · Cureus · 21 Sept

Basilar Artery Occlusion Associated With Paradoxical Embolism After Traumatic Spinal Cord Injury: A Case Report

CT angiography showed partial distal basilar occlusion; mechanical thrombectomy by direct aspiration achieved complete reperfusion (TICI 3). Echocardiography showed right-to-left shunting with more than 30 microbubbles from the second cardiac cycle.

Neurology · Cureus · 21 Sept

Endovascular Thrombectomy in Patients With Cancer and Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Recanalization 77.1%, sICH 4.5%, mRS ≤2 in 26.8%, 90-day death 39.4%. Versus controls: mRS ≤2 RD -0.170 (95% CI -0.223 to -0.116); mortality RD 0.234 (95% CI 0.168 to 0.300).

Neurology · Cureus · 21 Sept

Antiphospholipid Syndrome as an Under-Recognized Cause of Ischemic Stroke in Older Adults: A Retrospective Case Series

Consider testing antiphospholipid antibodies in stroke patients over 65, not just the young—seven cases here suggest it is missed in older adults.

Neurology · Cureus · 21 Sept

A Small Dose With Large Movements: Suspected Gabapentin-Associated Mixed Hyperkinetic Movement Disorder in End-Stage Renal Disease: A Case Report

Involuntary jerking and truncal sway appeared after roughly one month of gabapentin; movements and altered affect resolved within approximately 48 hours of discontinuation

Neurology · Cureus · 20 Sept

Ocrelizumab Discontinuation After Recurrent Serious Infections in Clinically Stable Primary Progressive Multiple Sclerosis: A Case Report

In stable PPMS patients on long-term ocrelizumab, recurrent serious infections may justify stopping therapy even without disease activity — weigh infection risk against relapse risk as patients age.

Neurology · Cureus · 20 Sept

Lower Motor Neuron Disease Misclassified As Inflammatory Myopathy in a Young Woman With Myositis-Specific Antibodies

Despite creatine kinase normalisation on immunosuppression, weakness and wasting progressed; re-evaluation showed widespread fasciculations, neurogenic atrophy, and a lower-motor-neuron-predominant ALS phenotype.

Neurology · Cureus · 20 Sept

When Weakness Persists Beyond Its Apparent Cause: A Case Report of Myasthenia Gravis

In a patient with diarrhea and hypokalemia, weakness that persists after potassium correction should prompt consideration of myasthenia gravis rather than being attributed to the electrolyte deficit alone.

Neurology · Cureus · 20 Sept

Efficacy of Medical Treatment Options for Reducing the Risk of Bleeding in Patients With Sporadic and Familial Cerebral Cavernous Malformations: A Systematic Review and Network Meta-Analysis

Statin vs no treatment: OR 0.32 (95% CI 0.14-0.73) for follow-up bleeding. Triple therapy vs none: OR 0.24 (0.06-0.95). Beta-blocker monotherapy vs antithrombotic: OR 2.41 (1.13-5.10).

Neurology · Cureus · 18 Sept

Sex Differences in Early Functional Outcomes After Acute Stroke: A Retrospective Cohort Study at a United Kingdom Tertiary Stroke Centre

Unadjusted, women had worse discharge mRS (common OR 1.34, 95% CI 1.10–1.64). After adjusting for age and pre-stroke mRS the association fell to 0.95 (95% CI 0.77–1.16) and fully adjusted 0.94 (0.76–1.16).

Neurology · Cureus · 17 Sept

Suspected Bulbar-Predominant Myasthenia Gravis Exacerbation in an Older Adult With Respiratory Deterioration and Silent Aspiration: A Case Report

Videofluoroscopy showed significant silent aspiration of thin and mildly thickened liquids; serial blood gases showed persistent hypercapnia with preserved pH and markedly elevated bicarbonate. Respiratory status stabilized on IVIG and steroids, but bulbar dysfunction and dysphagia persisted.

Neurology · Cureus · 17 Sept

Not All Transverse Sinus Stenoses Behave the Same: Distinct Flow Phenotypes on Phase-Contrast MRI

Mean peak velocity was 16.97 cm/s proximal, 12.84 cm/s intra-stenotic and 14.82 cm/s distal. Ten segments (55.6%) were low-flow, seven (38.9%) jet, one (5.6%) intermediate.

Neurology · Cureus · 17 Sept

Closed-Loop Neuroprosthetics: Advancing Long-Term Solutions for Brain-Level Function Restoration

No usable figures reported. Author attributes failure to reach clinical practice to material fatigue, electrode degradation, inflammation and electrical drift degrading sensing and stimulation over time.

Neurology · Cureus · 16 Sept

Novartis ends ALS program after phase 2 flop, adding to R&D woes

Another negative ALS trial leaves your patients with no new disease-modifying option; enrolment in remaining ALS studies is now the only route to change that.

Neurology · Fierce Biotech · 16 Sept

The Mask of Delirium: Uncovering a Presumed Cardioembolic Stroke Through Comprehensive Clinical Evaluation

MRI confirmed acute left temporal restricted diffusion; troponin I was 1026.3 and 1060.5 ng/L, NT-proBNP 7451 pg/mL, and ejection fraction 15% to 20%.

Neurology · Cureus · 16 Sept

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse.

Supports EBV-directed monitoring or antiviral strategies as a way to anticipate and possibly prevent MS relapses in your RRMS patients.

Neurology · Nature Medicine · 16 Sept

Revascularization in Asymptomatic Carotid Artery Stenosis With Hemodynamic Impairment and Cognitive Outcomes: The CREST-H Substudy of the CREST-2 Randomized Clinical Trial.

No treatment difference in cognitive z score over 1 year: adjusted difference -0.15 SD (95% CI, -0.54 to 0.24). Treatment × hemodynamic interaction not significant (β=0.018; 95% CI, -0.025 to 0.061; P=.40)

Neurology · JAMA · 16 Sept

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.

No between-group difference in adjusted composite z score at 4 years: CAS trial 0.03 (95% CI, -0.09 to 0.15); CEA trial 0.02 (95% CI, -0.09 to 0.14). No individual test differed.

Neurology · JAMA · 16 Sept

External Lumbar Drainage for Refractory Intracranial Hypertension in Acute Brain Injury: A Narrative Review and Case Series

In refractory ICP above 22 mmHg despite maximal therapy, ELD may lower pressure without decompressive craniectomy, but case selection and herniation risk remain unresolved.

Neurology · Cureus · 16 Sept

Memantine-Induced Sialorrhea: A Rare Adverse Reaction and Review of Pathophysiological Mechanisms

If a dementia patient on memantine develops unexplained drooling, consider the drug as the cause rather than assuming progression or a new neurological deficit.

Neurology · Cureus · 15 Sept

Effectiveness of Virtual Reality-Based Rehabilitation on Balance, Gait, and Functional Independence in Patients With Parkinson’s Disease: Implications for Healthy Longevity

Berg Balance Scale improved +8.97 versus +4.52 points, TUG −3.51 versus −1.79 seconds, gait speed +0.234 versus +0.111 m/s; 108 of 125 (86.4%) versus 34 of 125 (27.2%) reached lower fall-risk category.

Neurology · Cureus · 15 Sept

Axoltis misses the mark in phase 2 ALS study, but still strives to move towards the clinic

A negative phase 2 in ALS means no new option is imminent; continue standard multidisciplinary care and consider enrolling patients in other ongoing ALS trials.

Neurology · Fierce Biotech · 14 Sept

Persistent HyperCKemia Beyond Post-Viral Myositis: A Case of Anti-HMGCR Immune-Mediated Necrotizing Myopathy

CK fell to 376 U/L (N 30-200 U/L) four months after admission on high-dose corticosteroids then methotrexate, with complete recovery of muscle strength and swallowing.

Neurology · Cureus · 14 Sept

Idiopathic Normal Pressure Hydrocephalus: A Review.

Gait disturbance occurs in 85%-95%, urinary dysfunction in 75%-90%, cognitive impairment in 60%-80%. After shunting, gait velocity improves in 75%-80%, cognition and urinary symptoms in 50%-70%.

Neurology · JAMA · 14 Sept

Beat-to-Beat Nystagmus Differentiation Between Benign Paroxysmal Positional Vertigo (BPPV) and Vestibular Migraine (VM): A Cross-Sectional Videonystagmographic Study From Northern India

Peak nystagmus amplitude and slow-phase velocity were higher in BPPV (mean peak amplitude 11.55° vs 5.64°, p=0.02; mean peak SPV 21.16°/s vs 13.10°/s, p=0.005).

Neurology · Cureus · 13 Sept

Systematic Review and Meta-Analysis on Central and/or Peripheral Nervous System Demyelination in Patients Treated With Tumor Necrosis Factor Alpha (TNF-α) Inhibitors

Pooled random-effects estimates: RR 1.46 (95% CI 1.09-1.95) for CNS demyelination and RR 2.00 (95% CI 1.19-3.38) for PNS demyelination.

Neurology · Cureus · 11 Sept

Cardiac Metastasis From Lung Cancer: A Hidden Cardioembolic Source of Acute Ischemic Stroke

Brain MRI showed multiple acute ischemic infarcts in the left middle cerebral artery territory; cardiac imaging found a left ventricular mass suggestive of metastasis. She died one year later.

Neurology · Cureus · 11 Sept